griseofulvin and Psoriasis

Topics: Acne Vulgaris; Alopecia; Balanitis; Candidiasis; Dermatitis, Occupational; Dermatomycoses; Diaper Rash; Drug-Related Side Effects and Adverse Reactions; Eczema; Erectile Dysfunction; Estrogens; Female; Glucocorticoids; Griseofulvin; Humans; Keloid; Male; Nystatin; Paronychia; Psoriasis; Scabies; Sexually Transmitted Diseases; Skin Diseases; Varicose Veins; Vitamins

Topics: Blood Cell Count; Drug Eruptions; Drug Hypersensitivity; Gout; Griseofulvin; Hepatomegaly; Herpes Zoster; Liver Diseases; Mycoses; Nails; Neurology; Periarthritis; Psoriasis; Reflex Sympathetic Dystrophy; Rheumatic Diseases; Splenomegaly; Toxicology

Topics: Adrenal Cortex Hormones; Alopecia; Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Dermatitis; Dermatitis Herpetiformis; Dermatitis, Contact; Dermatology; Dermatomycoses; Drug Hypersensitivity; Ear, External; Female; Griseofulvin; Humans; Leg Ulcer; Nevus; Nevus, Pigmented; Psoriasis; Puerperal Disorders; Skin Neoplasms

Dermatophytids are immunologically mediated dermatologic presentations secondary to sensitization to a dermatophyte infection. They are most frequently associated with toe-web intertrigo and usually present as localized, palmar, pruriginous vesicular eruptions. We report three original cases of generalized exanthematous pustular dermatophytid associated with kerions.. Two boys aged 11 and 6 years, and one girl aged 6 years initially presented with kerion secondary to Trichophyton tonsurans (case 1), Trichophyton soudanense (case 2) and Trichophyton mentagrophytes (case 3), respectively. Two to three days after initiation of griseofulvin treatment, all patients presented with a pustular eruption extending from the head to the trunk, associated in one case with fever of 39°C and inflammatory chondritis. Samples obtained from the pustular lesions were sterile, serum inflammatory markers were within the normal range and skin lesions resolved on oral corticosteroid treatment (prednisone 0.75 mg/kg, case 1) or high-potency topical steroids (cases 2 and 3) given as an adjunct to griseofulvin treatment (19 to 23 mg/kg/d).. Dermatophytids occur during the acute phase of infection or within a few days of treatment initiation. Lesions are remote from the infection site, contain no dermatophyte, and resolve after treatment of the infection. We report three original cases of generalized exanthematous pustular dermatophytid, associated in one case with fever and inflammatory chondritis. The main differential diagnosis is acute generalized exanthematous pustulosis secondary to antifungal drugs. Differences in clinical presentation between the two enable the appropriate diagnosis to be made as well as continued use of the antifungal medication needed to cure the patient. General or topical steroids may also be used in combination.

Topics: Acute Generalized Exanthematous Pustulosis; Antifungal Agents; Child; Diagnosis, Differential; Drug Eruptions; Female; Fever; Griseofulvin; Humans; Male; Mali; Osteochondritis; Prednisone; Psoriasis; Senegal; Tinea Capitis; Trichophyton

An improved method suitable for the determination of 8-methoxypsoralen in the range 50-1500 ng/ml in the plasma of psoriatic patients undergoing PUVA (psoralens and long-wave ultraviolet light) therapy is proposed. A 5-ml aliquot of plasma containing sodium citrate as anticoagulant was centrifuged, griseofulvin was added as internal standard and the sample was denatured with acetonitrile. The supernatant was applied to C18 cartridges and 8-methoxypsoralen was eluted with methanol. The evaporated eluate was reconstituted in the mobile phase for high-performance liquid chromatography (HPLC) and applied to the HPLC column: mobile phase, acetonitrile-0.01 M phosphoric acid (34:66); flow-rate, 1 ml/min; temperature, 40 degrees C; column, Spherisorb 5 ODS, 100 mm x 4.6 mm I.D., 5 microns particle size; UV detection at 248 nm; detection limit, 15 ng/ml of plasma.

Topics: Chromatography, High Pressure Liquid; Griseofulvin; Humans; Methoxsalen; Psoriasis; PUVA Therapy

Most nail disorders seen by primary care physicians are due to maceration, dryness, trauma, or infection. Some cases may be treated simply by having the patient remove a bandage to allow the skin to dry; other cases, such as subungual abscess, require local anesthesia and drainage for relief. Fungal infections may need to be treated for as long as a year. Patients with a tumor under the nail should be referred to a specialist.

Topics: Chronic Disease; Griseofulvin; Humans; Infections; Nail Diseases; Paronychia; Psoriasis; Warts

Topics: Adolescent; Adult; Aged; Balneology; Diphenhydramine; Drug Evaluation; Drug Hypersensitivity; Drug Synergism; Female; Griseofulvin; Humans; Male; Middle Aged; Nicotinic Acids; Ointments; Psoriasis; Riboflavin; Thiamine

Topics: Acne Vulgaris; Adrenocorticotropic Hormone; Anti-Bacterial Agents; Antineoplastic Agents; Eczema; Female; Glucocorticoids; Gonorrhea; Griseofulvin; Humans; Ion Exchange Resins; Leprosy; Male; Mycoses; Ointments; Pemphigus; Psoriasis; Skin Diseases; Sulfonamides

Topics: Acid Phosphatase; Adult; Aged; Alkaline Phosphatase; Biopsy; Female; Griseofulvin; Histocytochemistry; Humans; Male; Middle Aged; Psoriasis; Skin; Succinate Dehydrogenase

Topics: Adolescent; Adult; Arthrodermataceae; Diagnosis, Differential; Eczema; Epidermophyton; Female; Folliculitis; Griseofulvin; Humans; Leg Dermatoses; Psoriasis; Tinea; Trichophyton

Topics: Adrenal Cortex Hormones; Griseofulvin; Humans; Nails; Nystatin; Onychomycosis; Paronychia; Psoriasis; Sulfacetamide; Thymol

Topics: Female; Griseofulvin; Humans; Male; Psoriasis

Topics: Aminopterin; Dermatitis; Dermatitis, Contact; Dermatomycoses; Drug Therapy; Griseofulvin; Psoriasis; Rubber; Sulfides; Toxicology

Topics: Adolescent; Child; Drug Therapy; Geriatrics; Griseofulvin; Keratins; Leg Ulcer; Neurodermatitis; Pharmacology; Psoriasis; Tinea

Topics: Acne Vulgaris; Bandages; Dermatology; Dermatomycoses; Diagnosis, Differential; Eczema; Fluocinolone Acetonide; Flurandrenolone; Griseofulvin; Humans; Keratoacanthoma; Occlusive Dressings; Plastics; Polyethylenes; Psoriasis; Steroids; Sunburn; Television; Tinea; Triamcinolone Acetonide

Topics: Adolescent; Copper; Dermatitis; Dermatomycoses; Diagnosis, Differential; Drug Therapy; Erythema; Griseofulvin; Humans; Lupus Erythematosus, Discoid; Psoriasis; Skin Diseases, Genetic; Triamcinolone

Topics: Griseofulvin; Humans; Nail Diseases; Nails; Onychomycosis; Psoriasis; Tinea