gossypol has been researched along with Kahler Disease in 7 studies
Gossypol: A dimeric sesquiterpene found in cottonseed (GOSSYPIUM). The (-) isomer is active as a male contraceptive (CONTRACEPTIVE AGENTS, MALE) whereas toxic symptoms are associated with the (+) isomer.
| Excerpt | Relevance | Reference |
|---|---|---|
| "This study was aimed to investigate the apoptosis effect of gossypol acetic acid on classic human multiple myeloma RPMI8226 cell line in vitro and its mechanism." | 7.75 | [Apoptosis of multiple myeloma cells induced by gossypol acetic acid in vitro and its mechanism]. ( Bai, QX; Chen, XQ; Huang, GS; Li, R; Wang, JH; Wang, WQ; Wang, Z; Zhang, WP, 2009) |
| "Gossypol is a phenolic aldehyde extracted from plants and is known to be an antitumor agent to induce cancer cell apoptosis." | 5.40 | Proteomic analysis of gossypol induces necrosis in multiple myeloma cells. ( Liu, C; Tang, H; Tian, E; Wang, Q; Xu, R, 2014) |
| "Gossypol (Gos) is a natural polyphenolic compound extracted from cotton plants, and has been shown to possess anti-neoplastic activity against various tumors." | 5.40 | Gossypol induces apoptosis in multiple myeloma cells by inhibition of interleukin-6 signaling and Bcl-2/Mcl-1 pathway. ( Ikeda, Y; Kizaki, M; Nakajima, H; Nakazato, T; Okamoto, S; Sadahira, K; Sagawa, M; Uchida, H, 2014) |
| "Gossypol is a naturally occurring polyphenolic compound extracted from cotton plants." | 5.39 | Induction of apoptosis and antitumor effects of a small molecule inhibitor of Bcl-2 and Bcl-xl, gossypol acetate, in multiple myeloma in vitro and in vivo. ( Lin, J; Wu, Y; Yang, D; Zhao, Y, 2013) |
| "This study was aimed to investigate the apoptosis effect of gossypol acetic acid on classic human multiple myeloma RPMI8226 cell line in vitro and its mechanism." | 3.75 | [Apoptosis of multiple myeloma cells induced by gossypol acetic acid in vitro and its mechanism]. ( Bai, QX; Chen, XQ; Huang, GS; Li, R; Wang, JH; Wang, WQ; Wang, Z; Zhang, WP, 2009) |
| "Gossypol is a phenolic aldehyde extracted from plants and is known to be an antitumor agent to induce cancer cell apoptosis." | 1.40 | Proteomic analysis of gossypol induces necrosis in multiple myeloma cells. ( Liu, C; Tang, H; Tian, E; Wang, Q; Xu, R, 2014) |
| "Gossypol (Gos) is a natural polyphenolic compound extracted from cotton plants, and has been shown to possess anti-neoplastic activity against various tumors." | 1.40 | Gossypol induces apoptosis in multiple myeloma cells by inhibition of interleukin-6 signaling and Bcl-2/Mcl-1 pathway. ( Ikeda, Y; Kizaki, M; Nakajima, H; Nakazato, T; Okamoto, S; Sadahira, K; Sagawa, M; Uchida, H, 2014) |
| "Gossypol is a naturally occurring polyphenolic compound extracted from cotton plants." | 1.39 | Induction of apoptosis and antitumor effects of a small molecule inhibitor of Bcl-2 and Bcl-xl, gossypol acetate, in multiple myeloma in vitro and in vivo. ( Lin, J; Wu, Y; Yang, D; Zhao, Y, 2013) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (14.29) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (28.57) | 29.6817 |
| 2010's | 4 (57.14) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lin, J | 1 |
| Wu, Y | 1 |
| Yang, D | 1 |
| Zhao, Y | 1 |
| Paulus, A | 1 |
| Chitta, K | 1 |
| Akhtar, S | 1 |
| Personett, D | 1 |
| Miller, KC | 1 |
| Thompson, KJ | 1 |
| Carr, J | 1 |
| Kumar, S | 2 |
| Roy, V | 1 |
| Ansell, SM | 1 |
| Mikhael, JR | 1 |
| Dispenzieri, A | 1 |
| Reeder, CB | 1 |
| Rivera, CE | 1 |
| Foran, J | 1 |
| Chanan-Khan, A | 1 |
| Xu, R | 1 |
| Tian, E | 1 |
| Tang, H | 1 |
| Liu, C | 1 |
| Wang, Q | 1 |
| Sadahira, K | 1 |
| Sagawa, M | 1 |
| Nakazato, T | 1 |
| Uchida, H | 1 |
| Ikeda, Y | 1 |
| Okamoto, S | 1 |
| Nakajima, H | 1 |
| Kizaki, M | 1 |
| Wang, WQ | 1 |
| Li, R | 1 |
| Bai, QX | 1 |
| Zhang, WP | 1 |
| Wang, JH | 1 |
| Wang, Z | 1 |
| Chen, XQ | 1 |
| Huang, GS | 1 |
| Kline, MP | 1 |
| Rajkumar, SV | 1 |
| Timm, MM | 1 |
| Kimlinger, TK | 1 |
| Haug, JL | 1 |
| Lust, JA | 1 |
| Greipp, PR | 1 |
| Zhang, JF | 1 |
| Zhang, JB | 1 |
| Yuan, J | 1 |
7 other studies available for gossypol and Kahler Disease
| Article | Year |
|---|---|
Induction of apoptosis and antitumor effects of a small molecule inhibitor of Bcl-2 and Bcl-xl, gossypol acetate, in multiple myeloma in vitro and in vivo.
Topics: Animals; Antineoplastic Agents; Apoptosis; bcl-X Protein; Caspase 3; Caspase 9; Cell Line, Tumor; Ce | 2013 |
AT-101 downregulates BCL2 and MCL1 and potentiates the cytotoxic effects of lenalidomide and dexamethasone in preclinical models of multiple myeloma and Waldenström macroglobulinaemia.
Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Boronic Acids; Bortezomib; Cell Line, Tum | 2014 |
Proteomic analysis of gossypol induces necrosis in multiple myeloma cells.
Topics: Blotting, Western; Cell Line, Tumor; Cell Shape; Electrophoresis, Polyacrylamide Gel; Gossypol; Huma | 2014 |
Gossypol induces apoptosis in multiple myeloma cells by inhibition of interleukin-6 signaling and Bcl-2/Mcl-1 pathway.
Topics: Apoptosis; Cell Line, Tumor; Gene Expression Regulation, Neoplastic; Gossypol; Humans; Interleukin-6 | 2014 |
[Apoptosis of multiple myeloma cells induced by gossypol acetic acid in vitro and its mechanism].
Topics: Apoptosis; bcl-2-Associated X Protein; Caspase 3; Caspase 8; Cell Line, Tumor; Cell Proliferation; G | 2009 |
R-(-)-gossypol (AT-101) activates programmed cell death in multiple myeloma cells.
Topics: Analgesics; Apoptosis; Caspases; Cell Proliferation; Cell Survival; Dexamethasone; Dose-Response Rel | 2008 |
[Experimental studies on the cytotoxic effect of gossypol in mice, rats and human tumor cell lines and its possible mechanism].
Topics: Animals; Antineoplastic Agents, Phytogenic; Cell Line; DNA; Gossypol; HeLa Cells; Humans; Isoenzymes | 1986 |