gossypol has been researched along with Ovarian Neoplasms in 9 studies
Gossypol: A dimeric sesquiterpene found in cottonseed (GOSSYPIUM). The (-) isomer is active as a male contraceptive (CONTRACEPTIVE AGENTS, MALE) whereas toxic symptoms are associated with the (+) isomer.
Ovarian Neoplasms: Tumors or cancer of the OVARY. These neoplasms can be benign or malignant. They are classified according to the tissue of origin, such as the surface EPITHELIUM, the stromal endocrine cells, and the totipotent GERM CELLS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Effects of the gossypol on endometriosis in 12 cases of control were observed." | 7.67 | [Clinical effects and experimental study on gossypol in endometriosis]. ( Wang, M; Xu, LF; Zhao, CL, 1989) |
| "Effects of the gossypol on endometriosis in 12 cases of control were observed." | 3.67 | [Clinical effects and experimental study on gossypol in endometriosis]. ( Wang, M; Xu, LF; Zhao, CL, 1989) |
| "Upon gossypol treatment, changes in phosphorylation of twenty-nine proteins including YAP1 and AKAP12 were characterized." | 1.40 | Phosphoproteomic analysis of gossypol-induced apoptosis in ovarian cancer cell line, HOC1a. ( Chen, Y; Deng, H; Ge, R; Jin, L; Lian, Q; Mu, X, 2014) |
| "Gossypol treatment resulted in cell death through oxidative stress." | 1.39 | Gossypol induces apoptosis in ovarian cancer cells through oxidative stress. ( Chen, Y; Deng, H; Ge, R; Jin, L; Li, X; Lian, Q; Wang, J, 2013) |
| "Current treatment strategies for ovarian cancer focus on novel drug combinations of cytotoxic agents and molecular targeted agents or novel drug delivery strategies that often involve intraperitoneal (IP) injection." | 1.39 | Poly(ethylene glycol)-block-poly(ε-caprolactone) micelles for combination drug delivery: evaluation of paclitaxel, cyclopamine and gossypol in intraperitoneal xenograft models of ovarian cancer. ( Cho, H; Kwon, GS; Lai, TC, 2013) |
| "Chemoresistance of ovarian cancer has been previously attributed to the expression and activation of Bcl-2 family proteins." | 1.38 | Proapoptotic protein Smac mediates apoptosis in cisplatin-resistant ovarian cancer cells when treated with the anti-tumor agent AT101. ( Hu, W; Liu, X; Nie, C; Tang, J; Wang, F; Wei, Y; Yuan, Z, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (11.11) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (11.11) | 29.6817 |
| 2010's | 6 (66.67) | 24.3611 |
| 2020's | 1 (11.11) | 2.80 |
| Authors | Studies |
|---|---|
| Li, C | 1 |
| Song, Y | 1 |
| Li, P | 1 |
| Wang, J | 1 |
| Jin, L | 2 |
| Li, X | 1 |
| Deng, H | 3 |
| Chen, Y | 2 |
| Lian, Q | 2 |
| Ge, R | 2 |
| Cho, H | 2 |
| Cho, CS | 1 |
| Indig, GL | 1 |
| Lavasanifar, A | 1 |
| Vakili, MR | 1 |
| Kwon, GS | 2 |
| Mu, X | 1 |
| Atmaca, H | 2 |
| Gorumlu, G | 1 |
| Karaca, B | 2 |
| Degirmenci, M | 1 |
| Tunali, D | 1 |
| Cirak, Y | 1 |
| Purcu, DU | 1 |
| Uzunoglu, S | 2 |
| Karabulut, B | 2 |
| Sanli, UA | 2 |
| Uslu, R | 2 |
| Hu, W | 1 |
| Wang, F | 1 |
| Tang, J | 1 |
| Liu, X | 1 |
| Yuan, Z | 1 |
| Nie, C | 1 |
| Wei, Y | 1 |
| Lai, TC | 1 |
| Bozkurt, E | 1 |
| Kisim, A | 1 |
| Sezgin, C | 1 |
| Xu, LF | 1 |
| Wang, M | 1 |
| Zhao, CL | 1 |
9 other studies available for gossypol and Ovarian Neoplasms
| Article | Year |
|---|---|
MCL1 regulates cell death, tumor growth and chemosensitivity to sabutoclax in ovarian adenocarcinoma.
Topics: Adenocarcinoma; Animals; Cell Death; Cell Line, Tumor; Cell Proliferation; Drug Resistance, Neoplasm | 2020 |
Gossypol induces apoptosis in ovarian cancer cells through oxidative stress.
Topics: Apoptosis; Aspartic Acid; Carrier Proteins; Cell Line, Tumor; Chaperonin 60; Contraceptive Agents, M | 2013 |
Polymeric micelles for apoptosis-targeted optical imaging of cancer and intraoperative surgical guidance.
Topics: Animals; Antineoplastic Agents; Apoptosis; Female; Fluorescent Dyes; Gossypol; Humans; In Situ Nick- | 2014 |
Phosphoproteomic analysis of gossypol-induced apoptosis in ovarian cancer cell line, HOC1a.
Topics: Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Female; Gossypol; Humans; Neoplasm Proteins; Ova | 2014 |
Combined gossypol and zoledronic acid treatment results in synergistic induction of cell death and regulates angiogenic molecules in ovarian cancer cells.
Topics: Angiogenesis Inducing Agents; Caspase 3; Caspase 7; Cell Death; Cell Line, Tumor; Cell Proliferation | 2009 |
Proapoptotic protein Smac mediates apoptosis in cisplatin-resistant ovarian cancer cells when treated with the anti-tumor agent AT101.
Topics: Antineoplastic Agents; Apoptosis; Apoptosis Regulatory Proteins; bcl-2-Associated X Protein; Caspase | 2012 |
Poly(ethylene glycol)-block-poly(ε-caprolactone) micelles for combination drug delivery: evaluation of paclitaxel, cyclopamine and gossypol in intraperitoneal xenograft models of ovarian cancer.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Line, Tumor; Cell Survival; Drug Carri | 2013 |
Combination of AT-101/cisplatin overcomes chemoresistance by inducing apoptosis and modulating epigenetics in human ovarian cancer cells.
Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Caspase 3; Caspase 7; Cell Line, Tumor; C | 2013 |
[Clinical effects and experimental study on gossypol in endometriosis].
Topics: Adult; Antineoplastic Agents, Phytogenic; Drugs, Chinese Herbal; Endometriosis; Female; Gossypol; Hu | 1989 |