griseofulvin and Lupus-Erythematosus--Systemic

Topics: Aging; Animals; Child; Chloral Hydrate; Dogs; Drug Antagonism; Drug Resistance, Microbial; Endoplasmic Reticulum; Enzyme Induction; Female; Genetics, Microbial; Griseofulvin; Humans; Hypnotics and Sedatives; Infant, Newborn; Insecticides; Lupus Erythematosus, Systemic; Male; Mice; Microscopy, Electron; Microsomes; Molecular Biology; Penicillinase; Phenobarbital; Porphyrias; Rabbits; Rats; Steroids; Warfarin

Several factors are known to trigger acute manifestations of lupus erythematosus (drugs, ultraviolet radiation, bacterial or viral infections, pregnancy), but fungal infections have never been reported to induce lupus-like lesions. We describe 2 children with tinea capitis caused by Trichophyton mentagrophytes(TM), who developed transient skin and serological manifestations of systemic lupus erythematosus.. Case 1, a 3-year-old girl, had a kerion due to TM transmitted by an octodon, and a facial skin eruption suggestive of systemic lupus erythematosus. Antinuclear antibodies (ANA) were positive at 1:250. After griseofulvin treatment, the lupus-like rash completely regressed, and the ANA titre decreased. Case 2, a 4-year-old girl, had occipital kerion and an annular scaly erythema on the shoulder caused by TM. She also had a non-scaly rash on the face and a recent history of photosensitivity. The ANA titre was positive at 1:8,000. Cutaneous lesions disappeared after an 8-week griseofulvin therapy, and ANA titres decreased progressively.. 'New pets' are usually the vectors of TM, especially familiar rodents like the degu of Chile (also named octodon). In our 2 cases, lupus-like rashes began before the onset of griseofulvin treatment, suggesting a pathogenic role of the dermatophyte. A wide variety of lesions named 'mycides' was described several decades ago associated with TM infections. We hypothesize that these mycides and the TM-induced lupus-like lesions reported in our 2 cases could represent the same entity.

Topics: Animals; Animals, Domestic; Antifungal Agents; Child, Preschool; Female; Griseofulvin; Humans; Lupus Erythematosus, Systemic; Rodentia; Tinea Capitis; Treatment Outcome; Trichophyton

We report a 16-year-old male who developed nephrotic syndrome related to membranous glomerulopathy with clinical and serological evidence of systemic lupus erythematosus after treatment with griseofulvin. To our knowledge, this is the first case of griseofulvin-exacerbated lupus in which nephrotic syndrome has been observed.

Topics: Adolescent; Antibodies, Antinuclear; Antifungal Agents; Fluorescent Antibody Technique, Indirect; Griseofulvin; Humans; Kidney Glomerulus; Lupus Erythematosus, Systemic; Male; Microscopy, Electron; Nephrotic Syndrome; Tinea Capitis

This article reports the cases of two patients in whom a widespread dermatophyte infection mimicked the cutaneous lesions of their underlying collagen vascular disease. Griseofulvin may be associated with an increased incidence of adverse cutaneous reactions in patients with systemic lupus erythematosus. One patient with systemic lupus erythematosus developed erythema multiforme after taking griseofulvin.

Topics: Adult; Aged; Dermatomycoses; Diagnosis, Differential; Drug Eruptions; Female; Griseofulvin; Humans; Lupus Erythematosus, Systemic; Microsporum; Tinea; Trichophyton

Topics: Adult; Ampicillin; Erythromycin; Female; Griseofulvin; Humans; Lupus Erythematosus, Systemic; Respiratory Tract Infections

Because griseofulvin is one of the safest systemic medications, its side effects are often forgotten. This paper serves as a reminder that griseofulvin can precipitate or exacerbate lupus erythematosus. Two patients are described: one had a photosensitivity reaction to griseofulvin which precipitated discoid LE skin lesions, without any previous evidence of LE. The other, who had known systemic LE, developed a systemic reaction, consisting of fever and malasise.

Topics: Griseofulvin; Humans; Lupus Erythematosus, Discoid; Lupus Erythematosus, Systemic; Male; Middle Aged; Photosensitivity Disorders

Topics: Biopsy; Collagen Diseases; Dermatomyositis; Diagnosis, Differential; Erythema; Facial Dermatoses; Female; Griseofulvin; Humans; Hydroxides; Lupus Erythematosus, Systemic; Middle Aged; Physical Examination; Potassium; Skin; Telangiectasis; Tinea; Tolnaftate; Trichophyton

Topics: Administration, Oral; Adolescent; Adult; Age Factors; Aged; Antifungal Agents; Child; Dermatitis, Contact; Facial Dermatoses; Female; Griseofulvin; Humans; Lupus Erythematosus, Discoid; Lupus Erythematosus, Systemic; Male; Middle Aged; Time Factors; Tinea

Topics: Adolescent; Female; Griseofulvin; Humans; Lupus Erythematosus, Systemic; Tinea; Trichophyton

Topics: Adult; Female; Griseofulvin; Humans; Lupus Erythematosus, Systemic; Male; Middle Aged

Topics: Adolescent; Adult; Drug Eruptions; Female; Griseofulvin; Humans; Lupus Erythematosus, Systemic; Male

Topics: Drug Hypersensitivity; Griseofulvin; Humans; Lupus Erythematosus, Systemic; Toxicology

Topics: Griseofulvin; Humans; Lupus Erythematosus, Systemic; Tinea; Trichophyton