griseofulvin and Mycetoma

Topics: Adult; Antifungal Agents; Aspergillosis; Aspergillus; Aspergillus flavus; Benzene Derivatives; Candida albicans; Clinical Trials as Topic; Female; Griseofulvin; Humans; Imidazoles; Male; Microbial Sensitivity Tests; Middle Aged; Mitosporic Fungi; Mycetoma; Paronychia

Dermatophytic pseudomycetoma is a subcutaneous fungal infection by Microsporum canis.. This work describes a case of dermatophytic pseudomycetoma in a Persian cat.. A 3-year old female Persian cat showing alopecia, scaling and ulcerated nodules throughout the body, with presence of ulcerated nodules with yellow granular discharges on the dorsum, close to the tail. Mycological and histopathological examinations were realized.. Diagnosis of dermatophytic pseudomycetoma was established. The cat was treated with griseofulvin, and surgical excision was carried out. Response to therapy was effective during the first months, during which a reduction in nodule frequency was observed. However, despite maintaining the therapy levels, the lesions relapsed and progressed to the point of causing the animal's death.. The clinic evolution showed the progressive and recurrent character of dermatophytic pseudomycetoma.

Topics: Animals; Antifungal Agents; Cat Diseases; Cats; Combined Modality Therapy; Dermatomycoses; Diagnosis, Differential; Disease Progression; Female; Griseofulvin; Microsporum; Mycetoma; Recurrence

Polymorphonuclear leucocytes are the predominant cell type in the inflammatory infiltrate around mycetoma grains. Human leucocyte chemotaxis using cells from healthy subjects has been demonstrated using cytoplasmic antigens from 3 mycetoma agents: Madurella mycetomatis and Pseudallescheria boydii, both fungi, and Streptomyces somaliensis, an actinomycete. There was a statistically insignificant increase in chemotaxis in the presence of ketoconazole, but griseofulvin was a potent inhibitor of leucocyte movement. Griseofulvin has been used to improve the clinical appearances in eumycetoma (fungal mycetoma) cases which respond poorly to antifungal chemotherapy and it is suggested that its effect in this condition depends, in part, on its ability to inhibit leucocyte aggregation around mycetoma grains.

Topics: Antigens, Fungal; Chemotaxis, Leukocyte; Griseofulvin; Humans; Ketoconazole; Mycetoma; Neutrophils

A 25-year-old black man had generalized tinea corporis for 19 years and had associated subcutaneous mycotic granuloma of the scalp and nape of the neck for 17 years. The dermatophyte from the skin was identified as Microsporum audouinii and responded to oral griseofulvin treatment. Biopsy specimens of the subcutaneous nodules revealed yellowish granules containing masses of irregularly septated hyaline hyphae with frequent vesicles. This fungus differed only in gross colonial morphology from the M. audouinii isolated from the skin and has also been identified as M. audouinii. The subcutaneous nodules were treated and controlled by amphotericin B and are still under treatment.

Topics: Adult; Amphotericin B; Griseofulvin; Humans; Male; Microsporum; Mycetoma; Skin; Tinea

Topics: Actinomycosis; Amphotericin B; Blastomycosis; Candida albicans; Candidiasis, Cutaneous; Chromoblastomycosis; Coccidioidomycosis; Cryptococcosis; Dermatomycoses; Flucytosine; Griseofulvin; Histoplasmosis; Mucormycosis; Mycetoma; Sporotrichosis; Tinea Capitis; Tinea Pedis; Tinea Versicolor

Two cases of black grain mycetoma, one owing to Madurella grisea and the other due to M. mycetomii have been reported. The clinical features appear to be less florid than that occurring in actinomycotic mycetoma. There was no bone involvement in either of the two cases. These two are the first cases of black grain mycetoma from our institution.

Topics: Adult; Dapsone; Griseofulvin; Humans; India; Male; Middle Aged; Mitosporic Fungi; Mycetoma

Topics: Agglutination Tests; Complement Fixation Tests; Culture Media; Fibroblasts; Foot Diseases; Griseofulvin; Humans; Immunodiffusion; Lymphocytes; Macrophages; Male; Middle Aged; Mycetoma; Nails; Plasma Cells; Tinea; Toes; Trichophyton

Topics: Adult; Female; Griseofulvin; Histocytochemistry; Humans; Mexico; Microscopy, Electron; Mitosporic Fungi; Mycetoma; Succinate Dehydrogenase; Texas

Topics: Aged; Amphotericin B; California; Dapsone; Griseofulvin; Humans; Male; Mitosporic Fungi; Mycetoma

Topics: Actinomycosis; Adult; Amphotericin B; Aspergillosis; Blastomycosis; Candidiasis, Vulvovaginal; Child; Cryptococcosis; Dermatomycoses; Female; Griseofulvin; Humans; Lung Diseases, Fungal; Mycetoma; Mycoses; Nails; Nocardia Infections; Nystatin; Skin Diseases; Sporotrichosis; Stilbamidines; Thallium; Tinea Pedis

Topics: Diagnosis; Drug Therapy; Griseofulvin; Humans; Mycetoma; Nocardia; Nocardia Infections; Surgical Procedures, Operative

Topics: Griseofulvin; Mycetoma; Mycoses