gossypol has been researched along with Leukemia, Myeloid, Acute in 3 studies
Gossypol: A dimeric sesquiterpene found in cottonseed (GOSSYPIUM). The (-) isomer is active as a male contraceptive (CONTRACEPTIVE AGENTS, MALE) whereas toxic symptoms are associated with the (+) isomer.
Leukemia, Myeloid, Acute: Clonal expansion of myeloid blasts in bone marrow, blood, and other tissue. Myeloid leukemias develop from changes in cells that normally produce NEUTROPHILS; BASOPHILS; EOSINOPHILS; and MONOCYTES.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 3 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Zhang, L | 2 |
| Zhou, Y | 2 |
| Chen, K | 2 |
| Shi, P | 1 |
| Li, Y | 1 |
| Deng, M | 1 |
| Jiang, Z | 1 |
| Wang, X | 1 |
| Li, P | 1 |
| Xu, B | 2 |
| Yang, Q | 1 |
| Feng, L | 1 |
| Fu, G | 2 |
| Jiang, S | 1 |
| Bi, S | 1 |
| Lin, C | 1 |
| Zhao, H | 1 |
| Chen, XL | 1 |
| Pan, R | 1 |
| Ruvolo, VR | 1 |
| Wei, J | 1 |
| Konopleva, M | 1 |
| Reed, JC | 1 |
| Pellecchia, M | 1 |
| Andreeff, M | 1 |
| Ruvolo, PP | 1 |
3 other studies available for gossypol and Leukemia, Myeloid, Acute
| Article | Year |
|---|---|
The pan-Bcl2 Inhibitor AT101 Activates the Intrinsic Apoptotic Pathway and Causes DNA Damage in Acute Myeloid Leukemia Stem-Like Cells.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Cell Proliferation; DNA Damage; Gossypol; Humans; Leuk | 2017 |
Synthetic lethality of combined AT-101 with idarubicin in acute myeloid leukemia via blockade of DNA repair and activation of intrinsic apoptotic pathway.
Topics: Adolescent; Adult; Aged; Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Biomark | 2019 |
Inhibition of Mcl-1 with the pan-Bcl-2 family inhibitor (-)BI97D6 overcomes ABT-737 resistance in acute myeloid leukemia.
Topics: Animals; Apoptosis; Biphenyl Compounds; Blotting, Western; Cell Proliferation; Drug Resistance, Neop | 2015 |