gossypol has been researched along with Glial Cell Tumors in 6 studies
Gossypol: A dimeric sesquiterpene found in cottonseed (GOSSYPIUM). The (-) isomer is active as a male contraceptive (CONTRACEPTIVE AGENTS, MALE) whereas toxic symptoms are associated with the (+) isomer.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The present study evaluates the effects of AT101, alone or in combination with temozolomide (TMZ), in a microenvironmental glioma stem cell niche model of two GBM cell lines (U251MG and U87MG)." | 4.02 | Effects of the Anti-Tumorigenic Agent AT101 on Human Glioblastoma Cells in the Microenvironmental Glioma Stem Cell Niche. ( Caylioglu, D; Held-Feindt, J; Hellmold, D; Kubelt, C; Meyer, RJ; Synowitz, M, 2021) |
| " AT 101 ([-]-gossypol), a natural compound from cotton seeds, induces ACD in glioma cells as confirmed here by CRISPR/Cas9 knockout of ATG5 that partially, but significantly rescued cell survival following AT 101 treatment." | 3.88 | AT 101 induces early mitochondrial dysfunction and HMOX1 (heme oxygenase 1) to trigger mitophagic cell death in glioma cells. ( Behrends, C; Fulda, S; Kögel, D; Linder, B; Meyer, N; Michaelis, JB; Mittelbronn, M; Münch, C; Osiewacz, HD; Rakel, S; Warnsmann, V; Zielke, S, 2018) |
| "Gossypol is a lipid soluble polyphenolic compound isolated from cotton seed oil which has been previously shown to have antiproliferative activity in vitro against a variety of human solid tumor cell lines." | 1.29 | In vitro and in vivo cytotoxicity of gossypol against central nervous system tumor cell lines. ( Coyle, T; Levante, S; Shetler, M; Winfield, J, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (33.33) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 3 (50.00) | 24.3611 |
| 2020's | 1 (16.67) | 2.80 |
| Authors | Studies |
|---|---|
| Caylioglu, D | 1 |
| Meyer, RJ | 1 |
| Hellmold, D | 1 |
| Kubelt, C | 1 |
| Synowitz, M | 1 |
| Held-Feindt, J | 1 |
| Meyer, N | 1 |
| Zielke, S | 1 |
| Michaelis, JB | 1 |
| Linder, B | 2 |
| Warnsmann, V | 1 |
| Rakel, S | 1 |
| Osiewacz, HD | 1 |
| Fulda, S | 2 |
| Mittelbronn, M | 2 |
| Münch, C | 1 |
| Behrends, C | 1 |
| Kögel, D | 3 |
| Antonietti, P | 1 |
| Hehlgans, S | 1 |
| Mildenberger, IC | 1 |
| Burger, MC | 1 |
| Steinbach, JP | 2 |
| Gessler, F | 1 |
| Rödel, F | 1 |
| Voss, V | 1 |
| Senft, C | 1 |
| Lang, V | 1 |
| Ronellenfitsch, MW | 1 |
| Seifert, V | 1 |
| Coyle, T | 2 |
| Levante, S | 1 |
| Shetler, M | 1 |
| Winfield, J | 2 |
| Bushunow, P | 1 |
| Reidenberg, MM | 1 |
| Wasenko, J | 1 |
| Lorenzo, B | 1 |
| Lemke, S | 1 |
| Himpler, B | 1 |
| Corona, R | 1 |
6 other studies available for gossypol and Glial Cell Tumors
| Article | Year |
|---|---|
Effects of the Anti-Tumorigenic Agent AT101 on Human Glioblastoma Cells in the Microenvironmental Glioma Stem Cell Niche.
Topics: Antineoplastic Combined Chemotherapy Protocols; Brain; Brain Neoplasms; Carcinogenesis; Cell Line, T | 2021 |
AT 101 induces early mitochondrial dysfunction and HMOX1 (heme oxygenase 1) to trigger mitophagic cell death in glioma cells.
Topics: Autophagy; Autophagy-Related Protein 5; Cell Line, Tumor; Glioma; Gossypol; Heme Oxygenase-1; Humans | 2018 |
Interference with the HSF1/HSP70/BAG3 Pathway Primes Glioma Cells to Matrix Detachment and BH3 Mimetic-Induced Apoptosis.
Topics: Adaptor Proteins, Signal Transducing; Animals; Apoptosis; Apoptosis Regulatory Proteins; bcl-X Prote | 2017 |
The pan-Bcl-2 inhibitor (-)-gossypol triggers autophagic cell death in malignant glioma.
Topics: Animals; Apoptosis; Autophagy; Caspases; Cell Line, Tumor; Dacarbazine; DNA Modification Methylases; | 2010 |
In vitro and in vivo cytotoxicity of gossypol against central nervous system tumor cell lines.
Topics: Animals; Antineoplastic Agents; Cell Line; Cell Survival; Central Nervous System Neoplasms; Glioma; | 1994 |
Gossypol treatment of recurrent adult malignant gliomas.
Topics: Adult; Aged; Brain Neoplasms; Disease-Free Survival; Female; Glioma; Gossypol; Humans; Male; Middle | 1999 |