griseofulvin and Skin-Diseases

Griseofulvin is the oral antifungal agent of choice for the treatment of dermatophytoses. This article reviews the history, pharmacokinetics, adverse reactions, and traditional therapeutic applications of griseofulvin. In addition, reports since 1960 of the use of the drug in the treatment of Raynaud's phenomenon, progressive systemic sclerosis, lichen planus, mycosis fungoides, herpes zoster, eosinophilic fasciitis, and molluscum contagiosum are discussed, noting the varying degree of therapeutic success.

Topics: Animals; Dermatomycoses; Griseofulvin; Humans; Skin Diseases

Topics: Acne Vulgaris; Alopecia; Balanitis; Candidiasis; Dermatitis, Occupational; Dermatomycoses; Diaper Rash; Drug-Related Side Effects and Adverse Reactions; Eczema; Erectile Dysfunction; Estrogens; Female; Glucocorticoids; Griseofulvin; Humans; Keloid; Male; Nystatin; Paronychia; Psoriasis; Scabies; Sexually Transmitted Diseases; Skin Diseases; Varicose Veins; Vitamins

Topics: Adolescent; Adult; Aged; Clinical Trials as Topic; Griseofulvin; Humans; Hypersensitivity, Delayed; Middle Aged; Skin Diseases; Tuberculin Test

Superficial fungal infections of the skin are among the most common infections encountered in medicine. The diagnosis is easily confirmed with simple office-based procedures. In certain clinical situations, the diagnosis can be elusive.. We analyzed clinical data on five patients who came in referral for treatment of a recalcitrant dermatosis.. All patients had their diagnosis confirmed by a positive potassium hydroxide preparation from skin scrapings or by a skin biopsy positive for fungal elements. All showed clinical improvement and ultimate resolution of their skin lesions with topical and/or systemic antifungal therapy.. Diagnosis can be complicated by previous use of corticosteroid-containing topical and/or systemic agents, a clinical history closely resembling that of a photosensitive disorder, and a lack of clinical-histopathologic correlation. Laboratory procedures and skin biopsy of an ambiguous appearing lesion can be diagnostic, but an accurate diagnosis is dependent on communication between the clinician and the pathologist. We recommend that office-based procedures be done early in treatment so that subsequent efforts can be directed toward providing appropriate therapies.

Topics: Adolescent; Antifungal Agents; Dermatomycoses; Diagnostic Errors; Female; Griseofulvin; Humans; Hydroxides; Ketoconazole; Male; Middle Aged; Potassium Compounds; Skin Diseases

Topics: Adolescent; Child; Female; Griseofulvin; Hair Diseases; Humans; Male; Mycoses; Skin Diseases; Sporotrichosis; Tinea

In nude mice grieofulvin given by intraperitoneal injections produces a severe porphyric state within 1 week. Compared with peroral administration of griseofulvin to produce experimental porphyria, this model is much more efficient and can be more easily controlled.

Topics: Animals; Chemical and Drug Induced Liver Injury; Chromatography, Liquid; Disease Models, Animal; Erythropoiesis; Griseofulvin; Injections, Intraperitoneal; Male; Mice; Mice, Nude; Porphyrias; Porphyrins; Protoporphyrins; Skin Diseases

Topics: Animals; Griseofulvin; Liver; Mice; Mice, Hairless; Porphyrias; Porphyrins; Skin; Skin Diseases; Species Specificity

Topics: Griseofulvin; Humans; Ketoconazole; Skin Diseases; Sweat; Sweating

Topics: Animals; beta Carotene; Canthaxanthin; Carotenoids; Dicarbethoxydihydrocollidine; Griseofulvin; Light; Mice; Mice, Nude; Porphyrias; Skin; Skin Diseases

In liver cells photodamage following externally added protoporphyrin affects predominantly membrane associated components, whereas photodamage by uroporphyrin also affects water-soluble components. Following excess endogenous production of porphyrins, protoporphyrin concentrates in the mitochondria and exerts its photodamaging effect primarily on the mitochondrial system, whereas uroporphyrin concentrates in lysosomes with release and inactivation of lysosomal enzymes when irradiated. The results may be of importance to explain the different skin lesions in porphyria cutanea tarda and erythropoietic protoporphyria.

Topics: Animals; Female; Griseofulvin; Hexachlorobenzene; Humans; Liver; Lysosomes; Male; Middle Aged; Mitochondria, Liver; Photosensitivity Disorders; Porphyrias; Porphyrins; Rats; Rats, Inbred Strains; Skin Diseases

After a report of clinical effectiveness, four adult patients with monilethrix were treated with griseofulvin for six months at an orally administered dose of 500 mg (microsize) per day. No objective or subjective improvement was observed.

Topics: Adolescent; Adult; Female; Griseofulvin; Hair; Humans; Male; Skin Diseases

A case of leukonychia is reported, in which Trichophyton rubrum was isolated from the nail plates and interdigital spaces of the toes. Treatment consisted of oral griseofulvin, which produced appreciable improvement after ten months' therapy.

Topics: Fingers; Griseofulvin; Humans; Male; Middle Aged; Nails; Skin Diseases; Tinea; Toes

Topics: Amphotericin B; Antifungal Agents; Candida albicans; Candidiasis; Candidiasis, Oral; Diaper Rash; Drug Resistance, Microbial; Female; Griseofulvin; Humans; Male; Mouth Diseases; Nystatin; Ointments; Paronychia; Pruritus Ani; Skin Diseases; Tinea; Tinea Pedis; Tinea Versicolor

Topics: Child, Preschool; Depression, Chemical; Griseofulvin; Hair; Humans; Male; Mitosis; Skin Diseases; Tinea Capitis; Trichophyton

Topics: Griseofulvin; Hair; Skin Diseases; Tinea Capitis

Topics: Contraceptives, Oral; Ethacrynic Acid; Furosemide; Griseofulvin; Hearing Disorders; Humans; Jaundice; Skin Diseases; Sulfonamides; Taste Disorders

Topics: Amphotericin B; Candidiasis; Diabetes Complications; Diabetic Angiopathies; Foot Diseases; Glucose; Griseofulvin; Humans; Injections, Intramuscular; Nystatin; Pyoderma; Skin Diseases; Skin Manifestations; Skin Ulcer; Tolnaftate; Xanthomatosis

Topics: Acne Vulgaris; Adrenocorticotropic Hormone; Anti-Bacterial Agents; Antineoplastic Agents; Eczema; Female; Glucocorticoids; Gonorrhea; Griseofulvin; Humans; Ion Exchange Resins; Leprosy; Male; Mycoses; Ointments; Pemphigus; Psoriasis; Skin Diseases; Sulfonamides

Topics: Complement System Proteins; Fluocinolone Acetonide; Griseofulvin; Humans; Male; Middle Aged; Myxedema; Skin Diseases; Triamcinolone Acetonide

Fourteen cases are described in which the local application of corticosteroid preparations to ringworm infections of the skin have resulted in unusual clinical pictures. A kerion-like lesion due to Trichophyton rubrum, intertriginous infections simulating candidiasis and due to Epidermophyton floccosum, and pictures resembling poikiloderma, papular rosacea, and indeterminate leprosy are among the changes that were seen in these patients.

Topics: Adolescent; Adult; Aged; Betamethasone; Diagnosis, Differential; Eczema; Epidermophyton; Female; Fluocinolone Acetonide; Glucocorticoids; Griseofulvin; Humans; Keratins; Male; Middle Aged; Skin Diseases; Tinea; Triamcinolone Acetonide; Trichophyton; Valerates

Topics: Dermatologic Agents; Griseofulvin; Humans; Skin Diseases

Topics: Adolescent; Adult; Child; Egypt; Female; Griseofulvin; Humans; Male; School Health Services; Skin Diseases

Topics: Actinomycosis; Adult; Amphotericin B; Aspergillosis; Blastomycosis; Candidiasis, Vulvovaginal; Child; Cryptococcosis; Dermatomycoses; Female; Griseofulvin; Humans; Lung Diseases, Fungal; Mycetoma; Mycoses; Nails; Nocardia Infections; Nystatin; Skin Diseases; Sporotrichosis; Stilbamidines; Thallium; Tinea Pedis

Topics: Antifungal Agents; Dermatomycoses; Griseofulvin; Humans; Skin Diseases

Topics: Drug Therapy; Griseofulvin; Onychomycosis; Skin Diseases; Tinea; Tinea Favosa

Topics: Acne Vulgaris; Alopecia; Griseofulvin; Humans; Skin Diseases; Steroids; Syphilis

Topics: Disease; Griseofulvin; Scalp; Skin Diseases; Tinea

Topics: Appointments and Schedules; Disease; Griseofulvin; Humans; Scalp; Skin Diseases; Tinea; Tinea Capitis

Topics: Adrenal Cortex Hormones; Aminopterin; Anti-Bacterial Agents; Antifungal Agents; Antimalarials; Antineoplastic Agents; Chelating Agents; Dermabrasion; Dermatologic Agents; Dermatology; Griseofulvin; Histamine H1 Antagonists; Humans; Melanoma; Methotrexate; Methoxsalen; Ointments; Perfusion; Phenols; Skin Diseases; Vitamin A

Topics: Disease; Griseofulvin; Humans; Scalp; Skin Diseases; Tinea Favosa

Topics: Disease; Griseofulvin; Scalp; Skin Diseases; Tinea

Topics: Griseofulvin; Mycoses; Skin Diseases

Topics: Dermatomycoses; Disease; Follow-Up Studies; Griseofulvin; Scalp; Skin Diseases; Tinea; Tinea Capitis

Topics: Disease; Griseofulvin; Scalp; Skin Diseases; Tinea; Tinea Capitis

Topics: Animals; Dermatitis; Dermatomycoses; Griseofulvin; Skin Diseases

Topics: Disease; Griseofulvin; Scalp; Skin Diseases; Tinea; Tinea Capitis

Topics: Disease; Griseofulvin; Scalp; Skin Diseases; Tinea; Tinea Capitis

Topics: Disease; Griseofulvin; Scalp; Skin Diseases; Tinea; Tinea Capitis

Topics: Disease; Griseofulvin; Scalp; Skin Diseases; Tinea; Tinea Capitis

Topics: Disease; Griseofulvin; Microsporum; Scalp; Skin Diseases; Tinea

Topics: Disease; Griseofulvin; Scalp; Skin Diseases; Tinea; Tinea Capitis

Topics: Disease; Griseofulvin; Scalp; Skin Diseases; Tinea; Tinea Capitis

Topics: Disease; Griseofulvin; Scalp; Skin Diseases; Tinea

Topics: Disease; Griseofulvin; Scalp; Skin Diseases; Tinea; Tinea Capitis

Topics: Griseofulvin; Mycoses; Skin Diseases

Topics: Disease; Griseofulvin; Scalp; Skin Diseases; Tinea

Topics: Disease; Griseofulvin; Scalp; Skin Diseases; Tinea Capitis

Topics: Dermatomycoses; Griseofulvin; Mycoses; Skin Diseases

Topics: Anti-Bacterial Agents; Dermatology; Griseofulvin; Skin Diseases

Topics: Antifungal Agents; Dermatomycoses; Fungicides, Industrial; Griseofulvin; Humans; Mycoses; Skin Diseases

Topics: Antifungal Agents; Disease; Fungicides, Industrial; Griseofulvin; Scalp; Skin Diseases; Tinea

Topics: Antifungal Agents; Disease; Fungicides, Industrial; Griseofulvin; Humans; Scalp; Skin Diseases; Tinea; Tinea Capitis

Topics: Anti-Bacterial Agents; Antifungal Agents; Griseofulvin; Mycoses; Skin; Skin Diseases

Topics: Antifungal Agents; Dermatology; Griseofulvin; Humans; Skin Diseases

Topics: Griseofulvin; Mycoses; Skin; Skin Diseases

Topics: Disease; Griseofulvin; Microsporum; Scalp; Skin Diseases; Tinea

Topics: Dermatomycoses; Fungi; Griseofulvin; Mycoses; Skin Diseases

Topics: Disease; Griseofulvin; Microsporum; Scalp; Skin Diseases; Tinea; Tinea Capitis

Topics: Griseofulvin; Mycoses; Skin Diseases