gsk-1363089 and Wallerian-Degeneration

Axon degeneration is an early event and pathological in neurodegenerative conditions and nerve injuries. To discover agents that suppress neuronal death and axonal degeneration, we performed drug screens on primary rodent neurons and identified the pan-kinase inhibitor foretinib, which potently rescued sympathetic, sensory, and motor

Topics: Adrenergic Fibers; Anilides; Animals; Apoptosis; Apoptosis Regulatory Proteins; Axons; Cells, Cultured; Crush Injuries; Cytoprotection; Disease Models, Animal; Dose-Response Relationship, Drug; Genotype; Mice, Inbred C57BL; Mice, Transgenic; Mitochondria; Motor Neurons; Mutation; Neurons; Neuroprotective Agents; Phenotype; Phosphorylation; Protein Kinase Inhibitors; Quinolines; Rats, Sprague-Dawley; Receptor, trkA; Sciatic Nerve; Sciatic Neuropathy; Sensory Receptor Cells; Signal Transduction; Superoxide Dismutase-1; Time Factors; Transcription, Genetic; Wallerian Degeneration