gossypol has been researched along with Response Evaluation Criteria in Solid Tumors in 1 studies
Gossypol: A dimeric sesquiterpene found in cottonseed (GOSSYPIUM). The (-) isomer is active as a male contraceptive (CONTRACEPTIVE AGENTS, MALE) whereas toxic symptoms are associated with the (+) isomer.
Response Evaluation Criteria in Solid Tumors: An internationally recognized set of published rules used for evaluation of cancer treatment that define when tumors found in cancer patients improve, worsen, or remain stable during treatment. These criteria are based specifically on the response of the tumor(s) to treatment, and not on the overall health status of the patient resulting from treatment.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Background Adrenal cortical carcinoma (ACC) is a rare cancer with treatment options of limited efficacy, and poor prognosis if metastatic." | 2.90 | A phase II study of the orally administered negative enantiomer of gossypol (AT-101), a BH3 mimetic, in patients with advanced adrenal cortical carcinoma. ( Adjei, AA; Bible, KC; Erlichman, C; Gandara, DR; Kane, MA; Menefee, ME; Quinn, DI; Reidy-Lagunes, D; Shah, MH; Xie, H; Yin, J, 2019) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Xie, H | 1 |
| Yin, J | 1 |
| Shah, MH | 1 |
| Menefee, ME | 1 |
| Bible, KC | 1 |
| Reidy-Lagunes, D | 1 |
| Kane, MA | 1 |
| Quinn, DI | 1 |
| Gandara, DR | 1 |
| Erlichman, C | 1 |
| Adjei, AA | 1 |
1 trial available for gossypol and Response Evaluation Criteria in Solid Tumors
| Article | Year |
|---|---|
A phase II study of the orally administered negative enantiomer of gossypol (AT-101), a BH3 mimetic, in patients with advanced adrenal cortical carcinoma.
Topics: Adrenal Cortex Neoplasms; Adrenocortical Carcinoma; Adult; Aged; Antineoplastic Agents, Phytogenic; | 2019 |