gq1b-ganglioside and Lambert-Eaton-Myasthenic-Syndrome

Autoantibodies to acetylcholine receptors and to voltage-gated calcium and potassium channels are thought to be pathogenic in three peripheral neurological disorders: myasthenia gravis, the Lambert Eaton syndrome and acquired neuromyotonia. However, evidence for the role of antibodies in conditions involving the central nervous system, is scanty or unclear. This review describes the ways in which the roles of autoantibodies have been defined in the peripheral diseases, and discusses the more controversial evidence for involvement of autoantibodies in some central disorders such as multiple sclerosis.

Topics: Autoantibodies; Calcium Channels; Cell Line; Gangliosides; Humans; Isaacs Syndrome; Lambert-Eaton Myasthenic Syndrome; Myasthenia Gravis; Nervous System Diseases; Neurons; Receptors, Cholinergic

Topics: Action Potentials; Aged; Asymptomatic Diseases; Ataxia; Autoantibodies; Blepharoptosis; Calcium Channels, P-Type; Calcium Channels, Q-Type; Diplopia; Electrodiagnosis; Electromyography; Female; Gangliosides; Humans; Hypesthesia; Lambert-Eaton Myasthenic Syndrome; Median Nerve; Miller Fisher Syndrome; Muscle Weakness; Mydriasis; Neural Conduction; Oculomotor Muscles; Tibial Nerve; Ulnar Nerve

Topics: Autoantibodies; Female; Gangliosides; Guillain-Barre Syndrome; Humans; Lambert-Eaton Myasthenic Syndrome; Middle Aged; Neuromuscular Junction; Presynaptic Terminals