griseofulvin and Hypersensitivity

The atopic chronic dermatophytosis syndrome is uncommon in children. Clinical and immunological characteristics are reviewed. The infecting fungus is Trichophyton rubrum, occasionally Trichophyton interdigitale.

Topics: Child; Griseofulvin; Humans; Hypersensitivity; Male; Skin Tests; Tinea; Tinea Pedis

One hundred and six patients with chronic dermatophytosis unresponsive to griseofulvin were studied. Trichophyton rubrum was the causative organism in 93% of cases. Chronic dermatophyte infections caused by organisms other than T. rubrum occurred predominantly, but not exclusively, in patients with underlying diseases. Forty-nine percent of the patients had a personal or family history of atopy but other abnormalities included disorders of keratinization, collagen vascular disease and systemic steroid therapy. The commonest sites of infection were the palms and soles, as opposed to toe webs or groins in control patients with griseofulvin-responsive dermatophyte infections. A significant proportion of chronically infected patients had raised IgE levels. Only 11% of the chronically infected group showed delayed hypersensitivity responses to intradermal trichophytin but 58% showed immediate hypersensitivity responses to trichophytin as well as other fungal and non-fungal allergens.

Topics: Adolescent; Adult; Aged; Child; Chronic Disease; Dermatomycoses; Female; Griseofulvin; Humans; Hypersensitivity; Hypersensitivity, Immediate; Immunoglobulin E; Male; Middle Aged; Skin Tests; Tinea

A proportion of dermatophyte infections fail to respond to normally adequate courses of griseofulvin and topical antifungal therapy. The organism Trichophyton rubrum was isolated from 96% of 50 patients studied, but no instances of in vitro resistance were seen. Of these patients, 57% had an underlying condition, commonly hay fever/asthma, atopic eczema, collagen disease or ichthyosis. Defective delayed type hypersensitivity responses and leucocyte migration inhibition to the specific antigen, trichophytin, were demonstrated. Immediate type hypersensitivity was seen in 58% and this was partially suppressible with chlorpheniramine and cimetidine. The relationship between these abnormalities and failure of treatment is discussed.

Topics: Adolescent; Adult; Aged; Cell Migration Inhibition; Chronic Disease; Collagen Diseases; Dermatomycoses; Female; Griseofulvin; Humans; Hypersensitivity; Ichthyosis; Immunity, Cellular; Male; Middle Aged; Trichophyton

Topics: Child; Female; Griseofulvin; Humans; Hypersensitivity; Microsporum; Skin; Skin Manifestations; Soil Microbiology; Tinea

Topics: Griseofulvin; Humans; Hypersensitivity

Topics: Anti-Bacterial Agents; Fungi; Griseofulvin; Hypersensitivity; Mycoses; Nystatin

Topics: Griseofulvin; Humans; Hypersensitivity; Tinea

Topics: Griseofulvin; Hypersensitivity; Immune System Diseases; Medical Records