gossypol has been researched along with Hormone-Dependent Neoplasms in 4 studies
Gossypol: A dimeric sesquiterpene found in cottonseed (GOSSYPIUM). The (-) isomer is active as a male contraceptive (CONTRACEPTIVE AGENTS, MALE) whereas toxic symptoms are associated with the (+) isomer.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Gossypol is a polyphenolic aldehyde occurring naturally in cottonseed that produces antisteroidogenic activity in vivo, has been extensively investigated as a male contraceptive agent, and has demonstrated anticancer activity." | 5.29 | Antiproliferative activity of gossypol and gossypolone on human breast cancer cells. ( Brueggemeier, RW; Chang, CJ; Gilbert, NE; Lin, YC; O'Reilly, JE, 1995) |
| "Further investigation of AT-101 in prostate cancer is warranted and trials combining AT-101 with androgen deprivation, as well as with docetaxel chemotherapy are ongoing." | 2.74 | An open-label, multicenter, phase I/II study of single-agent AT-101 in men with castrate-resistant prostate cancer. ( Brill, K; Kelly, WK; Leopold, L; Liu, G; Somer, B; Wilding, G, 2009) |
| "Gossypol is a polyphenolic aldehyde occurring naturally in cottonseed that produces antisteroidogenic activity in vivo, has been extensively investigated as a male contraceptive agent, and has demonstrated anticancer activity." | 1.29 | Antiproliferative activity of gossypol and gossypolone on human breast cancer cells. ( Brueggemeier, RW; Chang, CJ; Gilbert, NE; Lin, YC; O'Reilly, JE, 1995) |
| "Gossypol-treated rats exhibited weight reductions in developed MAT-LyLu prostate tumor mass and prostate of 24% (p < 0." | 1.29 | Antiproliferative and antimetastatic effects of gossypol on Dunning prostate cell-bearing Copenhagen rats. ( Brueggemeier, RW; Chang, CJ; Ghosh, PK; Hu, YF; Lin, YC, 1993) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (50.00) | 18.2507 |
| 2000's | 2 (50.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Liu, G | 1 |
| Kelly, WK | 1 |
| Wilding, G | 1 |
| Leopold, L | 1 |
| Brill, K | 1 |
| Somer, B | 1 |
| Brozic, P | 1 |
| Lanisnik Risner, T | 1 |
| Gobec, S | 1 |
| Gilbert, NE | 1 |
| O'Reilly, JE | 1 |
| Chang, CJ | 2 |
| Lin, YC | 2 |
| Brueggemeier, RW | 2 |
| Ghosh, PK | 1 |
| Hu, YF | 1 |
1 review available for gossypol and Hormone-Dependent Neoplasms
| Article | Year |
|---|---|
Inhibitors of 17beta-hydroxysteroid dehydrogenase type 1.
Topics: 17-Hydroxysteroid Dehydrogenases; Breast Neoplasms; Enzyme Inhibitors; Estradiol; Estrogens; Estrone | 2008 |
1 trial available for gossypol and Hormone-Dependent Neoplasms
| Article | Year |
|---|---|
An open-label, multicenter, phase I/II study of single-agent AT-101 in men with castrate-resistant prostate cancer.
Topics: Adenocarcinoma; Administration, Oral; Aged; Aged, 80 and over; Antineoplastic Agents, Phytogenic; Co | 2009 |
2 other studies available for gossypol and Hormone-Dependent Neoplasms
| Article | Year |
|---|---|
Antiproliferative activity of gossypol and gossypolone on human breast cancer cells.
Topics: Antineoplastic Agents; Breast Neoplasms; Cell Division; Drug Resistance, Multiple; Drug Screening As | 1995 |
Antiproliferative and antimetastatic effects of gossypol on Dunning prostate cell-bearing Copenhagen rats.
Topics: Androgens; Animals; Antineoplastic Agents; Cell Division; Genitalia, Male; Gossypol; Lung Neoplasms; | 1993 |