gs-458967 and Migraine-Disorders

gs-458967 has been researched along with Migraine-Disorders* in 1 studies

Other Studies

1 other study(ies) available for gs-458967 and Migraine-Disorders

Article	Year
Late sodium current blocker GS967 inhibits persistent currents induced by familial hemiplegic migraine type 3 mutations of the SCN1A gene. The journal of headache and pain, 2019, Nov-15, Volume: 20, Issue:1 Familial hemiplegic migraine (FHM) is a group of genetic migraine, associated with hemiparesis and aura. Three causative different genes have been identified, all of which are involved in membrane ion transport. Among these, SCN1A encodes the voltage-gated Na. To obtain a more complete picture, here, we characterized by patch clamp approach the remaining 5 mutations (Q1489H, I1498M, F1499 L, M1500 V, F1661 L) in heterologous expression systems.. In conclusion, late Na Topics: Action Potentials; Epilepsy; HEK293 Cells; Humans; Migraine Disorders; Migraine with Aura; Mutation; NAV1.1 Voltage-Gated Sodium Channel; Neurons; Pyridines; Sodium; Triazoles	2019

Article

Year

Late sodium current blocker GS967 inhibits persistent currents induced by familial hemiplegic migraine type 3 mutations of the SCN1A gene.

The journal of headache and pain, 2019, Nov-15, Volume: 20, Issue:1

Familial hemiplegic migraine (FHM) is a group of genetic migraine, associated with hemiparesis and aura. Three causative different genes have been identified, all of which are involved in membrane ion transport. Among these, SCN1A encodes the voltage-gated Na. To obtain a more complete picture, here, we characterized by patch clamp approach the remaining 5 mutations (Q1489H, I1498M, F1499 L, M1500 V, F1661 L) in heterologous expression systems.. In conclusion, late Na

Topics: Action Potentials; Epilepsy; HEK293 Cells; Humans; Migraine Disorders; Migraine with Aura; Mutation; NAV1.1 Voltage-Gated Sodium Channel; Neurons; Pyridines; Sodium; Triazoles

2019