gq1b-ganglioside and Remission--Spontaneous

The Miller Fisher syndrome, Guillain-Barre syndrome and Bickerstaff's brainstem encephalitis are related conditions in which anti-GQ1b antibody positivity occur in varied frequencies. This report demonstrates the presence of corticobulbar and corticospinal dysfunction in BBE, by means of a novel transcranial magnetic stimulation technique. It further supports the presence of protean manifestations in anti-GQ1b IgG antibody-positive spectrum of disorders.

Topics: Adult; Autoantibodies; Brain Stem; Dysarthria; Encephalitis; Evoked Potentials, Motor; Gangliosides; Guillain-Barre Syndrome; Humans; Hypoglossal Nerve; Hypoglossal Nerve Diseases; Male; Motor Neurons; Neural Conduction; Neurologic Examination; Pyramidal Tracts; Reaction Time; Reflex, Abnormal; Remission, Spontaneous; Syndrome; Tongue; Transcranial Magnetic Stimulation

To describe two cases with bilateral abducens nerve paresis associated with serum anti-GQ1b IgG antibody.. Case reports.. Two boys, aged 12 and 10 years, experienced acute onset of diplopia after preceding symptoms and signs of infection. In both boys, examination showed only bilateral abducens nerve paresis. Although routine laboratory data and magnetic resonance imaging demonstrated no pathologic findings, titer of anti-GQ1b IgG antibody in the sera of both patients was increased. Diplopia and signs of bilateral abducens nerve paresis disappeared in 6 weeks without any specific treatment.. The anti-GQ1b IgG antibody in the sera of both patients probably contributed to the bilateral abducens nerve paresis.

Topics: Abducens Nerve Diseases; Antibodies; Child; Diplopia; Eye Movements; Gangliosides; Humans; Immunoglobulin G; Infections; Male; Remission, Spontaneous