gossypol has been researched along with Metastase in 4 studies
Gossypol: A dimeric sesquiterpene found in cottonseed (GOSSYPIUM). The (-) isomer is active as a male contraceptive (CONTRACEPTIVE AGENTS, MALE) whereas toxic symptoms are associated with the (+) isomer.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The association of cycle 1 neutropenia with overall survival (OS) was examined post hoc in a randomized phase II trial of 221 men with mCRPC who received docetaxel-prednisone combined with placebo or AT-101 (bcl-2 inhibitor); weekly blood cell counts were performed during the first cycle." | 5.16 | Neutropenia as a potential pharmacodynamic marker for docetaxel-based chemotherapy in men with metastatic castration-resistant prostate cancer. ( Berry, WR; Galsky, MD; Leopold, L; Pond, GR; Sonpavde, G; Wood, BA, 2012) |
| "Gossypol is a natural polyphenolic compound with anti-inflammation, anti-oxidant, and anticancer activities." | 1.62 | Gossypol Reduces Metastasis and Epithelial-Mesenchymal Transition by Targeting Protease in Human Cervical Cancer. ( Chen, PN; Chu, SC; Hsieh, YS; Huang, SC; Kao, SH; Lin, MS, 2021) |
| "Gossypol was sufficient to reduce the invasion, migration and adhesion in DLD-1 and COLO 205 cells." | 1.51 | Antimetastatic effects of gossypol on colon cancer cells by targeting the u-PA and FAK pathways. ( Chen, PN; Chu, SC; Hsieh, YS; Hsu, LS; Huang, SF; Tu, YC, 2019) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 3 (75.00) | 24.3611 |
| 2020's | 1 (25.00) | 2.80 |
| Authors | Studies |
|---|---|
| Huang, SF | 1 |
| Chu, SC | 2 |
| Hsu, LS | 1 |
| Tu, YC | 1 |
| Chen, PN | 2 |
| Hsieh, YS | 2 |
| Huang, SC | 1 |
| Kao, SH | 1 |
| Lin, MS | 1 |
| Pond, GR | 2 |
| Armstrong, AJ | 1 |
| Galsky, MD | 2 |
| Wood, BA | 2 |
| Leopold, L | 2 |
| Sonpavde, G | 2 |
| Berry, WR | 1 |
2 trials available for gossypol and Metastase
| Article | Year |
|---|---|
Efficacy of docetaxel-based chemotherapy following ketoconazole in metastatic castration-resistant prostate cancer: implications for prior therapy in clinical trials.
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Disease-Free Survival; Docetaxel; Gossypol; Hu | 2013 |
Neutropenia as a potential pharmacodynamic marker for docetaxel-based chemotherapy in men with metastatic castration-resistant prostate cancer.
Topics: Antineoplastic Combined Chemotherapy Protocols; Disease-Free Survival; Docetaxel; Gossypol; Humans; | 2012 |
2 other studies available for gossypol and Metastase
| Article | Year |
|---|---|
Antimetastatic effects of gossypol on colon cancer cells by targeting the u-PA and FAK pathways.
Topics: Animals; Cadherins; Cell Line, Tumor; Cell Movement; Cell Survival; Colonic Neoplasms; Epithelial-Me | 2019 |
Gossypol Reduces Metastasis and Epithelial-Mesenchymal Transition by Targeting Protease in Human Cervical Cancer.
Topics: Animals; Antineoplastic Agents, Phytogenic; Cell Movement; Disease Models, Animal; Epithelial-Mesenc | 2021 |