gossypol has been researched along with Liver Neoplasms in 13 studies
Gossypol: A dimeric sesquiterpene found in cottonseed (GOSSYPIUM). The (-) isomer is active as a male contraceptive (CONTRACEPTIVE AGENTS, MALE) whereas toxic symptoms are associated with the (+) isomer.
Liver Neoplasms: Tumors or cancer of the LIVER.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Epirubicin (EPI)-based transarterial chemoembolization is an effective therapy for advanced hepatocellular carcinoma (HCC)." | 8.12 | (-)-Gossypol enhances the anticancer activity of epirubicin via downregulating survivin in hepatocellular carcinoma. ( He, F; Jiang, W; Li, B; Li, H; Lian, J; Ma, T; Sun, L; Wang, W; Wu, Y; Xiao, Y; Yan, X, 2022) |
| "To investigate the in vitro and in vivo activities and related mechanism of apogossypolone (ApoG2) alone or in combination with adriamycin (ADM) against human hepatocellular carcinoma (HCC)." | 7.74 | Synergistic antitumoral activity and induction of apoptosis by novel pan Bcl-2 proteins inhibitor apogossypolone with adriamycin in human hepatocellular carcinoma. ( Mi, JX; Ni, XY; Sun, XQ; Tang, JM; Wang, GF; Wang, HB; Yang, DJ; Zhang, XW, 2008) |
| "Gossypol has been shown to have an anti-HCC effect, but the underlying mechanism requires further study." | 5.51 | Dual effects of gossypol on human hepatocellular carcinoma via endoplasmic reticulum stress and autophagy. ( Cao, Y; Chen, W; Ji, A; Jiang, C; Qiang, G; Wang, Z; Wu, J; Zhang, G, 2019) |
| "Epirubicin (EPI)-based transarterial chemoembolization is an effective therapy for advanced hepatocellular carcinoma (HCC)." | 4.12 | (-)-Gossypol enhances the anticancer activity of epirubicin via downregulating survivin in hepatocellular carcinoma. ( He, F; Jiang, W; Li, B; Li, H; Lian, J; Ma, T; Sun, L; Wang, W; Wu, Y; Xiao, Y; Yan, X, 2022) |
| "To investigate the in vitro and in vivo activities and related mechanism of apogossypolone (ApoG2) alone or in combination with adriamycin (ADM) against human hepatocellular carcinoma (HCC)." | 3.74 | Synergistic antitumoral activity and induction of apoptosis by novel pan Bcl-2 proteins inhibitor apogossypolone with adriamycin in human hepatocellular carcinoma. ( Mi, JX; Ni, XY; Sun, XQ; Tang, JM; Wang, GF; Wang, HB; Yang, DJ; Zhang, XW, 2008) |
| "Gossypol has been shown to have an anti-HCC effect, but the underlying mechanism requires further study." | 1.51 | Dual effects of gossypol on human hepatocellular carcinoma via endoplasmic reticulum stress and autophagy. ( Cao, Y; Chen, W; Ji, A; Jiang, C; Qiang, G; Wang, Z; Wu, J; Zhang, G, 2019) |
| "Gossypol is a natural toxicant present in cottonseeds, and is hepatotoxic to animals and human." | 1.32 | Effect of gossypol on intracellular Ca2+ regulation in human hepatoma cells. ( Chen, WC; Cheng, HH; Cheng, JS; Jan, CR; Liu, CP; Lo, YK; Yeh, JH, 2003) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (53.85) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (15.38) | 29.6817 |
| 2010's | 3 (23.08) | 24.3611 |
| 2020's | 1 (7.69) | 2.80 |
| Authors | Studies |
|---|---|
| Jiang, W | 1 |
| Wang, W | 1 |
| Sun, L | 1 |
| Xiao, Y | 1 |
| Ma, T | 1 |
| Li, B | 1 |
| Yan, X | 1 |
| Wu, Y | 2 |
| Li, H | 1 |
| Lian, J | 3 |
| He, F | 3 |
| Zhang, G | 1 |
| Wang, Z | 1 |
| Chen, W | 1 |
| Cao, Y | 1 |
| Wu, J | 2 |
| Qiang, G | 1 |
| Ji, A | 1 |
| Jiang, C | 1 |
| Wang, B | 2 |
| Chen, L | 1 |
| Ni, Z | 2 |
| Dai, X | 2 |
| Qin, L | 1 |
| Li, X | 1 |
| Xu, L | 2 |
| Mi, JX | 1 |
| Wang, GF | 1 |
| Wang, HB | 1 |
| Sun, XQ | 1 |
| Ni, XY | 1 |
| Zhang, XW | 1 |
| Tang, JM | 1 |
| Yang, DJ | 1 |
| Cheng, P | 1 |
| Ding, W | 1 |
| Rae Smith, A | 1 |
| Wu, D | 1 |
| VERMEL, EM | 1 |
| KRUGLIAK, SA | 1 |
| Cheng, JS | 1 |
| Lo, YK | 1 |
| Yeh, JH | 1 |
| Cheng, HH | 1 |
| Liu, CP | 1 |
| Chen, WC | 1 |
| Jan, CR | 1 |
| Zhang, JF | 1 |
| Zhang, JB | 1 |
| Yuan, J | 1 |
| Ding, LA | 1 |
| Chen, JY | 1 |
| Wang, JT | 1 |
| Wang, YB | 1 |
| Pan, SR | 1 |
| Wang, SH | 1 |
| Chang, LH | 1 |
| Benz, C | 1 |
| Keniry, M | 1 |
| Goldberg, H | 1 |
| Sinnhuber, RO | 1 |
| Lee, DJ | 1 |
| Wales, JH | 1 |
| Ayres, JL | 1 |
| Ghittino, P | 1 |
| Provana, A | 1 |
| Codegone, ML | 1 |
1 review available for gossypol and Liver Neoplasms
| Article | Year |
|---|---|
Cottonseed meal and tumors.
Topics: Aflatoxins; Animal Feed; Animals; Carcinoma, Hepatocellular; Cycloparaffins; Dietary Fats; Drug Syne | 1969 |
12 other studies available for gossypol and Liver Neoplasms
| Article | Year |
|---|---|
(-)-Gossypol enhances the anticancer activity of epirubicin via downregulating survivin in hepatocellular carcinoma.
Topics: Animals; Apoptosis; Carcinoma, Hepatocellular; Cell Line, Tumor; Chemoembolization, Therapeutic; Epi | 2022 |
Dual effects of gossypol on human hepatocellular carcinoma via endoplasmic reticulum stress and autophagy.
Topics: Animals; Apoptosis; Autophagy; Carcinoma, Hepatocellular; Cell Line, Tumor; Contraceptive Agents, Ma | 2019 |
Hsp90 inhibitor 17-AAG sensitizes Bcl-2 inhibitor (-)-gossypol by suppressing ERK-mediated protective autophagy and Mcl-1 accumulation in hepatocellular carcinoma cells.
Topics: Apoptosis; Apoptosis Regulatory Proteins; Autophagy; Beclin-1; Benzoquinones; Carcinoma, Hepatocellu | 2014 |
Synergistic antitumoral activity and induction of apoptosis by novel pan Bcl-2 proteins inhibitor apogossypolone with adriamycin in human hepatocellular carcinoma.
Topics: Animals; Antibiotics, Antineoplastic; Apoptosis; Carcinoma, Hepatocellular; Cell Line, Tumor; Dose-R | 2008 |
The novel BH-3 mimetic apogossypolone induces Beclin-1- and ROS-mediated autophagy in human hepatocellular carcinoma [corrected] cells.
Topics: Acetylcysteine; Antineoplastic Agents; Antioxidants; Apoptosis Regulatory Proteins; Autophagy; bcl-X | 2013 |
[ANTINEOPLASTIC ACTIVITY OF GOSSYPOL IN EXPERIMENTAL TRANSPLANTED TUMORS].
Topics: Animals; Antineoplastic Agents; Carcinoma 256, Walker; Carcinoma, Ehrlich Tumor; Carcinoma, Hepatoce | 1963 |
Effect of gossypol on intracellular Ca2+ regulation in human hepatoma cells.
Topics: Calcium; Calcium Channel Blockers; Calcium Signaling; Carcinoma, Hepatocellular; Cell Line, Tumor; C | 2003 |
[Experimental studies on the cytotoxic effect of gossypol in mice, rats and human tumor cell lines and its possible mechanism].
Topics: Animals; Antineoplastic Agents, Phytogenic; Cell Line; DNA; Gossypol; HeLa Cells; Humans; Isoenzymes | 1986 |
[Hepatoma initiating and promoting effects of gossypol].
Topics: Animals; Carcinoma, Hepatocellular; Gossypol; Liver Neoplasms; Male; Rats; Rats, Inbred Strains | 1985 |
Selective toxicity of gossypol against epithelial tumors and its detection by magnetic resonance spectroscopy.
Topics: Animals; Bone Marrow; Epithelium; Gossypol; Humans; Isoenzymes; L-Lactate Dehydrogenase; Liver Neopl | 1988 |
Dietary factors and hepatoma in rainbow trout (Salmo gairdneri). II. Cocarcinogenes by cyclopropenoid fatty acids and the effect of gossypol and altered lipids on aflatoxin-induced liver cancer.
Topics: Aflatoxins; Animal Feed; Animals; Carcinogens; Carcinoma, Hepatocellular; Coumarins; Fatty Acids; Go | 1968 |
Experimental dietary hepatoma in rainbow trout. The role of cottonseed meals and other diets.
Topics: Acetates; Aflatoxins; Animals; Arachis; Caprylates; Carcinogens; Carcinoma, Hepatocellular; Cottonse | 1967 |