griseofulvin and Candidiasis--Chronic-Mucocutaneous

Topics: Candidiasis; Candidiasis, Chronic Mucocutaneous; Candidiasis, Oral; Chemical Phenomena; Chemistry; Chromoblastomycosis; Coccidioidomycosis; Cryptococcosis; Dermatomycoses; Drug Interactions; Griseofulvin; Histoplasmosis; Humans; Ketoconazole; Onychomycosis; Paracoccidioidomycosis; Sporotrichosis; Tinea Versicolor

This article summarizes the diseases of the nail caused by fungi. The clinical appearance of the diseases are the key to understanding their causes. Therapy is updated. Specifically discussed are distal subungual onychomycosis, white superficial onychomycosis, proximal subungual onychomycosis, and onychomycosis in chronic mucocutaneous candidiasis.

Topics: Adult; Candida albicans; Candidiasis, Chronic Mucocutaneous; Foot Dermatoses; Glutaral; Griseofulvin; Hand Dermatoses; Humans; Ketoconazole; Middle Aged; Onychomycosis; Recurrence

Ketoconazole is an effective treatment for chronic superficial candidiasis as well as chronic dermatophytosis. In the latter group of infections the best results were obtained in patients with tinea corporis who were not responsive to griseofulvin. It is possible to maintain some patients with chronic mucocutaneous candidiasis in remission without using prophylactic ketoconazole, although relapses may occur. However, the responses of patients with Hendersonula and Scytalidium infections as well as those with subcutaneous mycoses, such as eumycetoma, were disappointing. Patients who have an inadequate response to ketoconazole may also have subnormal serum levels of the drug and the value of such estimations in routine management needs further evaluation.

Topics: Adolescent; Adult; Antifungal Agents; Candidiasis; Candidiasis, Chronic Mucocutaneous; Dermatomycoses; Female; Griseofulvin; Humans; Imidazoles; Ketoconazole; Kinetics; Male; Microbial Sensitivity Tests; Middle Aged; Mitosporic Fungi; Mycoses; Onychomycosis; Piperazines; Tinea