grayanotoxin-i and Syncope

A 52-year-old man with Turkish background presented with nausea, emesis, one experience of syncope with loss of consciousness for a few seconds, and documented sinus bradycardia. During monitoring, several phases of bradycardia were observed. After 24 h of monitoring, the patient was free of complaints. The patient's wife reported regular consumption of pontin honey. Because of the anamnesis and the typical characteristics, grayanotoxin poisoning was diagnosed. Typical symptoms of this poisoning are hypotension, bradycardia, syncope, and loss of consciousness. When these symptoms are found and a typical anamnesis exists, this kind of intoxication has to been taken into consideration as part of the differential diagnosis.

Topics: Bradycardia; Diagnosis, Differential; Diterpenes; Dyspnea; Electrocardiography; Emigrants and Immigrants; Foodborne Diseases; Germany; Honey; Humans; Hypotension; Male; Middle Aged; Sinus Arrest, Cardiac; Syncope; Turkey

Mad honey intoxication occurs after ingestion of honey containing grayanotoxin.. We report the case of a 36-year-old man who ingested mad honey and developed atrial fibrillation.. Mad honey intoxication is often characterized by symptoms such as hypotension, bradycardia, and syncope. Patients may also experience gastrointestinal, neurologic, and cardiovascular symptoms due to intoxication. Cardiac rhythm abnormalities, including sinus bradycardia, atrioventricular blocks, and nodal rhythms, also may be observed. To our knowledge, this is the first case report of a 36-year old man developing atrial fibrillation with a slow ventricular response after mad honey ingestion.

Topics: Adult; Atrial Fibrillation; Diterpenes; Electrocardiography; Honey; Humans; Male; Syncope

Honey intoxication, a kind of food poisoning, can be seen in the Black Sea region of Turkey and in various other parts of the world as well. In this study, 66 patients were hospitalized with a variety of symptoms including nausea, vomiting, salivation, dizziness, weakness, hypotension, bradycardia and syncope several hours after the ingestion of small amounts of honey. All patients had hypotension, and majority had bradycardia. These features resolved completely in 24 h with i.v. fluids and atropine, and none died. In conclusion, honey poisoning should be taken into consideration in the differential diagnosis of acute myocardial infarction and in the patients with vomiting, hypotension and bradycardia.

Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anti-Arrhythmia Agents; Atropine; Bradycardia; Diterpenes; Female; Fluid Therapy; Honey; Humans; Hypotension; Male; Middle Aged; Plants, Toxic; Syncope

Topics: Aged; Antihypertensive Agents; Carotid Sinus; Diterpenes; Female; Humans; Male; Massage; Metoprolol; Randomized Controlled Trials as Topic; Syncope; Tilt-Table Test