gossypol has been researched along with Disease Models, Animal in 19 studies
Gossypol: A dimeric sesquiterpene found in cottonseed (GOSSYPIUM). The (-) isomer is active as a male contraceptive (CONTRACEPTIVE AGENTS, MALE) whereas toxic symptoms are associated with the (+) isomer.
Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We observed that gossypol inhibited expression of both MDM2 and VEGF in human breast cancer cells with either wild-type or mutant p53." | 7.85 | Gossypol has anti-cancer effects by dual-targeting MDM2 and VEGF in human breast cancer. ( Li, J; Su, T; Wang, J; Xiong, J; Yang, Q; Zhou, S, 2017) |
| "The results indicate that gossypol induces pancreatitis through an activation of polyamine catabolism." | 7.72 | Gossypol activates pancreatic polyamine catabolism in normal rats and induces acute pancreatitis in transgenic rats over-expressing spermidine/spermine N1-acetyltransferase. ( Alhonen, L; Herzig, KH; Jänne, J; Kaasinen, K; Keinänen, T; Räsänen, TL; Sinervirta, R; Uimari, A, 2003) |
| "Gossypol is a polyphenol from the cotton plant with anti-inflammatory and anti-oxidation activities and can also function as a histone deacetylase (HDAC) inhibitor." | 5.91 | Gossypol improves myocardial dysfunction caused by sepsis by regulating histone acetylation. ( Lv, X; Shi, X; Xiao, D, 2023) |
| "This study investigated the effect of gossypol on hyperplastic canine prostates induced with long-term administration of androgen and estrogen." | 5.29 | Experimentally-induced prostatic hyperplasia in young beagles: a model to evaluate the chemotherapeutic effects of gossypol. ( Brueggemeier, RW; Canatan, H; Chang, CJ; Chang, WY; Kulp, SK; Lin, YC; Shidaifat, F; Sugimoto, Y, 1996) |
| "We observed that gossypol inhibited expression of both MDM2 and VEGF in human breast cancer cells with either wild-type or mutant p53." | 3.85 | Gossypol has anti-cancer effects by dual-targeting MDM2 and VEGF in human breast cancer. ( Li, J; Su, T; Wang, J; Xiong, J; Yang, Q; Zhou, S, 2017) |
| "The results indicate that gossypol induces pancreatitis through an activation of polyamine catabolism." | 3.72 | Gossypol activates pancreatic polyamine catabolism in normal rats and induces acute pancreatitis in transgenic rats over-expressing spermidine/spermine N1-acetyltransferase. ( Alhonen, L; Herzig, KH; Jänne, J; Kaasinen, K; Keinänen, T; Räsänen, TL; Sinervirta, R; Uimari, A, 2003) |
| "Gastro-oesophageal cancers (GEC) are resistant to therapy and lead to poor prognosis." | 3.01 | Targeting cancer stem cells with a pan-BCL-2 inhibitor in preclinical and clinical settings in patients with gastroesophageal carcinoma. ( Ajani, JA; Bhutani, M; Chen, Q; Correa, A; Estrella, JS; Gan, B; Hofstetter, WL; Huo, L; Jin, J; Johnson, RL; Lee, JH; Lei, G; Li, CY; Li, Y; Liu, B; Ma, L; Pizzi, MP; Scott, A; Shanbhag, N; Song, S; Wang, Y; Wei, S; Weston, B; Xiao, L, 2021) |
| "Gossypol is a polyphenol from the cotton plant with anti-inflammatory and anti-oxidation activities and can also function as a histone deacetylase (HDAC) inhibitor." | 1.91 | Gossypol improves myocardial dysfunction caused by sepsis by regulating histone acetylation. ( Lv, X; Shi, X; Xiao, D, 2023) |
| "Gossypol is a natural polyphenolic compound with anti-inflammation, anti-oxidant, and anticancer activities." | 1.62 | Gossypol Reduces Metastasis and Epithelial-Mesenchymal Transition by Targeting Protease in Human Cervical Cancer. ( Chen, PN; Chu, SC; Hsieh, YS; Huang, SC; Kao, SH; Lin, MS, 2021) |
| "Osteoporosis is one of the most frequent diseases related with age." | 1.51 | Gossypol Promotes Wnt/ ( Chen, C; Hu, J; Liang, J; Liu, H; Liu, X; Zhao, H, 2019) |
| "This study investigated the effect of gossypol on hyperplastic canine prostates induced with long-term administration of androgen and estrogen." | 1.29 | Experimentally-induced prostatic hyperplasia in young beagles: a model to evaluate the chemotherapeutic effects of gossypol. ( Brueggemeier, RW; Canatan, H; Chang, CJ; Chang, WY; Kulp, SK; Lin, YC; Shidaifat, F; Sugimoto, Y, 1996) |
| " Our data suggest that both the route of drug administration and dosing regimen employed affect the antiinflammatory potency and/or efficacy of compounds on colitis induced by acetic acid in the rat." | 1.28 | Antiinflammatory effects of various drugs on acetic acid induced colitis in the rat. ( Bostwick, JS; Decktor, DL; Fitzpatrick, LR; Pendleton, RG; Renzetti, M, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (5.26) | 18.7374 |
| 1990's | 3 (15.79) | 18.2507 |
| 2000's | 4 (21.05) | 29.6817 |
| 2010's | 6 (31.58) | 24.3611 |
| 2020's | 5 (26.32) | 2.80 |
| Authors | Studies |
|---|---|
| Solinski, HJ | 1 |
| Dranchak, P | 1 |
| Oliphant, E | 1 |
| Gu, X | 1 |
| Earnest, TW | 1 |
| Braisted, J | 1 |
| Inglese, J | 1 |
| Hoon, MA | 1 |
| Abrams, RPM | 1 |
| Yasgar, A | 1 |
| Teramoto, T | 1 |
| Lee, MH | 1 |
| Dorjsuren, D | 1 |
| Eastman, RT | 1 |
| Malik, N | 1 |
| Zakharov, AV | 1 |
| Li, W | 1 |
| Bachani, M | 1 |
| Brimacombe, K | 1 |
| Steiner, JP | 1 |
| Hall, MD | 1 |
| Balasubramanian, A | 1 |
| Jadhav, A | 1 |
| Padmanabhan, R | 1 |
| Simeonov, A | 1 |
| Nath, A | 1 |
| Shi, X | 1 |
| Lv, X | 1 |
| Xiao, D | 1 |
| Zhu, X | 1 |
| Wu, Y | 1 |
| Pan, J | 1 |
| Li, C | 1 |
| Huang, J | 1 |
| Cui, E | 1 |
| Chen, Z | 1 |
| Zhou, W | 1 |
| Chai, X | 1 |
| Zhao, S | 1 |
| Hsieh, YS | 1 |
| Chu, SC | 1 |
| Huang, SC | 1 |
| Kao, SH | 1 |
| Lin, MS | 1 |
| Chen, PN | 1 |
| Song, S | 1 |
| Chen, Q | 1 |
| Li, Y | 1 |
| Lei, G | 1 |
| Scott, A | 1 |
| Huo, L | 1 |
| Li, CY | 1 |
| Estrella, JS | 1 |
| Correa, A | 1 |
| Pizzi, MP | 1 |
| Ma, L | 1 |
| Jin, J | 1 |
| Liu, B | 1 |
| Wang, Y | 1 |
| Xiao, L | 1 |
| Hofstetter, WL | 1 |
| Lee, JH | 1 |
| Weston, B | 1 |
| Bhutani, M | 1 |
| Shanbhag, N | 1 |
| Johnson, RL | 1 |
| Gan, B | 1 |
| Wei, S | 1 |
| Ajani, JA | 1 |
| Liang, J | 1 |
| Chen, C | 1 |
| Liu, H | 1 |
| Liu, X | 1 |
| Zhao, H | 1 |
| Hu, J | 1 |
| Zhang, X | 1 |
| Hu, X | 1 |
| Mu, S | 1 |
| Zhan, Y | 1 |
| An, Q | 1 |
| Liu, Z | 1 |
| Huang, X | 1 |
| Xiong, J | 1 |
| Li, J | 1 |
| Yang, Q | 1 |
| Wang, J | 1 |
| Su, T | 1 |
| Zhou, S | 1 |
| Semon, B | 1 |
| Huo, M | 1 |
| Gao, R | 1 |
| Jiang, L | 1 |
| Cui, X | 1 |
| Duan, L | 1 |
| Deng, X | 1 |
| Guan, S | 1 |
| Wei, J | 1 |
| Soromou, LW | 1 |
| Feng, H | 1 |
| Chi, G | 1 |
| Räsänen, TL | 1 |
| Alhonen, L | 1 |
| Sinervirta, R | 1 |
| Uimari, A | 1 |
| Kaasinen, K | 1 |
| Keinänen, T | 1 |
| Herzig, KH | 1 |
| Jänne, J | 1 |
| Susman, E | 1 |
| Paoluzzi, L | 1 |
| Gonen, M | 1 |
| Gardner, JR | 1 |
| Mastrella, J | 1 |
| Yang, D | 1 |
| Holmlund, J | 1 |
| Sorensen, M | 1 |
| Leopold, L | 1 |
| Manova, K | 1 |
| Marcucci, G | 1 |
| Heaney, ML | 1 |
| O'Connor, OA | 1 |
| Chang, WY | 1 |
| Shidaifat, F | 1 |
| Chang, CJ | 1 |
| Kulp, SK | 1 |
| Sugimoto, Y | 1 |
| Canatan, H | 1 |
| Brueggemeier, RW | 1 |
| Lin, YC | 1 |
| Yu, ZH | 1 |
| Chan, HC | 1 |
| Abe, Y | 1 |
| Itoh, K | 1 |
| Arakawa, Y | 1 |
| Fitzpatrick, LR | 1 |
| Bostwick, JS | 1 |
| Renzetti, M | 1 |
| Pendleton, RG | 1 |
| Decktor, DL | 1 |
| Vichkanova, SA | 1 |
| Oĭfa, AI | 1 |
| Goriunova, LV | 1 |
1 review available for gossypol and Disease Models, Animal
| Article | Year |
|---|---|
Gossypol as a male antifertility agent--why studies should have been continued.
Topics: Animals; beta 2-Microglobulin; Contraceptive Agents, Male; Disease Models, Animal; Gossypol; Humans; | 1998 |
1 trial available for gossypol and Disease Models, Animal
| Article | Year |
|---|---|
Targeting cancer stem cells with a pan-BCL-2 inhibitor in preclinical and clinical settings in patients with gastroesophageal carcinoma.
Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Cell Line, Tumor; Disease Models, Animal; Doc | 2021 |
17 other studies available for gossypol and Disease Models, Animal
| Article | Year |
|---|---|
Inhibition of natriuretic peptide receptor 1 reduces itch in mice.
Topics: Animals; Behavior, Animal; Cell-Free System; Dermatitis, Contact; Disease Models, Animal; Ganglia, S | 2019 |
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Dr | 2020 |
Gossypol improves myocardial dysfunction caused by sepsis by regulating histone acetylation.
Topics: Acetylation; Animals; Cytokines; Disease Models, Animal; Gossypol; Histones; Lipopolysaccharides; Mi | 2023 |
Neuroinflammation Induction and Alteration of Hippocampal Neurogenesis in Mice Following Developmental Exposure to Gossypol.
Topics: Animals; Animals, Newborn; Behavior, Animal; Cognitive Dysfunction; Disease Models, Animal; Endocrin | 2021 |
Gossypol Reduces Metastasis and Epithelial-Mesenchymal Transition by Targeting Protease in Human Cervical Cancer.
Topics: Animals; Antineoplastic Agents, Phytogenic; Cell Movement; Disease Models, Animal; Epithelial-Mesenc | 2021 |
Gossypol Promotes Wnt/
Topics: Adaptor Proteins, Signal Transducing; Animals; Apoptosis; Cell Line; Cell Proliferation; Disease Mod | 2019 |
Apogossypolone inhibits the proliferation of LNCaP cells in vitro and in vivo.
Topics: Adenine; Animals; Antineoplastic Agents; Apoptosis; Apoptosis Regulatory Proteins; Autophagy; bcl-2 | 2014 |
Gossypol has anti-cancer effects by dual-targeting MDM2 and VEGF in human breast cancer.
Topics: 3' Untranslated Regions; Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Breast Neoplasms; Ce | 2017 |
Dietary intake of cottonseed toxins is hypothesized to be a partial cause of Alzheimer's disorder.
Topics: Aged; Alzheimer Disease; Animals; Cell Membrane Permeability; Cholesterol; Cottonseed Oil; Disease M | 2012 |
Suppression of LPS-induced inflammatory responses by gossypol in RAW 264.7 cells and mouse models.
Topics: Animals; Cell Line; Cytokines; Disease Models, Animal; Gossypium; Gossypol; Humans; Inflammation Med | 2013 |
Gossypol activates pancreatic polyamine catabolism in normal rats and induces acute pancreatitis in transgenic rats over-expressing spermidine/spermine N1-acetyltransferase.
Topics: Acetyltransferases; Acute Disease; Animals; Animals, Genetically Modified; Contraceptive Agents, Mal | 2003 |
Cottonseed-oil byproduct as anticancer radiation sensitiser.
Topics: Animals; Combined Modality Therapy; Cottonseed Oil; Disease Models, Animal; Gossypol; Humans; Male; | 2004 |
Targeting Bcl-2 family members with the BH3 mimetic AT-101 markedly enhances the therapeutic effects of chemotherapeutic agents in in vitro and in vivo models of B-cell lymphoma.
Topics: Animals; Antibodies, Monoclonal; Antibodies, Monoclonal, Murine-Derived; Antineoplastic Agents, Phyt | 2008 |
Experimentally-induced prostatic hyperplasia in young beagles: a model to evaluate the chemotherapeutic effects of gossypol.
Topics: 5-alpha Reductase Inhibitors; Acute Disease; Animals; Aromatase Inhibitors; Disease Models, Animal; | 1996 |
Altered vascular response to acetylcholine in conditions of endothelial damage in the isolated perfused rat stomach.
Topics: Acetylcholine; Animals; Blood Flow Velocity; Cyclic GMP; Disease Models, Animal; Endothelium, Vascul | 2000 |
Antiinflammatory effects of various drugs on acetic acid induced colitis in the rat.
Topics: Acetates; Acetic Acid; Aminosalicylic Acids; Animals; Anti-Inflammatory Agents; Colitis, Ulcerative; | 1990 |
[Antiviral properties of gossypol in experimental influenza pneumonia].
Topics: Animals; Depression, Chemical; Disease Models, Animal; Gossypol; Mice; Orthomyxoviridae; Pneumonia, | 1970 |