gossypol has been researched along with Lymph Node Metastasis in 3 studies
Gossypol: A dimeric sesquiterpene found in cottonseed (GOSSYPIUM). The (-) isomer is active as a male contraceptive (CONTRACEPTIVE AGENTS, MALE) whereas toxic symptoms are associated with the (+) isomer.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Patients with metastatic prostate cancer scheduled to start, or who had recently (within 6 weeks) initiated, ADT were enrolled." | 2.82 | A Phase II Study of AT-101 to Overcome Bcl-2--Mediated Resistance to Androgen Deprivation Therapy in Patients With Newly Diagnosed Castration-Sensitive Metastatic Prostate Cancer. ( DiPaola, RS; Goodin, S; Hussain, M; Jeyamohan, C; Kaufman, HL; Liu, G; Mehnert, J; Stadler, WM; Stein, MN; Tereshchenko, IV, 2016) |
| "AT-101 (A), a small molecule oral inhibitor of the Bcl-2 family, has activity alone and in combination with docetaxel (Taxotere) and prednisone (DP) in metastatic castration-resistant prostate cancer (mCRPC)." | 2.77 | Randomized phase II trial of docetaxel plus prednisone in combination with placebo or AT-101, an oral small molecule Bcl-2 family antagonist, as first-line therapy for metastatic castration-resistant prostate cancer. ( Berry, WR; Brookes, M; Burke, JM; Caton, JR; Fleming, MT; Galsky, MD; Holmlund, JT; Hutson, TE; Karlov, P; Leopold, L; Matveev, V; Sonpavde, G; Wood, BA, 2012) |
| "Gossypol-treated rats exhibited weight reductions in developed MAT-LyLu prostate tumor mass and prostate of 24% (p < 0." | 1.29 | Antiproliferative and antimetastatic effects of gossypol on Dunning prostate cell-bearing Copenhagen rats. ( Brueggemeier, RW; Chang, CJ; Ghosh, PK; Hu, YF; Lin, YC, 1993) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (33.33) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (66.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Stein, MN | 1 |
| Hussain, M | 1 |
| Stadler, WM | 1 |
| Liu, G | 1 |
| Tereshchenko, IV | 1 |
| Goodin, S | 1 |
| Jeyamohan, C | 1 |
| Kaufman, HL | 1 |
| Mehnert, J | 1 |
| DiPaola, RS | 1 |
| Sonpavde, G | 1 |
| Matveev, V | 1 |
| Burke, JM | 1 |
| Caton, JR | 1 |
| Fleming, MT | 1 |
| Hutson, TE | 1 |
| Galsky, MD | 1 |
| Berry, WR | 1 |
| Karlov, P | 1 |
| Holmlund, JT | 1 |
| Wood, BA | 1 |
| Brookes, M | 1 |
| Leopold, L | 1 |
| Chang, CJ | 1 |
| Ghosh, PK | 1 |
| Hu, YF | 1 |
| Brueggemeier, RW | 1 |
| Lin, YC | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Randomized, Double Blind, Placebo-controlled Multiple-center Phase III Trial of Gossypol Combined With Docetaxel and Cisplatin Scheme in Advanced Non Small-cell Lung Cancers With APE1 High Expression[NCT01977209] | Phase 3 | 204 participants (Anticipated) | Interventional | 2013-09-30 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 trials available for gossypol and Lymph Node Metastasis
| Article | Year |
|---|---|
A Phase II Study of AT-101 to Overcome Bcl-2--Mediated Resistance to Androgen Deprivation Therapy in Patients With Newly Diagnosed Castration-Sensitive Metastatic Prostate Cancer.
Topics: Adenocarcinoma; Aged; Aged, 80 and over; Androgen Antagonists; Antineoplastic Combined Chemotherapy | 2016 |
Randomized phase II trial of docetaxel plus prednisone in combination with placebo or AT-101, an oral small molecule Bcl-2 family antagonist, as first-line therapy for metastatic castration-resistant prostate cancer.
Topics: Adenocarcinoma; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Bone Neopla | 2012 |
1 other study available for gossypol and Lymph Node Metastasis
| Article | Year |
|---|---|
Antiproliferative and antimetastatic effects of gossypol on Dunning prostate cell-bearing Copenhagen rats.
Topics: Androgens; Animals; Antineoplastic Agents; Cell Division; Genitalia, Male; Gossypol; Lung Neoplasms; | 1993 |