gossypol has been researched along with Melanoma in 10 studies
Gossypol: A dimeric sesquiterpene found in cottonseed (GOSSYPIUM). The (-) isomer is active as a male contraceptive (CONTRACEPTIVE AGENTS, MALE) whereas toxic symptoms are associated with the (+) isomer.
Melanoma: A malignant neoplasm derived from cells that are capable of forming melanin, which may occur in the skin of any part of the body, in the eye, or, rarely, in the mucous membranes of the genitalia, anus, oral cavity, or other sites. It occurs mostly in adults and may originate de novo or from a pigmented nevus or malignant lentigo. Melanomas frequently metastasize widely, and the regional lymph nodes, liver, lungs, and brain are likely to be involved. The incidence of malignant skin melanomas is rising rapidly in all parts of the world. (Stedman, 25th ed; from Rook et al., Textbook of Dermatology, 4th ed, p2445)
| Excerpt | Relevance | Reference |
|---|---|---|
| "The aim of the present study was to identify the potential therapeutic effects of BH3-mimetic gossypol on melanoma cells with acquired resistance to BRAF inhibitors." | 7.80 | BH3-mimetic gossypol-induced autophagic cell death in mutant BRAF melanoma cells with high expression of p21Cip¹.). ( Jang, GH; Lee, M, 2014) |
| "The cytotoxicity of the (-)- and (+)-isomers and the quinone metabolite gossypolone prepared from the naturally occurring polyphenolic dialdehyde gossypol were compared using two human melanoma cell lines (SK-mel-19 and SK-mel-28) with a similar growth rate, one melanotic (melanin content of 69 pg/cell) and one amelanotic (melanin content of 10 pg/cell)." | 7.69 | Cytotoxicity of gossypol enantiomers and its quinone metabolite gossypolone in melanoma cell lines. ( Blackstaffe, L; Fish, RG; Shelley, MD, 1997) |
| "The aim of the present study was to identify the potential therapeutic effects of BH3-mimetic gossypol on melanoma cells with acquired resistance to BRAF inhibitors." | 3.80 | BH3-mimetic gossypol-induced autophagic cell death in mutant BRAF melanoma cells with high expression of p21Cip¹.). ( Jang, GH; Lee, M, 2014) |
| "The cytotoxicity of the (-)- and (+)-isomers and the quinone metabolite gossypolone prepared from the naturally occurring polyphenolic dialdehyde gossypol were compared using two human melanoma cell lines (SK-mel-19 and SK-mel-28) with a similar growth rate, one melanotic (melanin content of 69 pg/cell) and one amelanotic (melanin content of 10 pg/cell)." | 3.69 | Cytotoxicity of gossypol enantiomers and its quinone metabolite gossypolone in melanoma cell lines. ( Blackstaffe, L; Fish, RG; Shelley, MD, 1997) |
| "Malignant melanoma has shown increased incidence and high mortality rate in the last three decades." | 1.48 | Combination therapy with BH3 mimetic and hyperthermia tends to be more effective on anti-melanoma treatment. ( Guo, F; Lan, B; Li, X; Peng, B; Shi, Z; Wang, X; Zhang, G, 2018) |
| "Cutaneous malignant melanoma is among the deadliest human cancers, broadly resistant to most clinical therapies." | 1.43 | Integrated Genomics Identifies miR-32/MCL-1 Pathway as a Critical Driver of Melanomagenesis: Implications for miR-Replacement and Combination Therapy. ( Merlino, G; Mishra, PJ, 2016) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (30.00) | 18.7374 |
| 1990's | 1 (10.00) | 18.2507 |
| 2000's | 1 (10.00) | 29.6817 |
| 2010's | 4 (40.00) | 24.3611 |
| 2020's | 1 (10.00) | 2.80 |
| Authors | Studies |
|---|---|
| Nguyen, M | 1 |
| Marcellus, RC | 1 |
| Roulston, A | 1 |
| Watson, M | 1 |
| Serfass, L | 1 |
| Murthy Madiraju, SR | 1 |
| Goulet, D | 1 |
| Viallet, J | 1 |
| Bélec, L | 1 |
| Billot, X | 1 |
| Acoca, S | 1 |
| Purisima, E | 1 |
| Wiegmans, A | 1 |
| Cluse, L | 1 |
| Johnstone, RW | 1 |
| Beauparlant, P | 1 |
| Shore, GC | 1 |
| Haasler, L | 1 |
| Kondadi, AK | 1 |
| Tsigaras, T | 1 |
| von Montfort, C | 1 |
| Graf, P | 1 |
| Stahl, W | 1 |
| Brenneisen, P | 1 |
| Shi, Z | 1 |
| Lan, B | 1 |
| Peng, B | 1 |
| Wang, X | 1 |
| Zhang, G | 1 |
| Li, X | 1 |
| Guo, F | 1 |
| Jang, GH | 1 |
| Lee, M | 1 |
| Liu, Y | 1 |
| Xie, M | 1 |
| Song, T | 1 |
| Sheng, H | 1 |
| Yu, X | 1 |
| Zhang, Z | 1 |
| Mishra, PJ | 2 |
| Merlino, G | 1 |
| VERMEL, EM | 2 |
| KRUGLIAK, SA | 1 |
| Tuszynski, GP | 1 |
| Cossu, G | 1 |
| Blackstaffe, L | 1 |
| Shelley, MD | 1 |
| Fish, RG | 1 |
10 other studies available for gossypol and Melanoma
| Article | Year |
|---|---|
Small molecule obatoclax (GX15-070) antagonizes MCL-1 and overcomes MCL-1-mediated resistance to apoptosis.
Topics: Animals; Antineoplastic Agents; Apoptosis; bcl-2 Homologous Antagonist-Killer Protein; Boronic Acids | 2007 |
The BH3 mimetic (±) gossypol induces ROS-independent apoptosis and mitochondrial dysfunction in human A375 melanoma cells in vitro.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Cell Death; Cell Line, Tumor; Gossypol; Humans; Melano | 2021 |
Combination therapy with BH3 mimetic and hyperthermia tends to be more effective on anti-melanoma treatment.
Topics: Animals; Apoptosis; BH3 Interacting Domain Death Agonist Protein; Biomimetics; Cell Line, Tumor; Cel | 2018 |
BH3-mimetic gossypol-induced autophagic cell death in mutant BRAF melanoma cells with high expression of p21Cip¹.).
Topics: Apoptosis; Apoptosis Regulatory Proteins; Autophagy; Beclin-1; Biomimetic Materials; Cell Line, Tumo | 2014 |
A novel BH3 mimetic efficiently induces apoptosis in melanoma cells through direct binding to anti-apoptotic Bcl-2 family proteins, including phosphorylated Mcl-1.
Topics: Animals; Antineoplastic Agents; Apoptosis; Apoptosis Regulatory Proteins; bcl-2 Homologous Antagonis | 2015 |
Integrated Genomics Identifies miR-32/MCL-1 Pathway as a Critical Driver of Melanomagenesis: Implications for miR-Replacement and Combination Therapy.
Topics: Animals; Carcinogenesis; Cell Line, Tumor; Cell Transformation, Neoplastic; Drug Synergism; Drug The | 2016 |
[ANTINEOPLASTIC ACTIVITY OF GOSSYPOL IN EXPERIMENTAL TRANSPLANTED TUMORS].
Topics: Animals; Antineoplastic Agents; Carcinoma 256, Walker; Carcinoma, Ehrlich Tumor; Carcinoma, Hepatoce | 1963 |
THE SEARCH FOR ANTITUMOUR SUBSTANCES OF PLANT ORIGIN.
Topics: Animals; Antineoplastic Agents; Carcinoma, Ehrlich Tumor; Coumarins; Gossypol; Melanoma; Mice; Neopl | 1964 |
Differential cytotoxic effect of gossypol on human melanoma, colon carcinoma, and other tissue culture cell lines.
Topics: Breast Neoplasms; Cell Division; Cell Line; Colonic Neoplasms; Fibroblasts; Gossypol; Humans; Leukem | 1984 |
Cytotoxicity of gossypol enantiomers and its quinone metabolite gossypolone in melanoma cell lines.
Topics: Cell Adhesion; Cell Division; Cell Line; Cell Survival; Dose-Response Relationship, Drug; Gossypol; | 1997 |