gossypol has been researched along with Huntington Disease in 2 studies
Gossypol: A dimeric sesquiterpene found in cottonseed (GOSSYPIUM). The (-) isomer is active as a male contraceptive (CONTRACEPTIVE AGENTS, MALE) whereas toxic symptoms are associated with the (+) isomer.
Huntington Disease: A familial disorder inherited as an autosomal dominant trait and characterized by the onset of progressive CHOREA and DEMENTIA in the fourth or fifth decade of life. Common initial manifestations include paranoia; poor impulse control; DEPRESSION; HALLUCINATIONS; and DELUSIONS. Eventually intellectual impairment; loss of fine motor control; ATHETOSIS; and diffuse chorea involving axial and limb musculature develops, leading to a vegetative state within 10-15 years of disease onset. The juvenile variant has a more fulminant course including SEIZURES; ATAXIA; dementia; and chorea. (From Adams et al., Principles of Neurology, 6th ed, pp1060-4)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (50.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (50.00) | 2.80 |
| Authors | Studies |
|---|---|
| Li, XJ | 1 |
| Zhang, YY | 1 |
| Fu, YH | 1 |
| Zhang, H | 1 |
| Li, HX | 1 |
| Li, QF | 1 |
| Li, HL | 1 |
| Tan, RK | 1 |
| Jiang, CX | 1 |
| Jiang, W | 1 |
| Li, ZX | 1 |
| Luo, C | 1 |
| Lu, BX | 1 |
| Dang, YJ | 1 |
| Heiser, V | 1 |
| Scherzinger, E | 1 |
| Boeddrich, A | 1 |
| Nordhoff, E | 1 |
| Lurz, R | 1 |
| Schugardt, N | 1 |
| Lehrach, H | 1 |
| Wanker, EE | 1 |
2 other studies available for gossypol and Huntington Disease
| Article | Year |
|---|---|
Gossypol, a novel modulator of VCP, induces autophagic degradation of mutant huntingtin by promoting the formation of VCP/p97-LC3-mHTT complex.
Topics: Animals; Autophagy; Drosophila; Enzyme Inhibitors; Female; Gossypol; HEK293 Cells; HeLa Cells; Human | 2021 |
Inhibition of huntingtin fibrillogenesis by specific antibodies and small molecules: implications for Huntington's disease therapy.
Topics: Animals; Antibodies, Monoclonal; Benzoates; Benzothiazoles; Biphenyl Compounds; Congo Red; COS Cells | 2000 |