griseofulvin and Skin-Neoplasms

Topics: Adrenal Cortex Hormones; Alopecia; Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Dermatitis; Dermatitis Herpetiformis; Dermatitis, Contact; Dermatology; Dermatomycoses; Drug Hypersensitivity; Ear, External; Female; Griseofulvin; Humans; Leg Ulcer; Nevus; Nevus, Pigmented; Psoriasis; Puerperal Disorders; Skin Neoplasms

Long-term control of mycosis fungoides in the tumour stage was achieved in one patient by daily demethylchlortetracycline therapy. On two occasions widespread nodules and tumours completely involuted within 1 month of initiating this therapy. A second patient showed complete resolution of his plaque stage mycosis fungoides after the institution of oral griseofulvin therapy for a chronic fungus infection. The disease reappeared upon stopping the griseofulvin and involuted upon its resumption. The observations are interpreted as evidence that reduction or eradication of a persistent bacterial or fungal antigen may have a remarkable ameliorative effect in selected mycosis fungoides patients.

Topics: Demeclocycline; Follow-Up Studies; Griseofulvin; Humans; Male; Middle Aged; Mycosis Fungoides; Skin Neoplasms

Topics: Adult; Aged; Female; Griseofulvin; Humans; Male; Mycosis Fungoides; Skin Neoplasms; Tetracycline

Topics: Adenoma; Animals; Benzopyrenes; Body Weight; Croton Oil; Depression, Chemical; Drug Synergism; Female; Griseofulvin; Lung Neoplasms; Lymphoma; Mammary Neoplasms, Experimental; Mice; Papilloma; Skin Neoplasms

Topics: Animals; Griseofulvin; Methylcholanthrene; Neoplasms, Experimental; Skin Neoplasms