gossypol has been researched along with Hypokalemia in 25 studies
Gossypol: A dimeric sesquiterpene found in cottonseed (GOSSYPIUM). The (-) isomer is active as a male contraceptive (CONTRACEPTIVE AGENTS, MALE) whereas toxic symptoms are associated with the (+) isomer.
Hypokalemia: Abnormally low potassium concentration in the blood. It may result from potassium loss by renal secretion or by the gastrointestinal route, as by vomiting or diarrhea. It may be manifested clinically by neuromuscular disorders ranging from weakness to paralysis, by electrocardiographic abnormalities (depression of the T wave and elevation of the U wave), by renal disease, and by gastrointestinal disorders. (Dorland, 27th ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| "A randomized controlled study was designed to evaluate the merit of whether ingesting potassium salt or potassium (K) blocking agent while using gossypol contraceptive drug could alleviate the symptom of hypokalemia." | 9.06 | Clinical trial of gossypol as a male contraceptive drug. Part II. Hypokalemia study. ( Liu, GZ; Lyle, KC, 1987) |
| "In our earlier study, we have observed that hypokalemia in langur monkeys, following gossypol acetic acid (GAA) treatment (5 mg dose level) when used as an antispermatogenic agent, and potassium salt supplementation partially maintained body potassium level of the animals." | 7.69 | Gossypol-induced hypokalemia and role of exogenous potassium salt supplementation when used as an antispermatogenic agent in male langur monkey. ( Kumar, M; Lohiya, NK; Sharma, S, 1997) |
| "Gossypol was found to be an effective male contraceptive." | 6.66 | Effects of K salt or a potassium blocker on gossypol-related hypokalemia. ( Cao, JA; Ch'iu-Hinton, K; Li, BY; Liu, GZ; Zhu, CX, 1988) |
| "To ascertain whether the side effects of gossypol, hypokalemia and irreversibility, could be avoided on dose reduction." | 5.09 | Low dose gossypol for male contraception. ( Cao, L; Chen, ZX; Gu, ZP; Mao, BY; Segal, SJ; Tan, YZ; Wang, YX; You, GD; Zhang, RA, 2000) |
| "A randomized controlled study was designed to evaluate the merit of whether ingesting potassium salt or potassium (K) blocking agent while using gossypol contraceptive drug could alleviate the symptom of hypokalemia." | 5.06 | Clinical trial of gossypol as a male contraceptive drug. Part II. Hypokalemia study. ( Liu, GZ; Lyle, KC, 1987) |
| "Around 1% of 8806 volunteers taking gossypol as a male contraceptive had hypokalaemic paralysis and more had simple hypokalaemia, the direct cause being renal potassium loss." | 4.77 | Gossypol-hypokalaemia interrelationships. ( Qian, SZ, 1985) |
| "One major side effect of administration of gossypol as a male fertility regulating agent is the occurrence of hypokalaemic paralysis." | 4.77 | Gossypol and hypokalaemia. ( Wang, C; Yeung, RT, 1985) |
| "Gossypol was considered a promising male contraceptive but finally failed due to two side effects: hypokalemia and the irreversibility of its contraceptive effect." | 3.88 | Zero-Order Release of Gossypol Improves Its Antifertility Effect and Reduces Its Side Effects Simultaneously. ( Dong, Y; Guan, Y; Meng, Q; Song, R; Sun, C; Wen, N; Zhang, W; Zhang, Y; Zhuang, X, 2018) |
| "To study the effects of some bioflavonoids on the gossypol-induced hypokalemia." | 3.71 | Inhibition of 11beta-hydroxysteroid dehydrogenase in guinea pig kidney by three bioflavonoids and their interactions with gossypol. ( Reidenberg, MM; Shi, H; Wang, KS; Wang, MS, 2002) |
| "In our earlier study, we have observed that hypokalemia in langur monkeys, following gossypol acetic acid (GAA) treatment (5 mg dose level) when used as an antispermatogenic agent, and potassium salt supplementation partially maintained body potassium level of the animals." | 3.69 | Gossypol-induced hypokalemia and role of exogenous potassium salt supplementation when used as an antispermatogenic agent in male langur monkey. ( Kumar, M; Lohiya, NK; Sharma, S, 1997) |
| "Gossypol was found to be an effective male contraceptive." | 2.66 | Effects of K salt or a potassium blocker on gossypol-related hypokalemia. ( Cao, JA; Ch'iu-Hinton, K; Li, BY; Liu, GZ; Zhu, CX, 1988) |
| " Results showed that the dosage regimen could damage the epididymal sperms and onset of antifertility within 6 weeks in male rats, and prevent the incidence of the side effect of irreversible azoospermia." | 2.41 | [A beam of dawn light of study on gossypol as a safe, effective, and reversible male antifertility contraceptive--evaluation of the studies by using low dose gossypol combined with steroid hormone for male contraception]. ( Xue, S, 2000) |
| " Experiments conducted on Sprague-Dawley rats and cynomolgous monkeys confirm that either (-) or (+) gossypol is too toxic to be developed for human contraception." | 2.40 | Gossypol: reasons for its failure to be accepted as a safe, reversible male antifertility drug. ( Griffin, PD; Waites, GM; Wang, C, 1998) |
| "Gossypol is a yellowish phenolic compound ocurring naturally in certain species of cotton plants of the family Malvaciae, mostly in the seeds and root bark." | 2.37 | Gossypol: a potential antifertility agent for males. ( Qian, SZ; Wang, ZG, 1984) |
| "Gossypol has been proven to be a very effective male contraceptive." | 1.35 | The (+)- and (-)-gossypols potently inhibit human and rat 11beta-hydroxysteroid dehydrogenase type 2. ( Cai, H; Chen, BB; Ge, RS; Gu, DY; Hardy, DO; Hu, GX; Lian, QQ; Lin, H; Su, Y; Zhou, HY, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 13 (52.00) | 18.7374 |
| 1990's | 7 (28.00) | 18.2507 |
| 2000's | 4 (16.00) | 29.6817 |
| 2010's | 1 (4.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Wen, N | 1 |
| Dong, Y | 1 |
| Song, R | 1 |
| Zhang, W | 1 |
| Sun, C | 1 |
| Zhuang, X | 1 |
| Guan, Y | 1 |
| Meng, Q | 1 |
| Zhang, Y | 1 |
| Chen, BB | 1 |
| Lin, H | 1 |
| Hu, GX | 1 |
| Su, Y | 1 |
| Zhou, HY | 1 |
| Lian, QQ | 1 |
| Cai, H | 1 |
| Hardy, DO | 1 |
| Gu, DY | 1 |
| Ge, RS | 1 |
| Xue, S | 1 |
| Qian, SZ | 4 |
| Wang, ZG | 1 |
| Bi, XF | 1 |
| Ye, YX | 1 |
| Yang, HF | 1 |
| Zhang, ZR | 1 |
| Lei, HP | 2 |
| Jing, GW | 1 |
| Wu, XY | 1 |
| Xu, Y | 2 |
| Li, YQ | 1 |
| Zhou, ZH | 1 |
| Fan, LP | 1 |
| Ren, CQ | 1 |
| Hou, TX | 1 |
| Kumar, M | 2 |
| Sharma, S | 2 |
| Lohiya, NK | 2 |
| Yu, ZH | 1 |
| Chan, HC | 1 |
| Waites, GM | 1 |
| Wang, C | 2 |
| Griffin, PD | 1 |
| Michael, AE | 1 |
| Gu, ZP | 1 |
| Mao, BY | 1 |
| Wang, YX | 1 |
| Zhang, RA | 1 |
| Tan, YZ | 1 |
| Chen, ZX | 1 |
| Cao, L | 1 |
| You, GD | 1 |
| Segal, SJ | 1 |
| Wang, MS | 1 |
| Shi, H | 1 |
| Wang, KS | 1 |
| Reidenberg, MM | 2 |
| Chen, ZC | 1 |
| Gao, LM | 1 |
| Sun, SG | 1 |
| Tang, XC | 1 |
| Wang, YE | 1 |
| Shen, LY | 1 |
| Zhu, MK | 1 |
| Sang, GW | 1 |
| Lorenzo, B | 1 |
| Sharma, K | 1 |
| Han, ZY | 1 |
| Liu, GZ | 4 |
| Lyle, KC | 3 |
| Cao, J | 2 |
| Ch'iu-Hinton, K | 1 |
| Cao, JA | 1 |
| Zhu, CX | 2 |
| Li, BY | 2 |
| Yeung, RT | 1 |
6 reviews available for gossypol and Hypokalemia
| Article | Year |
|---|---|
[A beam of dawn light of study on gossypol as a safe, effective, and reversible male antifertility contraceptive--evaluation of the studies by using low dose gossypol combined with steroid hormone for male contraception].
Topics: Animals; Contraceptive Agents, Male; Drug Interactions; Ethinyl Estradiol; Gossypol; Humans; Hypokal | 2000 |
Gossypol: a potential antifertility agent for males.
Topics: Animals; Chemical Phenomena; Chemistry; Chromosome Aberrations; Contraceptive Agents, Male; Embryo, | 1984 |
Gossypol as a male antifertility agent--why studies should have been continued.
Topics: Animals; beta 2-Microglobulin; Contraceptive Agents, Male; Disease Models, Animal; Gossypol; Humans; | 1998 |
Gossypol: reasons for its failure to be accepted as a safe, reversible male antifertility drug.
Topics: Acetates; Animals; Contraceptive Agents, Male; Gossypol; Humans; Hypokalemia; Infertility, Male; Mal | 1998 |
Gossypol-hypokalaemia interrelationships.
Topics: Contraceptive Agents, Male; Gossypol; Humans; Hypokalemia; Male; Paralysis; Potassium | 1985 |
Gossypol and hypokalaemia.
Topics: Animals; Barium; Gossypol; Humans; Hyperaldosteronism; Hyperthyroidism; Hypokalemia; Male; Muscles; | 1985 |
4 trials available for gossypol and Hypokalemia
| Article | Year |
|---|---|
Low dose gossypol for male contraception.
Topics: Contraceptive Agents, Male; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; | 2000 |
Clinical trial of gossypol as a male contraceptive drug. Part II. Hypokalemia study.
Topics: Blood Pressure; Clinical Trials as Topic; Contraceptive Agents, Male; Double-Blind Method; Gossypol; | 1987 |
Experiences with gossypol as a male pill.
Topics: Clinical Trials as Topic; Contraceptive Agents, Male; Gossypol; Humans; Hypokalemia; Male; Potassium | 1987 |
Effects of K salt or a potassium blocker on gossypol-related hypokalemia.
Topics: Analysis of Variance; Contraceptive Agents, Male; Gossypol; Humans; Hypokalemia; Male; Potassium; Sp | 1988 |
15 other studies available for gossypol and Hypokalemia
| Article | Year |
|---|---|
Zero-Order Release of Gossypol Improves Its Antifertility Effect and Reduces Its Side Effects Simultaneously.
Topics: Animals; Contraceptive Agents, Male; Drug Carriers; Drug Implants; Gossypol; Hypokalemia; Male; Rats | 2018 |
The (+)- and (-)-gossypols potently inhibit human and rat 11beta-hydroxysteroid dehydrogenase type 2.
Topics: 11-beta-Hydroxysteroid Dehydrogenase Type 2; 11-beta-Hydroxysteroid Dehydrogenases; Animals; Carbeno | 2009 |
[Preliminary study on gossypol in causing hypokalemia (author's transl)].
Topics: Animals; Gossypol; Guinea Pigs; Humans; Hypokalemia; Male; Potassium; Rats | 1981 |
[Prospect of gossypol as a contraceptive agents for men].
Topics: Animals; Contraceptive Agents, Male; Gossypol; Humans; Hypokalemia; Liver; Male; Rats; Testis | 1983 |
Gossypol related hypokalemia. Clinicopharmacologic studies.
Topics: Contraceptive Agents, Male; Gossypol; Humans; Hypokalemia; Kidney; Male; Paralysis; Potassium; Saliv | 1980 |
[Review and prospect of gossypol research (author's transl)].
Topics: Animals; Contraceptive Agents, Male; Gossypol; Humans; Hypokalemia; Male; Rats; Sexual Behavior | 1982 |
[Emergency treatment and care of hypokalemia paralysis due to gossypol poisoning].
Topics: Emergencies; Gossypol; Humans; Hypokalemia; Infusions, Intravenous; Paralysis; Potassium | 1995 |
Gossypol-induced hypokalemia and role of exogenous potassium salt supplementation when used as an antispermatogenic agent in male langur monkey.
Topics: Animals; Antispermatogenic Agents; Cercopithecidae; Cohort Studies; Gossypol; Hypokalemia; Male; Pot | 1997 |
11 beta HSD and the mechanism of gossypol-induced hypokalemia.
Topics: 11-beta-Hydroxysteroid Dehydrogenases; Corticosterone; Gossypol; Hydroxysteroid Dehydrogenases; Hypo | 1998 |
Inhibition of 11beta-hydroxysteroid dehydrogenase in guinea pig kidney by three bioflavonoids and their interactions with gossypol.
Topics: 11-beta-Hydroxysteroid Dehydrogenase Type 1; Animals; Depression, Chemical; Drug Synergism; Enzyme I | 2002 |
[The influence of gossypol on the potassium metabolism of rats and the effect of some possible contributing factors (low-K and low-MG intake) (author's transl)].
Topics: Animals; Gossypol; Hypokalemia; Magnesium; Male; Muscles; Potassium; Rats | 1979 |
Inhibitory effects of gossypol on corticosteroid 11-beta-hydroxysteroid dehydrogenase from guinea pig kidney: a possible mechanism for causing hypokalemia.
Topics: 11-beta-Hydroxysteroid Dehydrogenases; Animals; Gossypol; Guinea Pigs; Hydroxysteroid Dehydrogenases | 1991 |
Limitations in developing gossypol acetic acid as a male contraceptive.
Topics: Administration, Oral; Animals; Body Weight; Cercopithecidae; Contraceptive Agents, Male; Drug Therap | 1990 |
[Relationship between eating cotton-seed oil and blood potassium levels].
Topics: Cottonseed Oil; Female; Gossypol; Humans; Hypokalemia; Male; Potassium | 1988 |
Effect of K salt and K sparing agent in preventing gossypol-induced hypokalemia.
Topics: Gonadal Steroid Hormones; Gossypol; Humans; Hypokalemia; Male; Potassium | 1987 |