gq1b-ganglioside and Virus-Diseases

Topics: Acute Disease; Adult; Autoantibodies; Autonomic Nervous System Diseases; Blepharoptosis; Bradycardia; Cranial Nerve Diseases; Cranial Nerves; Diplopia; Disease Progression; Early Diagnosis; Gangliosides; Humans; Immunoglobulins, Intravenous; Male; Miller Fisher Syndrome; Oculomotor Nerve Diseases; Ophthalmoplegia; Respiratory Tract Infections; Treatment Outcome; Vagus Nerve Diseases; Virus Diseases

Anti-GQ1b antibodies were assayed by an enzyme-linked immunosorbent assay in sera from patients with non-neurological disorders (N = 20), and with various neurological disorders (N = 59), including nine cases of Miller Fisher syndrome, 16 cases of Guillain-Barré syndrome and one case of acute post-infectious ophthalmoparesis. Such antibodies were found in most cases (8 out of 9) of Miller Fisher syndrome, and at very high titres, in one case of Guillain-Barré syndrome characterised by an initial ophthalmoparesis, and in the case of isolated post-infectious ophthalmoparesis. The latter was characterised by a long-lasting occurrence of these antibodies. Anti-GQ1b antibodies are specific for an immune-mediated neuropathy of the cranial, especially oculomotor, nerves.

Topics: Autoantibodies; Autoantigens; Autoimmune Diseases; Campylobacter Infections; Campylobacter jejuni; Enzyme-Linked Immunosorbent Assay; Female; Gangliosides; Humans; Immunoglobulin G; Immunoglobulin M; Male; Middle Aged; Miller Fisher Syndrome; Nervous System Diseases; Ophthalmoplegia; Polyradiculoneuropathy; Virus Diseases