gossypol has been researched along with Hypospermatogenesis in 9 studies
Gossypol: A dimeric sesquiterpene found in cottonseed (GOSSYPIUM). The (-) isomer is active as a male contraceptive (CONTRACEPTIVE AGENTS, MALE) whereas toxic symptoms are associated with the (+) isomer.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Experiments conducted on Sprague-Dawley rats and cynomolgous monkeys confirm that either (-) or (+) gossypol is too toxic to be developed for human contraception." | 2.40 | Gossypol: reasons for its failure to be accepted as a safe, reversible male antifertility drug. ( Griffin, PD; Waites, GM; Wang, C, 1998) |
| "Gossypol acetic acid was administered orally to 35 male volunteers at a dose of 20 mg once a day for 52-70 days in the loading phase and twice a week for 22 months in the maintenance phase." | 1.28 | Relationship between hormone profiles and the restoration of spermatogenesis in men treated with gossypol. ( Chen, ZX; Gu, ZP; Jiang, Y; Sang, GW; Shao, QX; Wang, WC; Wang, YX; Zhao, XJ, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (33.33) | 18.7374 |
| 1990's | 5 (55.56) | 18.2507 |
| 2000's | 1 (11.11) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Costantino, A | 1 |
| Cerpolini, S | 1 |
| Perrone, AM | 1 |
| Ghi, T | 1 |
| Pelusi, C | 1 |
| Pelusi, G | 1 |
| Meriggiola, MC | 1 |
| Cao, J | 1 |
| Liu, GZ | 1 |
| Lin, T | 1 |
| Murono, EP | 1 |
| Osterman, J | 1 |
| Nankin, HR | 1 |
| Coulson, PB | 1 |
| Yu, ZH | 1 |
| Chan, HC | 1 |
| Waites, GM | 1 |
| Wang, C | 2 |
| Griffin, PD | 1 |
| Udoh, P | 1 |
| Patil, DR | 1 |
| Deshpande, MK | 1 |
| Gu, ZP | 1 |
| Wang, YX | 1 |
| Sang, GW | 1 |
| Wang, WC | 1 |
| Chen, ZX | 1 |
| Zhao, XJ | 1 |
| Shao, QX | 1 |
| Jiang, Y | 1 |
| Lohiya, NK | 1 |
| Sharma, K | 1 |
| Kumar, M | 1 |
| Sharma, S | 1 |
| Meng, GD | 1 |
| Zhu, JC | 1 |
| Chen, ZW | 1 |
| Wong, LT | 1 |
| Zhang, GY | 1 |
| Hu, YZ | 1 |
| Ding, JH | 1 |
| Wang, XH | 1 |
| Qian, SZ | 1 |
3 reviews available for gossypol and Hypospermatogenesis
| Article | Year |
|---|---|
Current status and future perspectives in male contraception.
Topics: Coitus Interruptus; Condoms; Contraception; Contraceptive Agents, Male; Drug Therapy, Combination; F | 2007 |
Gossypol as a male antifertility agent--why studies should have been continued.
Topics: Animals; beta 2-Microglobulin; Contraceptive Agents, Male; Disease Models, Animal; Gossypol; Humans; | 1998 |
Gossypol: reasons for its failure to be accepted as a safe, reversible male antifertility drug.
Topics: Acetates; Animals; Contraceptive Agents, Male; Gossypol; Humans; Hypokalemia; Infertility, Male; Mal | 1998 |
6 other studies available for gossypol and Hypospermatogenesis
| Article | Year |
|---|---|
[Reversibility of azoospermia following gossypol withdrawal].
Topics: Adult; Dose-Response Relationship, Drug; Gossypol; Humans; Male; Middle Aged; Oligospermia; Time Fac | 1983 |
Gossypol inhibits testicular steroidogenesis.
Topics: Animals; Gossypol; Leydig Cells; Male; Mice; Oligospermia; Rats; Testis; Testosterone | 1981 |
Histopathological and biochemical effects of gossypol acetate on pituitary-gonadal axis of male albino rats.
Topics: Acid Phosphatase; Animals; Citrates; Citric Acid; Epididymis; Follicle Stimulating Hormone; Fructose | 1992 |
Relationship between hormone profiles and the restoration of spermatogenesis in men treated with gossypol.
Topics: Administration, Oral; Adult; Double-Blind Method; Estradiol; Follicle Stimulating Hormone; Follow-Up | 1990 |
Limitations in developing gossypol acetic acid as a male contraceptive.
Topics: Administration, Oral; Animals; Body Weight; Cercopithecidae; Contraceptive Agents, Male; Drug Therap | 1990 |
Recovery of sperm production following the cessation of gossypol treatment: a two-centre study in China.
Topics: China; Gossypol; Humans; Kinetics; Male; Oligospermia; Sperm Count; Spermatogenesis; Time Factors | 1988 |