gossypol has been researched along with Leukemia, Myelogenous, Chronic, BCR-ABL Positive in 2 studies
Gossypol: A dimeric sesquiterpene found in cottonseed (GOSSYPIUM). The (-) isomer is active as a male contraceptive (CONTRACEPTIVE AGENTS, MALE) whereas toxic symptoms are associated with the (+) isomer.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive: Clonal hematopoetic disorder caused by an acquired genetic defect in PLURIPOTENT STEM CELLS. It starts in MYELOID CELLS of the bone marrow, invades the blood and then other organs. The condition progresses from a stable, more indolent, chronic phase (LEUKEMIA, MYELOID, CHRONIC PHASE) lasting up to 7 years, to an advanced phase composed of an accelerated phase (LEUKEMIA, MYELOID, ACCELERATED PHASE) and BLAST CRISIS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Gossypol is a natural polyphenolic compound isolated from cottonseed and has antiproliferative activity in a variety of cancer cell lines." | 1.34 | (-)Gossypol and its combination with imatinib induce apoptosis in human chronic myeloid leukemic cells. ( Chen, X; Fu, J; Li, H; Li, J; Li, Y; Liu, H; Liu, Y; Meng, Y, 2007) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ergun, MA | 1 |
| Konac, E | 1 |
| Erbas, D | 1 |
| Ekmekci, A | 1 |
| Meng, Y | 1 |
| Li, Y | 1 |
| Li, J | 1 |
| Li, H | 1 |
| Fu, J | 1 |
| Liu, Y | 1 |
| Liu, H | 1 |
| Chen, X | 1 |
2 other studies available for gossypol and Leukemia, Myelogenous, Chronic, BCR-ABL Positive
| Article | Year |
|---|---|
Apoptosis and nitric oxide release induced by thalidomide, gossypol and dexamethasone in cultured human chronic myelogenous leukemic K-562 cells.
Topics: Apoptosis; Contraceptive Agents, Male; Dexamethasone; Dose-Response Relationship, Drug; Glucocortico | 2004 |
(-)Gossypol and its combination with imatinib induce apoptosis in human chronic myeloid leukemic cells.
Topics: Apoptosis; bcl-X Protein; Benzamides; Caspase 3; Cell Proliferation; Cytochromes c; Down-Regulation; | 2007 |