gs-458967 and Cardiomyopathy--Hypertrophic

gs-458967 has been researched along with Cardiomyopathy--Hypertrophic* in 1 studies

Other Studies

1 other study(ies) available for gs-458967 and Cardiomyopathy--Hypertrophic

Article	Year
Late sodium current inhibitors to treat exercise-induced obstruction in hypertrophic cardiomyopathy: an in vitro study in human myocardium. British journal of pharmacology, 2018, Volume: 175, Issue:13 In 30-40% of hypertrophic cardiomyopathy (HCM) patients, symptomatic left ventricular (LV) outflow gradients develop only during exercise due to catecholamine-induced LV hypercontractility (inducible obstruction). Negative inotropic pharmacological options are limited to β-blockers or disopyramide, with low efficacy and tolerability. We assessed the potential of late sodium current (I. The electrophysiological and mechanical responses to β-adrenoceptor stimulation were studied in human myocardium from HCM and control patients. Effects of I. In cardiomyocytes and trabeculae from 18 surgical septal samples of patients with obstruction, the selective I. Ranolazine and GS-967 reduced septal myocardium tension during simulated exercise in vitro and therefore have the potential to ameliorate symptoms caused by inducible obstruction in HCM patients, with some advantages over disopyramide and β-blockers. Topics: Adrenergic beta-Antagonists; Cardiomyopathy, Hypertrophic; Cohort Studies; Dose-Response Relationship, Drug; Exercise; Female; Humans; Male; Middle Aged; Myocardium; Pyridines; Ranolazine; Sodium; Sodium Channel Blockers; Triazoles	2018

Article

Year

Late sodium current inhibitors to treat exercise-induced obstruction in hypertrophic cardiomyopathy: an in vitro study in human myocardium.

British journal of pharmacology, 2018, Volume: 175, Issue:13

In 30-40% of hypertrophic cardiomyopathy (HCM) patients, symptomatic left ventricular (LV) outflow gradients develop only during exercise due to catecholamine-induced LV hypercontractility (inducible obstruction). Negative inotropic pharmacological options are limited to β-blockers or disopyramide, with low efficacy and tolerability. We assessed the potential of late sodium current (I. The electrophysiological and mechanical responses to β-adrenoceptor stimulation were studied in human myocardium from HCM and control patients. Effects of I. In cardiomyocytes and trabeculae from 18 surgical septal samples of patients with obstruction, the selective I. Ranolazine and GS-967 reduced septal myocardium tension during simulated exercise in vitro and therefore have the potential to ameliorate symptoms caused by inducible obstruction in HCM patients, with some advantages over disopyramide and β-blockers.

Topics: Adrenergic beta-Antagonists; Cardiomyopathy, Hypertrophic; Cohort Studies; Dose-Response Relationship, Drug; Exercise; Female; Humans; Male; Middle Aged; Myocardium; Pyridines; Ranolazine; Sodium; Sodium Channel Blockers; Triazoles

2018