gq1b-ganglioside and Neuromuscular-Junction-Diseases

Miller Fisher syndrome is defined by a triad of symptoms, namely areflexia, ataxia, and ophthalmoparesis. The ophthalmoparesis is mostly severe, undulating weakness of eye movements with ptosis and increased fatigability resembling a neuromuscular transmission disorder. We present a 52-year-old man with severe Miller Fisher syndrome with a high level of anti-GQ1b antibodies and a presynaptic type of neuromuscular transmission disorder. The diagnosis was confirmed by stimulated single-fiber electromyography with the use of a concentric needle electrode and various stimulation rates.

Topics: Ataxia; Autoantibodies; Diplopia; Electromyography; Evoked Potentials, Somatosensory; Gangliosides; Humans; Male; Middle Aged; Miller Fisher Syndrome; Neuromuscular Junction Diseases; Ophthalmoplegia; Reflex, Abnormal

Topics: Autoantibodies; Blepharoptosis; Diagnosis, Differential; Electromyography; Gangliosides; Humans; Immunoglobulins, Intravenous; Male; Middle Aged; Miller Fisher Syndrome; Motor Neurons; Neuromuscular Junction; Neuromuscular Junction Diseases; Oculomotor Muscles; Ophthalmoplegia; Peripheral Nerves; Predictive Value of Tests; Reflex, Abnormal