gossypol has been researched along with Squamous Cell Carcinoma of Head and Neck in 2 studies
Gossypol: A dimeric sesquiterpene found in cottonseed (GOSSYPIUM). The (-) isomer is active as a male contraceptive (CONTRACEPTIVE AGENTS, MALE) whereas toxic symptoms are associated with the (+) isomer.
Squamous Cell Carcinoma of Head and Neck: The most common type of head and neck carcinoma that originates from cells on the surface of the NASAL CAVITY; MOUTH; PARANASAL SINUSES, SALIVARY GLANDS, and LARYNX. Mutations in TNFRSF10B, PTEN, and ING1 genes are associated with this cancer.
| Excerpt | Relevance | Reference |
|---|---|---|
| " For the pharmacokinetic analysis, plasma AT-101 levels were measured by HPLC in blood samples collected from patients enrolled in our clinical phase I/II study." | 2.80 | Targeting anti-apoptotic Bcl-2 by AT-101 to increase radiation efficacy: data from in vitro and clinical pharmacokinetic studies in head and neck cancer. ( Dubbelman, R; Hoebers, FJ; Kuipers, GK; Lafleur, MV; Slotman, BJ; Stoter, TR; van den Brekel, MW; Verheij, M; Zerp, SF, 2015) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (50.00) | 24.3611 |
| 2020's | 1 (50.00) | 2.80 |
| Authors | Studies |
|---|---|
| Melo, G | 1 |
| Silva, CAB | 1 |
| Hague, A | 1 |
| Parkinson, EK | 1 |
| Rivero, ERC | 1 |
| Zerp, SF | 1 |
| Stoter, TR | 1 |
| Hoebers, FJ | 1 |
| van den Brekel, MW | 1 |
| Dubbelman, R | 1 |
| Kuipers, GK | 1 |
| Lafleur, MV | 1 |
| Slotman, BJ | 1 |
| Verheij, M | 1 |
1 review available for gossypol and Squamous Cell Carcinoma of Head and Neck
| Article | Year |
|---|---|
Anticancer effects of putative and validated BH3-mimetic drugs in head and neck squamous cell carcinomas: An overview of current knowledge.
Topics: Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Gossypol; Head and Neck Neoplasms; Humans; Proto | 2022 |
1 trial available for gossypol and Squamous Cell Carcinoma of Head and Neck
| Article | Year |
|---|---|
Targeting anti-apoptotic Bcl-2 by AT-101 to increase radiation efficacy: data from in vitro and clinical pharmacokinetic studies in head and neck cancer.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Blotting, Western; Carcinoma, Squamous Cell; Cell Line | 2015 |