gossypol has been researched along with Sterility, Male in 23 studies
Gossypol: A dimeric sesquiterpene found in cottonseed (GOSSYPIUM). The (-) isomer is active as a male contraceptive (CONTRACEPTIVE AGENTS, MALE) whereas toxic symptoms are associated with the (+) isomer.
| Excerpt | Relevance | Reference |
|---|---|---|
| "This study was aimed at evaluating the efficacy of berberine-rich fraction (BF) as a protective and/or a therapeutic agent against inflammation and oxidative stress during male infertility." | 7.88 | The Ameliorating Effect of Berberine-Rich Fraction against Gossypol-Induced Testicular Inflammation and Oxidative Stress. ( Attia, R; Ghareeb, DA; Saleh, SR, 2018) |
| "To ascertain whether the side effects of gossypol, hypokalemia and irreversibility, could be avoided on dose reduction." | 5.09 | Low dose gossypol for male contraception. ( Cao, L; Chen, ZX; Gu, ZP; Mao, BY; Segal, SJ; Tan, YZ; Wang, YX; You, GD; Zhang, RA, 2000) |
| "This study was aimed at evaluating the efficacy of berberine-rich fraction (BF) as a protective and/or a therapeutic agent against inflammation and oxidative stress during male infertility." | 3.88 | The Ameliorating Effect of Berberine-Rich Fraction against Gossypol-Induced Testicular Inflammation and Oxidative Stress. ( Attia, R; Ghareeb, DA; Saleh, SR, 2018) |
| " Results showed that the dosage regimen could damage the epididymal sperms and onset of antifertility within 6 weeks in male rats, and prevent the incidence of the side effect of irreversible azoospermia." | 2.41 | [A beam of dawn light of study on gossypol as a safe, effective, and reversible male antifertility contraceptive--evaluation of the studies by using low dose gossypol combined with steroid hormone for male contraception]. ( Xue, S, 2000) |
| "Gossypol is a polyphenol isolated from the seed, roots, and stem of the cotton plant (Gossypium sp." | 2.41 | Gossypol: a contraceptive for men. ( Coutinho, EM, 2002) |
| " Experiments conducted on Sprague-Dawley rats and cynomolgous monkeys confirm that either (-) or (+) gossypol is too toxic to be developed for human contraception." | 2.40 | Gossypol: reasons for its failure to be accepted as a safe, reversible male antifertility drug. ( Griffin, PD; Waites, GM; Wang, C, 1998) |
| "Male infertility is a significant health problem for which few aetiological factors have been identified." | 2.37 | Occupation-related male infertility: a review. ( Baker, HW; Hanna, PJ; Henderson, J, 1986) |
| " In conclusion, free gossypol in diet induced adverse effects on semen quality in rams, but selenium supplementation successfully counteracts most of the hazardous effects of gossypol on semen characteristics." | 1.38 | Alleviation of reproductive toxicity of gossypol using selenium supplementation in rams. ( El-Mokadem, MY; Samak, MA; Taha, TA; Yassen, AM, 2012) |
| "(+)-Gossypol has neither antifertility effect nor toxicity at the dosage of 30 mg/kg orally for 14 days in male rats, but slight damage was found in the germinal epithelium of the testis in animals dosed for 4 weeks." | 1.27 | Effect of (-)- and (+)-gossypol on fertility in male rats. ( Guan, MH; Lei, HP; Wang, NG; Zhou, LF, 1987) |
| "Gossypol proved to be a powerful inhibitor of the six enzymes studied." | 1.27 | In vitro inhibition by gossypol of oxidoreductases from human tissues. ( Blanco, A; Burgos, C; Gerez de Burgos, NM; Rovai, LE, 1986) |
| "Gossypol was isolated and purified from cotton seed flour." | 1.26 | Inhibition of rat testis LDH-X activity by gossypol. ( Bamji, MS; Giridharan, N; Sankaram, AV, 1982) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 11 (47.83) | 18.7374 |
| 1990's | 3 (13.04) | 18.2507 |
| 2000's | 5 (21.74) | 29.6817 |
| 2010's | 3 (13.04) | 24.3611 |
| 2020's | 1 (4.35) | 2.80 |
| Authors | Studies |
|---|---|
| Shepherd, A | 1 |
| Brunckhorst, O | 1 |
| Ahmed, K | 1 |
| Xu, Q | 1 |
| Saleh, SR | 1 |
| Attia, R | 1 |
| Ghareeb, DA | 1 |
| Roychoudhury, S | 1 |
| Massanyi, P | 1 |
| Slamecka, J | 1 |
| Chlebec, I | 1 |
| Trandzik, J | 1 |
| Bulla, J | 1 |
| Okab, AB | 1 |
| Taha, TA | 2 |
| Salem, MH | 1 |
| Ayoub, MA | 1 |
| El-Sharaky, AS | 1 |
| Newairy, AA | 1 |
| Elguindy, NM | 1 |
| Elwafa, AA | 1 |
| El-Mokadem, MY | 1 |
| Samak, MA | 1 |
| Yassen, AM | 1 |
| Xue, S | 1 |
| Pösö, H | 1 |
| Wichmann, K | 1 |
| Jänne, J | 1 |
| Luukkainen, T | 1 |
| Ridley, AJ | 1 |
| Blasco, L | 1 |
| Sotelo, A | 1 |
| Montalvo, I | 1 |
| de la Luz Crail, M | 1 |
| González-Garza, MT | 1 |
| Giridharan, N | 2 |
| Bamji, MS | 2 |
| Sankaram, AV | 1 |
| Akingbemi, BT | 1 |
| Aire, TA | 1 |
| Oke, BO | 1 |
| Waites, GM | 1 |
| Wang, C | 1 |
| Griffin, PD | 1 |
| Dabrowski, K | 1 |
| Rinchard, J | 1 |
| Lee, KJ | 1 |
| Blom, JH | 1 |
| Ciereszko, A | 1 |
| Ottobre, J | 1 |
| Gu, ZP | 1 |
| Mao, BY | 1 |
| Wang, YX | 1 |
| Zhang, RA | 1 |
| Tan, YZ | 1 |
| Chen, ZX | 1 |
| Cao, L | 1 |
| You, GD | 1 |
| Segal, SJ | 1 |
| Coutinho, EM | 2 |
| Nair, IN | 1 |
| Bhiwgade, DA | 1 |
| Sun, TS | 1 |
| Melo, JF | 1 |
| Henderson, J | 1 |
| Baker, HW | 1 |
| Hanna, PJ | 1 |
| Sesikeran, B | 1 |
| Madhyastha, MN | 1 |
| Sinha Hikim, AP | 1 |
| Hoffer, AP | 1 |
| Wang, NG | 1 |
| Zhou, LF | 1 |
| Guan, MH | 1 |
| Lei, HP | 1 |
| Burgos, C | 1 |
| Gerez de Burgos, NM | 1 |
| Rovai, LE | 1 |
| Blanco, A | 1 |
5 reviews available for gossypol and Sterility, Male
| Article | Year |
|---|---|
Botanicals in health and disease of the testis and male fertility: A scoping review.
Topics: Fertility; Gossypol; Humans; Infertility, Male; Male; Testis; Testosterone | 2022 |
[A beam of dawn light of study on gossypol as a safe, effective, and reversible male antifertility contraceptive--evaluation of the studies by using low dose gossypol combined with steroid hormone for male contraception].
Topics: Animals; Contraceptive Agents, Male; Drug Interactions; Ethinyl Estradiol; Gossypol; Humans; Hypokal | 2000 |
Gossypol: reasons for its failure to be accepted as a safe, reversible male antifertility drug.
Topics: Acetates; Animals; Contraceptive Agents, Male; Gossypol; Humans; Hypokalemia; Infertility, Male; Mal | 1998 |
Gossypol: a contraceptive for men.
Topics: Animals; Antispermatogenic Agents; Contraceptive Agents, Male; Gossypol; Infertility, Male; Male; Sp | 2002 |
Occupation-related male infertility: a review.
Topics: Anesthetics; Carbon Disulfide; Fertility; Gossypol; Herbicides; Hot Temperature; Humans; Infertility | 1986 |
1 trial available for gossypol and Sterility, Male
| Article | Year |
|---|---|
Low dose gossypol for male contraception.
Topics: Contraceptive Agents, Male; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; | 2000 |
17 other studies available for gossypol and Sterility, Male
| Article | Year |
|---|---|
The Ameliorating Effect of Berberine-Rich Fraction against Gossypol-Induced Testicular Inflammation and Oxidative Stress.
Topics: Animals; Berberine; Gossypol; Infertility, Male; Inflammation; Male; Oxidative Stress; Rats; Rats, S | 2018 |
In vitro gossypol induced spermatozoa motility alterations in rabbits.
Topics: Animals; Cottonseed Oil; Gossypol; Infertility, Male; Male; Rabbits; Sperm Motility; Spermatozoa | 2009 |
Spermatotoxicity, biochemical changes and histological alteration induced by gossypol in testicular and hepatic tissues of male rats.
Topics: Animals; Antioxidants; Chemical and Drug Induced Liver Injury; Follicle Stimulating Hormone; Gossypo | 2010 |
Alleviation of reproductive toxicity of gossypol using selenium supplementation in rams.
Topics: Animal Feed; Animals; Diet; Dietary Supplements; Gossypol; Infertility, Male; Male; Selenium; Semen | 2012 |
Gossypol, a powerful inhibitor of human spermatozoal metabolism.
Topics: Contraceptive Agents, Male; Depression, Chemical; Fructose; Gossypol; Humans; Infertility, Male; Mal | 1980 |
Testosterone and gossypol effects on human sperm motility.
Topics: Bucladesine; Caffeine; Dose-Response Relationship, Drug; Gossypol; Humans; Infertility, Male; Male; | 1981 |
Infertility in male rats induced by diets containing whole cottonseed flour.
Topics: Animals; Body Weight; Cottonseed Oil; Dose-Response Relationship, Drug; Gossypol; Infertility, Male; | 1982 |
Inhibition of rat testis LDH-X activity by gossypol.
Topics: Animals; Cells, Cultured; Contraceptive Agents, Male; Culture Media; Cytosol; Enzyme Inhibitors; Fer | 1982 |
Infection with Trypanosoma brucei potentiates the antifertility effect of gossypol, especially in the protein-malnourished male rat.
Topics: Animals; Body Weight; Genitalia, Male; Gossypol; Infertility, Male; Male; Microscopy, Electron; Orga | 1996 |
Effects of diets containing gossypol on reproductive capacity of rainbow trout (Oncorhynchus mykiss).
Topics: Animal Feed; Animals; Diet; Female; Gonadal Steroid Hormones; Gossypol; Growth; Hematocrit; Hemoglob | 2000 |
Effect of gossypol on pituitary reproductive axis: ultrastructural and biochemical studies.
Topics: Administration, Oral; Animals; Contraceptive Agents, Male; Gossypol; Infertility, Male; Male; Organ | 1990 |
[Long-term follow-up studies on patients poisoned by cottonseed oil].
Topics: Adolescent; Adult; Cottonseed Oil; Female; Follow-Up Studies; Gossypol; Humans; Infertility, Male; M | 1986 |
Clinical experience with gossypol in non-Chinese men: a follow-up.
Topics: Contraceptive Agents, Male; Gonadotropin-Releasing Hormone; Gossypol; Humans; Infertility, Male; Lut | 1988 |
Dose and time related changes in LDH-X activity, epididymal carnitine levels and fertility, in gossypol-treated male rats.
Topics: Animals; Carnitine; Epididymis; Fertility; Gossypol; Infertility, Male; L-Lactate Dehydrogenase; Mal | 1987 |
Quantitative analysis of germ cells and Leydig cells in rat made infertile with gossypol.
Topics: Animals; Gossypol; Infertility, Male; Leydig Cells; Male; Rats; Spermatogenesis; Spermatozoa | 1987 |
Effect of (-)- and (+)-gossypol on fertility in male rats.
Topics: Animals; Gossypol; Infertility, Male; Male; Rats; Rats, Inbred Strains; Sperm Motility; Stereoisomer | 1987 |
In vitro inhibition by gossypol of oxidoreductases from human tissues.
Topics: Glutamate Dehydrogenase; Gossypol; Humans; Infertility, Male; Isoenzymes; L-Lactate Dehydrogenase; L | 1986 |