Page last updated: 2024-10-28

gossypol and Melanoma

gossypol has been researched along with Melanoma in 10 studies

Gossypol: A dimeric sesquiterpene found in cottonseed (GOSSYPIUM). The (-) isomer is active as a male contraceptive (CONTRACEPTIVE AGENTS, MALE) whereas toxic symptoms are associated with the (+) isomer.

Melanoma: A malignant neoplasm derived from cells that are capable of forming melanin, which may occur in the skin of any part of the body, in the eye, or, rarely, in the mucous membranes of the genitalia, anus, oral cavity, or other sites. It occurs mostly in adults and may originate de novo or from a pigmented nevus or malignant lentigo. Melanomas frequently metastasize widely, and the regional lymph nodes, liver, lungs, and brain are likely to be involved. The incidence of malignant skin melanomas is rising rapidly in all parts of the world. (Stedman, 25th ed; from Rook et al., Textbook of Dermatology, 4th ed, p2445)

Research Excerpts

ExcerptRelevanceReference
"The aim of the present study was to identify the potential therapeutic effects of BH3-mimetic gossypol on melanoma cells with acquired resistance to BRAF inhibitors."7.80BH3-mimetic gossypol-induced autophagic cell death in mutant BRAF melanoma cells with high expression of p21Cip¹.). ( Jang, GH; Lee, M, 2014)
"The cytotoxicity of the (-)- and (+)-isomers and the quinone metabolite gossypolone prepared from the naturally occurring polyphenolic dialdehyde gossypol were compared using two human melanoma cell lines (SK-mel-19 and SK-mel-28) with a similar growth rate, one melanotic (melanin content of 69 pg/cell) and one amelanotic (melanin content of 10 pg/cell)."7.69Cytotoxicity of gossypol enantiomers and its quinone metabolite gossypolone in melanoma cell lines. ( Blackstaffe, L; Fish, RG; Shelley, MD, 1997)
"The aim of the present study was to identify the potential therapeutic effects of BH3-mimetic gossypol on melanoma cells with acquired resistance to BRAF inhibitors."3.80BH3-mimetic gossypol-induced autophagic cell death in mutant BRAF melanoma cells with high expression of p21Cip¹.). ( Jang, GH; Lee, M, 2014)
"The cytotoxicity of the (-)- and (+)-isomers and the quinone metabolite gossypolone prepared from the naturally occurring polyphenolic dialdehyde gossypol were compared using two human melanoma cell lines (SK-mel-19 and SK-mel-28) with a similar growth rate, one melanotic (melanin content of 69 pg/cell) and one amelanotic (melanin content of 10 pg/cell)."3.69Cytotoxicity of gossypol enantiomers and its quinone metabolite gossypolone in melanoma cell lines. ( Blackstaffe, L; Fish, RG; Shelley, MD, 1997)
"Malignant melanoma has shown increased incidence and high mortality rate in the last three decades."1.48Combination therapy with BH3 mimetic and hyperthermia tends to be more effective on anti-melanoma treatment. ( Guo, F; Lan, B; Li, X; Peng, B; Shi, Z; Wang, X; Zhang, G, 2018)
"Cutaneous malignant melanoma is among the deadliest human cancers, broadly resistant to most clinical therapies."1.43Integrated Genomics Identifies miR-32/MCL-1 Pathway as a Critical Driver of Melanomagenesis: Implications for miR-Replacement and Combination Therapy. ( Merlino, G; Mishra, PJ, 2016)

Research

Studies (10)

TimeframeStudies, this research(%)All Research%
pre-19903 (30.00)18.7374
1990's1 (10.00)18.2507
2000's1 (10.00)29.6817
2010's4 (40.00)24.3611
2020's1 (10.00)2.80

Authors

AuthorsStudies
Nguyen, M1
Marcellus, RC1
Roulston, A1
Watson, M1
Serfass, L1
Murthy Madiraju, SR1
Goulet, D1
Viallet, J1
Bélec, L1
Billot, X1
Acoca, S1
Purisima, E1
Wiegmans, A1
Cluse, L1
Johnstone, RW1
Beauparlant, P1
Shore, GC1
Haasler, L1
Kondadi, AK1
Tsigaras, T1
von Montfort, C1
Graf, P1
Stahl, W1
Brenneisen, P1
Shi, Z1
Lan, B1
Peng, B1
Wang, X1
Zhang, G1
Li, X1
Guo, F1
Jang, GH1
Lee, M1
Liu, Y1
Xie, M1
Song, T1
Sheng, H1
Yu, X1
Zhang, Z1
Mishra, PJ2
Merlino, G1
VERMEL, EM2
KRUGLIAK, SA1
Tuszynski, GP1
Cossu, G1
Blackstaffe, L1
Shelley, MD1
Fish, RG1

Other Studies

10 other studies available for gossypol and Melanoma

ArticleYear
Small molecule obatoclax (GX15-070) antagonizes MCL-1 and overcomes MCL-1-mediated resistance to apoptosis.
    Proceedings of the National Academy of Sciences of the United States of America, 2007, Dec-04, Volume: 104, Issue:49

    Topics: Animals; Antineoplastic Agents; Apoptosis; bcl-2 Homologous Antagonist-Killer Protein; Boronic Acids

2007
The BH3 mimetic (±) gossypol induces ROS-independent apoptosis and mitochondrial dysfunction in human A375 melanoma cells in vitro.
    Archives of toxicology, 2021, Volume: 95, Issue:4

    Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Cell Death; Cell Line, Tumor; Gossypol; Humans; Melano

2021
Combination therapy with BH3 mimetic and hyperthermia tends to be more effective on anti-melanoma treatment.
    Biochemical and biophysical research communications, 2018, 09-03, Volume: 503, Issue:1

    Topics: Animals; Apoptosis; BH3 Interacting Domain Death Agonist Protein; Biomimetics; Cell Line, Tumor; Cel

2018
BH3-mimetic gossypol-induced autophagic cell death in mutant BRAF melanoma cells with high expression of p21Cip¹.).
    Life sciences, 2014, Apr-25, Volume: 102, Issue:1

    Topics: Apoptosis; Apoptosis Regulatory Proteins; Autophagy; Beclin-1; Biomimetic Materials; Cell Line, Tumo

2014
A novel BH3 mimetic efficiently induces apoptosis in melanoma cells through direct binding to anti-apoptotic Bcl-2 family proteins, including phosphorylated Mcl-1.
    Pigment cell & melanoma research, 2015, Volume: 28, Issue:2

    Topics: Animals; Antineoplastic Agents; Apoptosis; Apoptosis Regulatory Proteins; bcl-2 Homologous Antagonis

2015
Integrated Genomics Identifies miR-32/MCL-1 Pathway as a Critical Driver of Melanomagenesis: Implications for miR-Replacement and Combination Therapy.
    PloS one, 2016, Volume: 11, Issue:11

    Topics: Animals; Carcinogenesis; Cell Line, Tumor; Cell Transformation, Neoplastic; Drug Synergism; Drug The

2016
[ANTINEOPLASTIC ACTIVITY OF GOSSYPOL IN EXPERIMENTAL TRANSPLANTED TUMORS].
    Voprosy onkologii, 1963, Volume: 9

    Topics: Animals; Antineoplastic Agents; Carcinoma 256, Walker; Carcinoma, Ehrlich Tumor; Carcinoma, Hepatoce

1963
THE SEARCH FOR ANTITUMOUR SUBSTANCES OF PLANT ORIGIN.
    Acta - Unio Internationalis Contra Cancrum, 1964, Volume: 20

    Topics: Animals; Antineoplastic Agents; Carcinoma, Ehrlich Tumor; Coumarins; Gossypol; Melanoma; Mice; Neopl

1964
Differential cytotoxic effect of gossypol on human melanoma, colon carcinoma, and other tissue culture cell lines.
    Cancer research, 1984, Volume: 44, Issue:2

    Topics: Breast Neoplasms; Cell Division; Cell Line; Colonic Neoplasms; Fibroblasts; Gossypol; Humans; Leukem

1984
Cytotoxicity of gossypol enantiomers and its quinone metabolite gossypolone in melanoma cell lines.
    Melanoma research, 1997, Volume: 7, Issue:5

    Topics: Cell Adhesion; Cell Division; Cell Line; Cell Survival; Dose-Response Relationship, Drug; Gossypol;

1997