gramicidin-a and Hamartoma

gramicidin-a has been researched along with Hamartoma* in 1 studies

Other Studies

1 other study(ies) available for gramicidin-a and Hamartoma

Article	Year
Bicarbonate contributes to GABAA receptor-mediated neuronal excitation in surgically resected human hypothalamic hamartomas. Epilepsy research, 2009, Volume: 83, Issue:1 The role of bicarbonate (HCO(3)(-)) in GABA(A) receptor-mediated depolarization of human hypothalamic hamartoma (HH) neurons was investigated using cellular electrophysiological and calcium imaging techniques. Activation of GABA(A) receptors with muscimol (30 microM) provoked neuronal excitation in over 70% of large (18-22 microM) HH neurons in HCO(3)(-) buffer. Subsequent perfusion of HCO(3)(-)-free HEPES buffer produced partial suppression of muscimol-induced excitation. Additionally, 53% of large HH neurons under HCO(3)(-)-free conditions exhibited reduced intracellular calcium accumulation by muscimol. These results suggest that HCO(3)(-) efflux through GABA(A) receptors on a subpopulation of large HH neurons may contribute to membrane depolarization and subsequent activation of L-type calcium channels. Topics: Adolescent; Bicarbonates; Calcium; Calcium Channels, L-Type; Child; Child, Preschool; Electrophysiology; Female; GABA Agonists; GABA-A Receptor Agonists; Gramicidin; Hamartoma; Humans; Hypothalamic Neoplasms; Infant; Male; Muscimol; Neurons; Patch-Clamp Techniques; Receptors, GABA-A; Seizures	2009

Article

Year

Bicarbonate contributes to GABAA receptor-mediated neuronal excitation in surgically resected human hypothalamic hamartomas.

Epilepsy research, 2009, Volume: 83, Issue:1

The role of bicarbonate (HCO(3)(-)) in GABA(A) receptor-mediated depolarization of human hypothalamic hamartoma (HH) neurons was investigated using cellular electrophysiological and calcium imaging techniques. Activation of GABA(A) receptors with muscimol (30 microM) provoked neuronal excitation in over 70% of large (18-22 microM) HH neurons in HCO(3)(-) buffer. Subsequent perfusion of HCO(3)(-)-free HEPES buffer produced partial suppression of muscimol-induced excitation. Additionally, 53% of large HH neurons under HCO(3)(-)-free conditions exhibited reduced intracellular calcium accumulation by muscimol. These results suggest that HCO(3)(-) efflux through GABA(A) receptors on a subpopulation of large HH neurons may contribute to membrane depolarization and subsequent activation of L-type calcium channels.

Topics: Adolescent; Bicarbonates; Calcium; Calcium Channels, L-Type; Child; Child, Preschool; Electrophysiology; Female; GABA Agonists; GABA-A Receptor Agonists; Gramicidin; Hamartoma; Humans; Hypothalamic Neoplasms; Infant; Male; Muscimol; Neurons; Patch-Clamp Techniques; Receptors, GABA-A; Seizures

2009