gramicidin-a and Dermatitis--Contact

Topics: Chemistry, Pharmaceutical; Dermatitis, Contact; Drug Combinations; Ethylenediamines; Gramicidin; Humans; Neomycin; Nystatin; Therapeutic Equivalency; Triamcinolone Acetonide

Generic Myco-Triacet II Cream would seem to be analogous to Mycolog II Cream. However, Myco-Triacet II Cream still contains the common and potent sensitizer, ethylenediamine hydrochloride, which is no longer present in Mycolog II Cream. This is another instance in which a rose by an other name does not smell as sweet.

Topics: Adult; Candidiasis; Dermatitis, Contact; Drug Combinations; Ethylenediamines; Excipients; Gramicidin; Humans; Male; Neomycin; Nystatin; Patch Tests; Therapeutic Equivalency; Triamcinolone Acetonide

Topics: Dermatitis, Contact; Drug Combinations; Ethylenediamines; Gramicidin; Humans; Neomycin; Nystatin; Pharmaceutic Aids; Triamcinolone Acetonide

Sensitivity to alpha-amylcinnamic aldehyde (alpha-AcAld) is apparently uncommon, but, like allergy to alpha-amylcinnamic alcohol (alpha-AcAlc), it often accompanies allergy to the perfume in Mycolog cream. Although alpha-AcAlc is a known ingredient, alpha-AcAld is not. However, gas-liquid chromatographic analysis shows alpha-AcAld to be present. Of fourteen persons sensitive to either chemical, ten reacted to both. Of these, one man and three women were markedly sensitive, and all three women had chronic recalcitrant vulvar eczema. That condition might have been the cause as well as the result of sensitization, but reexposure to a suspected product reproduced the eruption in both persons tested. Its use with other potent sensitizers, e.g., ethylenediamine, to treat irritations and chronic eczemas in an area of high absorption may partly explain development of allergy to a relatively weak sensitizer.

Topics: Alcohols; Aldehydes; Dermatitis, Contact; Drug Combinations; Female; Gramicidin; Humans; Male; Neomycin; Nystatin; Patch Tests; Perfume; Triamcinolone Acetonide

Topics: Dermatitis, Contact; Drug Combinations; Ethylenediamines; Female; Gramicidin; Humans; Middle Aged; Neomycin; Nystatin; Perfume; Triamcinolone Acetonide

Mycolog contact allergy is due primarily to its ethylenediamine and fragrance components. In the evaluation of Mycolog-sensitive patients, the major constituents, including the perfume at 5% or 10% in petrolatum, should be tested.

Topics: Dermatitis, Atopic; Dermatitis, Contact; Dermatologic Agents; Drug Combinations; Ethylenediamines; Gramicidin; Humans; Neomycin; Nystatin; Patch Tests; Perfume; Triamcinolone Acetonide

Topics: Dermatitis, Contact; Gramicidin; Humans; Male; Middle Aged; Neomycin; Nystatin; Ointment Bases; Perfume; Pharmaceutic Aids; Skin Tests; Triamcinolone Acetonide

Sensitivity to ethylenediamine and to epoxy resin hardeners was found in three patients with long standing contact dermatitis. In one patient, a young man, the sensitivity was elicited by occupational contact with epoxy resin hardeners and subsequently sustained by use of Mycolog cream. In two patients, both elderly women, the condition was only due to use of Mycolog cream. These case histories and test results indicate that use of Mycolog cream can result in occupational disease viz. contact dermatitis from epoxy hardeners.

Topics: Adult; Aged; Dermatitis, Contact; Dermatitis, Occupational; Drug Combinations; Drug Eruptions; Epoxy Resins; Ethylenediamines; Gramicidin; Humans; Male; Neomycin; Nystatin; Ointments; Triamcinolone Acetonide