gr 89696 has been researched along with Brain Ischemia in 2 studies
GR 89696: a potent & selective kappa opioid receptor agonist; RN given refers to (E)-2-butenedioate(1:1); RN for parent cpd not available 11/92; GR 103545 is the (R)-isomer
Brain Ischemia: Localized reduction of blood flow to brain tissue due to arterial obstruction or systemic hypoperfusion. This frequently occurs in conjunction with brain hypoxia (HYPOXIA, BRAIN). Prolonged ischemia is associated with BRAIN INFARCTION.
| Excerpt | Relevance | Reference |
|---|---|---|
| " In these experiments GR89696 was dosed 5 min, 4, 8, 12, 16, 20 and 24 h after occlusion on the first day and then three times daily for the next three days." | 1.28 | Neuroprotective actions of GR89696, a highly potent and selective kappa-opioid receptor agonist. ( Birch, PJ; Hayes, AG; Hayward, NJ; Judd, DB; Naylor, A; Rogers, H; Scopes, DI; Tyers, MB, 1991) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (100.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Barber, A | 1 |
| Bender, HM | 1 |
| Gottschlich, R | 1 |
| Greiner, HE | 1 |
| Harting, J | 1 |
| Mauler, F | 1 |
| Seyfried, CA | 1 |
| Birch, PJ | 1 |
| Rogers, H | 1 |
| Hayes, AG | 1 |
| Hayward, NJ | 1 |
| Tyers, MB | 1 |
| Scopes, DI | 1 |
| Naylor, A | 1 |
| Judd, DB | 1 |
2 other studies available for gr 89696 and Brain Ischemia
| Article | Year |
|---|---|
Effects of GR-89696 and the novel peripherally selective OP2 agonists, EMD-61569 and EMD-61747, against focal cerebral ischemia in the rat.
Topics: Animals; Binding, Competitive; Brain Edema; Brain Ischemia; Cerebral Arteries; Levodopa; Ligation; M | 1999 |
Neuroprotective actions of GR89696, a highly potent and selective kappa-opioid receptor agonist.
Topics: Animals; Brain Ischemia; Carotid Artery Diseases; Dizocilpine Maleate; Dose-Response Relationship, D | 1991 |