griseofulvin and Nail-Diseases

Topics: Anti-Inflammatory Agents; Antifungal Agents; Arthrodermataceae; Dermatomycoses; Epidermal Growth Factor; Epidermis; Griseofulvin; Hair; Hair Diseases; Host-Parasite Interactions; Humans; Immunity, Innate; Nail Diseases; Spores, Fungal; Tinea Capitis

We conducted a double-blind comparative study of terbinafine, 250 mg twice daily, versus griseofulvin, 500 mg twice daily, for 6 weeks in chronic dermatophyte infections of the feet or hands. All but three patients (total 31) had Trichophyton rubrum infection. At 12-week follow-up, 100% of the terbinafine-treated group were free from infection compared with 45% of those treated with griseofulvin. Therapy in 75% of the terbinafine-treated group and in 35% of those given griseofulvin was rated as effective overall at long-term follow-up, although these differences were not statistically significant. Six months after treatment all nine patients whose skin had cleared with terbinafine therapy remained in remission versus only one of seven patients treated with griseofulvin. None of the patients in either group experienced serious adverse effects.

Topics: Antifungal Agents; Chronic Disease; Double-Blind Method; Female; Follow-Up Studies; Foot Dermatoses; Griseofulvin; Hand Dermatoses; Humans; Male; Nail Diseases; Naphthalenes; Recurrence; Terbinafine; Tinea

Topics: Antifungal Agents; Griseofulvin; Humans; Medical Illustration; Nail Diseases; Nails; Photography; Tinea; Treatment Outcome

Topics: Adult; Contraceptives, Oral, Hormonal; Contraceptives, Oral, Synthetic; Dermatomycoses; Drug Interactions; Ethinyl Estradiol; Ethinyl Estradiol-Norgestrel Combination; Female; Griseofulvin; Humans; Nail Diseases; Norgestrel; Pregnancy

Most nail disorders seen by primary care physicians are due to maceration, dryness, trauma, or infection. Some cases may be treated simply by having the patient remove a bandage to allow the skin to dry; other cases, such as subungual abscess, require local anesthesia and drainage for relief. Fungal infections may need to be treated for as long as a year. Patients with a tumor under the nail should be referred to a specialist.

Topics: Chronic Disease; Griseofulvin; Humans; Infections; Nail Diseases; Paronychia; Psoriasis; Warts

Topics: Aged; Griseofulvin; Humans; Hypohidrosis; Male; Nail Diseases; Syndrome; Vitamin E

The antibiotic griseofulvin has been used for more than two decades in the treatment of dermatophyte-induced mycoses. During the first 10 years of use griseofulvin-resistant dermatophytes were demonstrated only in a few cases. During the seventies we did not find an increase in these strains. During this period of time the total number of dermatophytes studied by us was 489 of which 5 proved resistant, that is 4 strains of Trichophyton rubrum and one strain of Trichophyton mentagrophytes, which were still growing at a concentration of 100 gamma griseofulvin per ml culture medium. We consider these strains to have a secondary resistance and did not observe dermatophytes with a primary resistance. Accordingly, the number of non-responders cannot generally be explained by the presence of resistant dermatophytes, but rather by other reasons which have already been discussed. For the time being the problem of an increasing incidence of griseofulvin-resistant dermatophytes does not exist.

Topics: Arthrodermataceae; Dermatomycoses; Drug Resistance, Microbial; Epidermophyton; Griseofulvin; Humans; Microbial Sensitivity Tests; Nail Diseases; Recurrence; Tinea

Topics: Adult; Candidiasis; Dermatomycoses; Griseofulvin; Humans; Imidazoles; Nail Diseases; Onychomycosis; Paronychia; Selenium; Tinea Capitis; Tinea Pedis; Tinea Versicolor

Topics: Clinical Protocols; Griseofulvin; Nail Diseases; Nails; Onychomycosis; Tinea

Topics: Griseofulvin; Humans; Nail Diseases; Nails; Onychomycosis; Tinea

Topics: Griseofulvin; Nail Diseases; Nails; Onychomycosis

Topics: Administration, Oral; Anti-Bacterial Agents; Candida; Candidiasis; Griseofulvin; Nail Diseases; Nails

Topics: Griseofulvin; Nail Diseases; Nails; Onychomycosis; Tinea; Tinea Pedis

Comprehensive studies and numerous clinical reports have shown that griseofulvin orally in a dose of 1 gm. daily is an effective treatment for superficial fungous infections of the skin, hair and nails. The drug is not effective against yeast infections (moniliasis), bacterial infections or most of the deep fungous infections. Duration of treatment varies with the site of infection, glabrous skin, crotch and scalp responding within four to five weeks. Infections of palms, soles and nails require a considerably longer time, palms healing more quickly than soles and fingernails more quickly than toenails, which may require up to a year of continuous treatment. Auxiliary measures such as clipping hair, removing infected nail tissue and topical fungicides shorten the duration of treatment. No serious side effects have been reported. Minor discomforts such as headaches and mild rashes occur in some cases. Observations of a series of 49 patients with superficial fungous infections, especially hand, foot and nail infections due to Trichophyton rubrum, confirmed these reports taken from the literature. Attempts to use a reduced dosage schedule did not prove satisfactory.

Topics: Arecaceae; Dermatomycoses; Foot; Griseofulvin; Humans; Nail Diseases; Skin; Wound Healing

Topics: Dermatomycoses; Griseofulvin; Humans; Nail Diseases; Nails; Skin; Tinea

Topics: Griseofulvin; Mycoses; Nail Diseases; Nails; Onychomycosis

Topics: Griseofulvin; Mycoses; Nail Diseases; Nails; Onychomycosis; Research

Topics: Dermatomycoses; Griseofulvin; Nail Diseases; Nails; Onychomycosis; Tinea

Topics: Griseofulvin; Nail Diseases; Nails; Onychomycosis; Tinea

Topics: Griseofulvin; Nail Diseases; Nails; Onychomycosis; Tinea

Griseofulvin, a new orally administered antifungal antibiotic which has proved to be effective for the treatment of a wide variety of superficial fungus infections of man, was used in the treatment of 51 patients with infections of the toenails due to T. rubrum. Thirty-four of the patients were treated with griseofulvin alone and seven were treated with griseofulvin combined with surgical avulsion of all involved toenails. The remaining ten had bilateral infections, and avulsion was done on one foot but not the other before griseofulvin therapy was begun. Of 34 patients who were treated with griseofulvin alone, few had complete cure even after prolonged treatment. Some nails showed improvement for a time, then no further gain; some showed no improvement; some showed resistant wedges of infection which penetrated proximally toward the posterior nail fold.In the instances of surgical avulsion, clinically normal nails regrew during griseofulvin therapy. This simple procedure, with thorough removal of all underlying keratinous debris, apparently did away with foci of possible reinfection. The results of the study indicated that surgical avulsion of the toenails in combination with griseofulvin therapy is an effective and practical method of treating onychomycosis of the toenails due to T. rubrum.

Topics: Antifungal Agents; Dermatomycoses; Foot; Fractures, Bone; Griseofulvin; Humans; Male; Mycoses; Nail Diseases; Nails; Onychomycosis

Topics: Griseofulvin; Nail Diseases; Nails; Onychomycosis; Tinea

Topics: Griseofulvin; Nail Diseases; Nails; Tinea

Topics: Communicable Diseases; Griseofulvin; Nail Diseases; Nails; Tinea

Topics: Foreign Bodies; Griseofulvin; Hemorrhage; Humans; Nail Diseases; Skin

Topics: Griseofulvin; Humans; Nail Diseases; Nails; Onychomycosis; Tinea; Trichophyton

Topics: Griseofulvin; Nail Diseases; Nails; Onychomycosis; Tinea

Topics: Griseofulvin; Nail Diseases; Nails; Tinea

Topics: Griseofulvin; Humans; Nail Diseases; Nails; Onychomycosis; Psoriasis; Tinea