gq1b-ganglioside and Purpura--Thrombocytopenic--Idiopathic

Although acute inflammatory polyneuropathy (AIP) and immune thrombocytopenic purpura (ITP) are both believed to be immune-mediated disorders, only a few cases have been reported in which these two diseases co-existed. We describe a case of a 67-year-old patient who developed quadriparesis, ophthalmoplegia and severe sensory impairment along with thrombocytopenia. Detailed examinations, including the measurement of anti-ganglioside antibodies and anti-glycoprotein-IIb-IIIa-IgG-producing B-cells, revealed that he developed AIP and ITP. By reviewing past similar reports, we noticed that AIP associated with ITP tends to manifest severe sensory impairment and is often preceded by upper respiratory tract infection, but not by gastrointestinal infection.

Topics: Acute Disease; Aged; Autoantibodies; Gangliosides; Glucocorticoids; Guillain-Barre Syndrome; Humans; Immunoglobulins, Intravenous; Male; Pharyngitis; Platelet Count; Prednisone; Purpura, Thrombocytopenic, Idiopathic