gramicidin-a and Acute-Disease

Acute otitis externa is a common clinical condition accounting for a large proportion of patients attending the otolaryngology department, although milder cases are often managed in primary care. Treatment of the most severe forms of otitis externa involves aural toilet, followed by the application of a topical preparation, commonly in the form of an ear canal dressing. A prospective single-blind randomized controlled trial was performed to compare the efficacy of 10% glycerine-ichthammol (GI) solution and Triadcortyl (TAC) ointment, both applied as ear canal dressings, in the initial management of severe acute otitis externa. A total of 64 patients were studied. Both treatment modalities were proven efficacious in the treatment of severe acute otitis externa. Although there was a statistically significant improvement of pain parameters in the TAC group, we found no significant differences in clinical findings between the two groups. Therefore, it is recommended that GI dressing can be used instead of an antibiotic dressing as an initial treatment of severe acute otitis externa on the basis of cost, avoidance of resistance and toxicity.

Topics: Acute Disease; Adolescent; Adult; Aged; Anti-Inflammatory Agents; Drug Combinations; Female; Glycerol; Gramicidin; Humans; Male; Middle Aged; Neomycin; Nystatin; Otitis Externa; Pain Measurement; Quaternary Ammonium Compounds; Solvents; Treatment Outcome; Triamcinolone Acetonide

Topics: Acute Disease; Adolescent; Adult; Aged; Chronic Disease; Drug Combinations; Female; Gramicidin; Humans; Hypersensitivity; Male; Middle Aged; Neomycin; Nystatin; Ointments; Skin Diseases; Triamcinolone Acetonide