gsk-1034702 and Cognition-Disorders

gsk-1034702 has been researched along with Cognition-Disorders* in 2 studies

Trials

1 trial(s) available for gsk-1034702 and Cognition-Disorders

ArticleYear
The potent M1 receptor allosteric agonist GSK1034702 improves episodic memory in humans in the nicotine abstinence model of cognitive dysfunction.
    The international journal of neuropsychopharmacology, 2013, Volume: 16, Issue:4

    Episodic memory deficits are a core feature of neurodegenerative disorders. Muscarinic M(1) receptors play a critical role in modulating learning and memory and are highly expressed in the hippocampus. We examined the effect of GSK1034702, a potent M(1) receptor allosteric agonist, on cognitive function, and in particular episodic memory, in healthy smokers using the nicotine abstinence model of cognitive dysfunction. The study utilized a randomized, double-blind, placebo-controlled, cross-over design in which 20 male nicotine abstained smokers were tested following single doses of placebo, 4 and 8 mg GSK1034702. Compared to the baseline (nicotine on-state), nicotine abstinence showed statistical significance in reducing immediate (p=0.019) and delayed (p=0.02) recall. GSK1034702 (8 mg) significantly attenuated (i.e. improved) immediate recall (p=0.014) but not delayed recall. None of the other cognitive domains was modulated by either nicotine abstinence or GSK1034702. These findings suggest that stimulating M(1) receptor mediated neurotransmission in humans with GSK1034702 improves memory encoding potentially by modulating hippocampal function. Hence, selective M(1) receptor allosteric agonists may have therapeutic benefits in disorders of impaired learning including Alzheimer's disease.

    Topics: Adult; Allosteric Regulation; Behavior, Addictive; Benzimidazoles; Cognition Disorders; Cross-Over Studies; Double-Blind Method; Humans; Male; Memory, Episodic; Middle Aged; Nicotine; Receptor, Muscarinic M1; Smoking; Smoking Cessation; Young Adult

2013

Other Studies

1 other study(ies) available for gsk-1034702 and Cognition-Disorders

ArticleYear
Muscarinic M1 receptor agonists: can they improve cognitive performance?
    The international journal of neuropsychopharmacology, 2013, Volume: 16, Issue:4

    Topics: Behavior, Addictive; Benzimidazoles; Cognition Disorders; Humans; Male; Memory, Episodic; Receptor, Muscarinic M1; Smoking Cessation

2013