gq1b-ganglioside and Central-Nervous-System-Diseases

We report a case of Fisher syndrome accompanied by ocular flutter. A 19-year-old man presented with diplopia and vertigo, associated with preceding symptoms of common cold. Since symmetric weakness of abduction in both eyes, truncal ataxia, diminution of tendon reflexes, and gaze nystagmus were noted, he was diagnosed as having Fisher syndrome. Ocular flutter also was noticed during horizontal gaze. Serum anti-GQ1b antibody and anti-GM1 antibody were detected. He was followed without therapy and the symptoms resolved. The accompanying ocular flutter may suggest that a central nervous system disorder may also be present in Fisher syndrome.

Topics: Autoantibodies; Biomarkers; Central Nervous System Diseases; G(M1) Ganglioside; Gangliosides; Humans; Male; Miller Fisher Syndrome; Ocular Motility Disorders; Peripheral Nervous System Diseases; Young Adult