gossypol has been researched along with Local Neoplasm Recurrence in 6 studies
Gossypol: A dimeric sesquiterpene found in cottonseed (GOSSYPIUM). The (-) isomer is active as a male contraceptive (CONTRACEPTIVE AGENTS, MALE) whereas toxic symptoms are associated with the (+) isomer.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Given the evidence of activity in xenograft models, treatment with AT-101 in combination with docetaxel is a therapeutic doublet of interest in metastatic head and neck squamous cell carcinoma." | 2.82 | A phase II trial of the BCL-2 homolog domain 3 mimetic AT-101 in combination with docetaxel for recurrent, locally advanced, or metastatic head and neck cancer. ( Bellile, E; Bradford, C; Carey, TE; Chepeha, DB; Eisbruch, A; Jackson, TL; Malloy, K; McKean, E; McLean, S; Moyer, J; Nör, JE; Pearson, AT; Prince, M; Sacco, AG; Shuman, A; Spector, ME; Sukari, A; Swiecicki, PL; Taylor, JM; Wang, S; Wolf, GT; Worden, FP, 2016) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (16.67) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 4 (66.67) | 24.3611 |
| 2020's | 1 (16.67) | 2.80 |
| Authors | Studies |
|---|---|
| Hellmold, D | 1 |
| Kubelt, C | 1 |
| Daunke, T | 1 |
| Beckinger, S | 1 |
| Janssen, O | 1 |
| Hauck, M | 1 |
| Schütt, F | 1 |
| Adelung, R | 1 |
| Lucius, R | 1 |
| Haag, J | 1 |
| Sebens, S | 1 |
| Synowitz, M | 1 |
| Held-Feindt, J | 1 |
| Swiecicki, PL | 1 |
| Bellile, E | 1 |
| Sacco, AG | 1 |
| Pearson, AT | 1 |
| Taylor, JM | 1 |
| Jackson, TL | 1 |
| Chepeha, DB | 1 |
| Spector, ME | 1 |
| Shuman, A | 1 |
| Malloy, K | 1 |
| Moyer, J | 1 |
| McKean, E | 1 |
| McLean, S | 1 |
| Sukari, A | 1 |
| Wolf, GT | 1 |
| Eisbruch, A | 1 |
| Prince, M | 1 |
| Bradford, C | 1 |
| Carey, TE | 1 |
| Wang, S | 1 |
| Nör, JE | 1 |
| Worden, FP | 1 |
| Heist, RS | 1 |
| Fain, J | 1 |
| Chinnasami, B | 1 |
| Khan, W | 1 |
| Molina, JR | 1 |
| Sequist, LV | 1 |
| Temel, JS | 1 |
| Fidias, P | 1 |
| Brainerd, V | 1 |
| Leopold, L | 2 |
| Lynch, TJ | 1 |
| Pond, GR | 1 |
| Armstrong, AJ | 1 |
| Wood, BA | 1 |
| Brookes, M | 1 |
| Berry, WR | 1 |
| de Wit, R | 1 |
| Eisenberger, MA | 1 |
| Tannock, IF | 1 |
| Sonpavde, G | 1 |
| Baggstrom, MQ | 1 |
| Qi, Y | 1 |
| Koczywas, M | 1 |
| Argiris, A | 1 |
| Johnson, EA | 1 |
| Millward, MJ | 1 |
| Murphy, SC | 1 |
| Erlichman, C | 1 |
| Rudin, CM | 1 |
| Govindan, R | 1 |
| Bushunow, P | 1 |
| Reidenberg, MM | 1 |
| Wasenko, J | 1 |
| Winfield, J | 1 |
| Lorenzo, B | 1 |
| Lemke, S | 1 |
| Himpler, B | 1 |
| Corona, R | 1 |
| Coyle, T | 1 |
3 trials available for gossypol and Local Neoplasm Recurrence
| Article | Year |
|---|---|
A phase II trial of the BCL-2 homolog domain 3 mimetic AT-101 in combination with docetaxel for recurrent, locally advanced, or metastatic head and neck cancer.
Topics: Adult; Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squam | 2016 |
Phase I/II study of AT-101 with topotecan in relapsed and refractory small cell lung cancer.
Topics: Adenocarcinoma; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Cohort Studies; Drug Re | 2010 |
A phase II study of AT-101 (Gossypol) in chemotherapy-sensitive recurrent extensive-stage small cell lung cancer.
Topics: Aged; Contraceptive Agents, Male; Drug Resistance, Neoplasm; Female; Follow-Up Studies; Gossypol; Hu | 2011 |
3 other studies available for gossypol and Local Neoplasm Recurrence
| Article | Year |
|---|---|
Sequential Treatment with Temozolomide Plus Naturally Derived AT101 as an Alternative Therapeutic Strategy: Insights into Chemoresistance Mechanisms of Surviving Glioblastoma Cells.
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Cell Line, Tumor; Drug Resistance, Neoplasm; Gli | 2023 |
Evaluating the value of number of cycles of docetaxel and prednisone in men with metastatic castration-resistant prostate cancer.
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Clinical Trials as Topic; Dise | 2012 |
Gossypol treatment of recurrent adult malignant gliomas.
Topics: Adult; Aged; Brain Neoplasms; Disease-Free Survival; Female; Glioma; Gossypol; Humans; Male; Middle | 1999 |