gossypol has been researched along with Malignant Melanoma in 10 studies
Gossypol: A dimeric sesquiterpene found in cottonseed (GOSSYPIUM). The (-) isomer is active as a male contraceptive (CONTRACEPTIVE AGENTS, MALE) whereas toxic symptoms are associated with the (+) isomer.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The aim of the present study was to identify the potential therapeutic effects of BH3-mimetic gossypol on melanoma cells with acquired resistance to BRAF inhibitors." | 7.80 | BH3-mimetic gossypol-induced autophagic cell death in mutant BRAF melanoma cells with high expression of p21Cip¹.). ( Jang, GH; Lee, M, 2014) |
| "The cytotoxicity of the (-)- and (+)-isomers and the quinone metabolite gossypolone prepared from the naturally occurring polyphenolic dialdehyde gossypol were compared using two human melanoma cell lines (SK-mel-19 and SK-mel-28) with a similar growth rate, one melanotic (melanin content of 69 pg/cell) and one amelanotic (melanin content of 10 pg/cell)." | 7.69 | Cytotoxicity of gossypol enantiomers and its quinone metabolite gossypolone in melanoma cell lines. ( Blackstaffe, L; Fish, RG; Shelley, MD, 1997) |
| "The aim of the present study was to identify the potential therapeutic effects of BH3-mimetic gossypol on melanoma cells with acquired resistance to BRAF inhibitors." | 3.80 | BH3-mimetic gossypol-induced autophagic cell death in mutant BRAF melanoma cells with high expression of p21Cip¹.). ( Jang, GH; Lee, M, 2014) |
| "The cytotoxicity of the (-)- and (+)-isomers and the quinone metabolite gossypolone prepared from the naturally occurring polyphenolic dialdehyde gossypol were compared using two human melanoma cell lines (SK-mel-19 and SK-mel-28) with a similar growth rate, one melanotic (melanin content of 69 pg/cell) and one amelanotic (melanin content of 10 pg/cell)." | 3.69 | Cytotoxicity of gossypol enantiomers and its quinone metabolite gossypolone in melanoma cell lines. ( Blackstaffe, L; Fish, RG; Shelley, MD, 1997) |
| "Malignant melanoma has shown increased incidence and high mortality rate in the last three decades." | 1.48 | Combination therapy with BH3 mimetic and hyperthermia tends to be more effective on anti-melanoma treatment. ( Guo, F; Lan, B; Li, X; Peng, B; Shi, Z; Wang, X; Zhang, G, 2018) |
| "Cutaneous malignant melanoma is among the deadliest human cancers, broadly resistant to most clinical therapies." | 1.43 | Integrated Genomics Identifies miR-32/MCL-1 Pathway as a Critical Driver of Melanomagenesis: Implications for miR-Replacement and Combination Therapy. ( Merlino, G; Mishra, PJ, 2016) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (30.00) | 18.7374 |
| 1990's | 1 (10.00) | 18.2507 |
| 2000's | 1 (10.00) | 29.6817 |
| 2010's | 4 (40.00) | 24.3611 |
| 2020's | 1 (10.00) | 2.80 |
| Authors | Studies |
|---|---|
| Nguyen, M | 1 |
| Marcellus, RC | 1 |
| Roulston, A | 1 |
| Watson, M | 1 |
| Serfass, L | 1 |
| Murthy Madiraju, SR | 1 |
| Goulet, D | 1 |
| Viallet, J | 1 |
| Bélec, L | 1 |
| Billot, X | 1 |
| Acoca, S | 1 |
| Purisima, E | 1 |
| Wiegmans, A | 1 |
| Cluse, L | 1 |
| Johnstone, RW | 1 |
| Beauparlant, P | 1 |
| Shore, GC | 1 |
| Haasler, L | 1 |
| Kondadi, AK | 1 |
| Tsigaras, T | 1 |
| von Montfort, C | 1 |
| Graf, P | 1 |
| Stahl, W | 1 |
| Brenneisen, P | 1 |
| Shi, Z | 1 |
| Lan, B | 1 |
| Peng, B | 1 |
| Wang, X | 1 |
| Zhang, G | 1 |
| Li, X | 1 |
| Guo, F | 1 |
| Jang, GH | 1 |
| Lee, M | 1 |
| Liu, Y | 1 |
| Xie, M | 1 |
| Song, T | 1 |
| Sheng, H | 1 |
| Yu, X | 1 |
| Zhang, Z | 1 |
| Mishra, PJ | 2 |
| Merlino, G | 1 |
| VERMEL, EM | 2 |
| KRUGLIAK, SA | 1 |
| Tuszynski, GP | 1 |
| Cossu, G | 1 |
| Blackstaffe, L | 1 |
| Shelley, MD | 1 |
| Fish, RG | 1 |
10 other studies available for gossypol and Malignant Melanoma
| Article | Year |
|---|---|
Small molecule obatoclax (GX15-070) antagonizes MCL-1 and overcomes MCL-1-mediated resistance to apoptosis.
Topics: Animals; Antineoplastic Agents; Apoptosis; bcl-2 Homologous Antagonist-Killer Protein; Boronic Acids | 2007 |
The BH3 mimetic (±) gossypol induces ROS-independent apoptosis and mitochondrial dysfunction in human A375 melanoma cells in vitro.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Cell Death; Cell Line, Tumor; Gossypol; Humans; Melano | 2021 |
Combination therapy with BH3 mimetic and hyperthermia tends to be more effective on anti-melanoma treatment.
Topics: Animals; Apoptosis; BH3 Interacting Domain Death Agonist Protein; Biomimetics; Cell Line, Tumor; Cel | 2018 |
BH3-mimetic gossypol-induced autophagic cell death in mutant BRAF melanoma cells with high expression of p21Cip¹.).
Topics: Apoptosis; Apoptosis Regulatory Proteins; Autophagy; Beclin-1; Biomimetic Materials; Cell Line, Tumo | 2014 |
A novel BH3 mimetic efficiently induces apoptosis in melanoma cells through direct binding to anti-apoptotic Bcl-2 family proteins, including phosphorylated Mcl-1.
Topics: Animals; Antineoplastic Agents; Apoptosis; Apoptosis Regulatory Proteins; bcl-2 Homologous Antagonis | 2015 |
Integrated Genomics Identifies miR-32/MCL-1 Pathway as a Critical Driver of Melanomagenesis: Implications for miR-Replacement and Combination Therapy.
Topics: Animals; Carcinogenesis; Cell Line, Tumor; Cell Transformation, Neoplastic; Drug Synergism; Drug The | 2016 |
[ANTINEOPLASTIC ACTIVITY OF GOSSYPOL IN EXPERIMENTAL TRANSPLANTED TUMORS].
Topics: Animals; Antineoplastic Agents; Carcinoma 256, Walker; Carcinoma, Ehrlich Tumor; Carcinoma, Hepatoce | 1963 |
THE SEARCH FOR ANTITUMOUR SUBSTANCES OF PLANT ORIGIN.
Topics: Animals; Antineoplastic Agents; Carcinoma, Ehrlich Tumor; Coumarins; Gossypol; Melanoma; Mice; Neopl | 1964 |
Differential cytotoxic effect of gossypol on human melanoma, colon carcinoma, and other tissue culture cell lines.
Topics: Breast Neoplasms; Cell Division; Cell Line; Colonic Neoplasms; Fibroblasts; Gossypol; Humans; Leukem | 1984 |
Cytotoxicity of gossypol enantiomers and its quinone metabolite gossypolone in melanoma cell lines.
Topics: Cell Adhesion; Cell Division; Cell Line; Cell Survival; Dose-Response Relationship, Drug; Gossypol; | 1997 |