gossypol has been researched along with Pulmonary Fibrosis in 4 studies
Gossypol: A dimeric sesquiterpene found in cottonseed (GOSSYPIUM). The (-) isomer is active as a male contraceptive (CONTRACEPTIVE AGENTS, MALE) whereas toxic symptoms are associated with the (+) isomer.
Pulmonary Fibrosis: A process in which normal lung tissues are progressively replaced by FIBROBLASTS and COLLAGEN causing an irreversible loss of the ability to transfer oxygen into the bloodstream via PULMONARY ALVEOLI. Patients show progressive DYSPNEA finally resulting in death.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Pulmonary fibrosis is a chronic and irreversible scarring disease in the lung with poor prognosis." | 5.48 | Prevention and treatment of bleomycin-induced pulmonary fibrosis with the lactate dehydrogenase inhibitor gossypol. ( Judge, JL; Kottmann, RM; Nagel, DJ; Owens, KM; Phipps, RP; Rackow, A; Sime, PJ, 2018) |
| "Pulmonary fibrosis is a chronic and irreversible scarring disease in the lung with poor prognosis." | 1.48 | Prevention and treatment of bleomycin-induced pulmonary fibrosis with the lactate dehydrogenase inhibitor gossypol. ( Judge, JL; Kottmann, RM; Nagel, DJ; Owens, KM; Phipps, RP; Rackow, A; Sime, PJ, 2018) |
| "Pulmonary fibrosis is a common and dose-limiting side-effect of ionizing radiation used to treat cancers of the thoracic region." | 1.42 | Ionizing radiation induces myofibroblast differentiation via lactate dehydrogenase. ( Judge, JL; Kottmann, RM; Owens, KM; Phipps, RP; Pollock, SJ; Sime, PJ; Thatcher, TH; Williams, JP; Woeller, CF, 2015) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 4 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Judge, JL | 4 |
| Lacy, SH | 1 |
| Ku, WY | 1 |
| Owens, KM | 4 |
| Hernady, E | 1 |
| Thatcher, TH | 3 |
| Williams, JP | 2 |
| Phipps, RP | 4 |
| Sime, PJ | 4 |
| Kottmann, RM | 4 |
| Nagel, DJ | 1 |
| Rackow, A | 1 |
| Pollock, SJ | 1 |
| Woeller, CF | 1 |
| Trawick, E | 1 |
| Wahl, LA | 1 |
| Epa, AP | 1 |
4 other studies available for gossypol and Pulmonary Fibrosis
| Article | Year |
|---|---|
The Lactate Dehydrogenase Inhibitor Gossypol Inhibits Radiation-Induced Pulmonary Fibrosis.
Topics: Animals; Cytokines; Dose-Response Relationship, Drug; Gossypol; L-Lactate Dehydrogenase; Male; Mice; | 2017 |
Prevention and treatment of bleomycin-induced pulmonary fibrosis with the lactate dehydrogenase inhibitor gossypol.
Topics: Animals; Antibiotics, Antineoplastic; Bleomycin; Cell Differentiation; Cells, Cultured; Contraceptiv | 2018 |
Ionizing radiation induces myofibroblast differentiation via lactate dehydrogenase.
Topics: Animals; Cell Differentiation; Cells, Cultured; Enzyme Inhibitors; Gossypol; Humans; Isoenzymes; L-L | 2015 |
Pharmacologic inhibition of lactate production prevents myofibroblast differentiation.
Topics: Animals; Cell Differentiation; Cell Line; Enzyme Inhibitors; Extracellular Matrix; Gene Knockdown Te | 2015 |