gossypol has been researched along with Leucocythaemia in 11 studies
Gossypol: A dimeric sesquiterpene found in cottonseed (GOSSYPIUM). The (-) isomer is active as a male contraceptive (CONTRACEPTIVE AGENTS, MALE) whereas toxic symptoms are associated with the (+) isomer.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Gossypol treatment resulted in a decrease of c-Myc expression and binding activity." | 5.35 | Gossypol suppresses telomerase activity in human leukemia cells via regulating hTERT. ( Choi, YH; Kim, GY; Kim, MO; Kim, ND; Lee, HG; Moon, DO, 2008) |
| "Treatment with gossypol also downregulated expression of NF-kappaB-regulated gene products, including inhibitor of apoptosis protein (IAP)-1, IAP-2, and X-linked IAP." | 5.35 | Gossypol suppresses NF-kappaB activity and NF-kappaB-related gene expression in human leukemia U937 cells. ( Kim, GY; Kim, MO; Lee, JD; Moon, DO, 2008) |
| "Gossypol inhibited 5- and 12-lipoxygenases of rat basophilic leukemia (RBL-1) cells with ID50 of 0." | 3.67 | Gossypol, a potent inhibitor of arachidonate 5- and 12-lipoxygenases. ( Hamasaki, Y; Tai, HH, 1985) |
| "Gossypol treatment resulted in a decrease of c-Myc expression and binding activity." | 1.35 | Gossypol suppresses telomerase activity in human leukemia cells via regulating hTERT. ( Choi, YH; Kim, GY; Kim, MO; Kim, ND; Lee, HG; Moon, DO, 2008) |
| " Hepatotoxicity and gastrointestinal toxicity represented the major adverse activities of gossypol, with apogossypol far less toxic." | 1.35 | Bcl-2 antagonist apogossypol (NSC736630) displays single-agent activity in Bcl-2-transgenic mice and has superior efficacy with less toxicity compared with gossypol (NSC19048). ( Jia, L; Kitada, S; Krajewska, M; Kress, CL; Pellecchia, M; Reed, JC, 2008) |
| "Treatment with gossypol also downregulated expression of NF-kappaB-regulated gene products, including inhibitor of apoptosis protein (IAP)-1, IAP-2, and X-linked IAP." | 1.35 | Gossypol suppresses NF-kappaB activity and NF-kappaB-related gene expression in human leukemia U937 cells. ( Kim, GY; Kim, MO; Lee, JD; Moon, DO, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (18.18) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 5 (45.45) | 29.6817 |
| 2010's | 4 (36.36) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Das, SG | 1 |
| Doshi, JM | 1 |
| Tian, D | 1 |
| Addo, SN | 1 |
| Srinivasan, B | 1 |
| Hermanson, DL | 1 |
| Xing, C | 1 |
| Vizirianakis, IS | 1 |
| Chatzopoulou, M | 1 |
| Bonovolias, ID | 1 |
| Nicolaou, I | 1 |
| Demopoulos, VJ | 1 |
| Tsiftsoglou, AS | 1 |
| Li, G | 1 |
| Liu, L | 1 |
| Shan, C | 1 |
| Cheng, Q | 1 |
| Budhraja, A | 1 |
| Zhou, T | 1 |
| Cui, H | 1 |
| Gao, N | 1 |
| Zhang, SD | 1 |
| Shan, L | 1 |
| Li, W | 1 |
| Li, HL | 1 |
| Zhang, WD | 1 |
| Moon, DO | 2 |
| Kim, MO | 2 |
| Choi, YH | 1 |
| Lee, HG | 1 |
| Kim, ND | 1 |
| Kim, GY | 2 |
| Goff, DJ | 1 |
| Court Recart, A | 1 |
| Sadarangani, A | 1 |
| Chun, HJ | 1 |
| Barrett, CL | 1 |
| Krajewska, M | 2 |
| Leu, H | 1 |
| Low-Marchelli, J | 1 |
| Ma, W | 1 |
| Shih, AY | 1 |
| Wei, J | 1 |
| Zhai, D | 1 |
| Geron, I | 1 |
| Pu, M | 1 |
| Bao, L | 1 |
| Chuang, R | 1 |
| Balaian, L | 1 |
| Gotlib, J | 1 |
| Minden, M | 1 |
| Martinelli, G | 1 |
| Rusert, J | 1 |
| Dao, KH | 1 |
| Shazand, K | 1 |
| Wentworth, P | 1 |
| Smith, KM | 1 |
| Jamieson, CA | 1 |
| Morris, SR | 1 |
| Messer, K | 1 |
| Goldstein, LS | 1 |
| Hudson, TJ | 1 |
| Marra, M | 1 |
| Frazer, KA | 1 |
| Pellecchia, M | 2 |
| Reed, JC | 2 |
| Jamieson, CH | 1 |
| Cleverley, J | 1 |
| Kitada, S | 1 |
| Kress, CL | 1 |
| Jia, L | 1 |
| Lee, JD | 1 |
| Hamasaki, Y | 2 |
| Miyazaki, S | 1 |
| Tai, HH | 2 |
1 review available for gossypol and Leucocythaemia
| Article | Year |
|---|---|
Toward the development of innovative bifunctional agents to induce differentiation and to promote apoptosis in leukemia: clinical candidates and perspectives.
Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Differentiation; Clinical Trials as Topic; Drug Eval | 2010 |
10 other studies available for gossypol and Leucocythaemia
| Article | Year |
|---|---|
Structure-activity relationship and molecular mechanisms of ethyl 2-amino-4-(2-ethoxy-2-oxoethyl)-6-phenyl-4h-chromene-3-carboxylate (sha 14-1) and its analogues.
Topics: Apoptosis; Benzopyrans; Camptothecin; Cell Line, Tumor; Drug Resistance, Neoplasm; Humans; Leukemia; | 2009 |
RhoA/ROCK/PTEN signaling is involved in AT-101-mediated apoptosis in human leukemia cells in vitro and in vivo.
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Caspase 3; Cell Line, Tumor; Gossypol; Humans; Leuke | 2014 |
Isochamaejasmin induces apoptosis in leukemia cells through inhibiting Bcl-2 family proteins.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; bcl-2-Associated X Protein; Biflavonoids; Caspase 3; C | 2015 |
Gossypol suppresses telomerase activity in human leukemia cells via regulating hTERT.
Topics: Active Transport, Cell Nucleus; Apoptosis; Cell Line, Tumor; Cell Proliferation; Contraceptive Agent | 2008 |
A Pan-BCL2 inhibitor renders bone-marrow-resident human leukemia stem cells sensitive to tyrosine kinase inhibition.
Topics: Blast Crisis; Gossypol; Humans; Leukemia; Neoplastic Stem Cells; Protein Kinase Inhibitors; Proto-On | 2013 |
American Society of Clinical Oncology--42nd annual meeting. Poster presentations on leukemia and cytotoxic chemotherapy. 2-6 June 2006, Atlanta, GA, USA.
Topics: Clinical Trials as Topic; Cytarabine; Drug Combinations; Gossypol; Humans; Leukemia; Mastocytosis, S | 2006 |
Bcl-2 antagonist apogossypol (NSC736630) displays single-agent activity in Bcl-2-transgenic mice and has superior efficacy with less toxicity compared with gossypol (NSC19048).
Topics: Animals; B-Lymphocytes; Cell Survival; Cells, Cultured; Female; Gossypol; Humans; Leukemia; Lymphoma | 2008 |
Gossypol suppresses NF-kappaB activity and NF-kappaB-related gene expression in human leukemia U937 cells.
Topics: Antineoplastic Agents; Apoptosis; Blotting, Western; Cell Proliferation; Dose-Response Relationship, | 2008 |
[Rat basophilic leukemia-1 cell possesses 12-lipoxygenase and 5-lipoxygenase activities which are specifically inhibited by gossypol acetic acid].
Topics: Animals; Arachidonate Lipoxygenases; Basophils; Cells, Cultured; Gossypol; Hydroxyeicosatetraenoic A | 1984 |
Gossypol, a potent inhibitor of arachidonate 5- and 12-lipoxygenases.
Topics: Animals; Arachidonate Lipoxygenases; Arachidonic Acid; Arachidonic Acids; Basophils; Cyclooxygenase | 1985 |