gossypol has been researched along with Cell Transformation, Neoplastic in 3 studies
Gossypol: A dimeric sesquiterpene found in cottonseed (GOSSYPIUM). The (-) isomer is active as a male contraceptive (CONTRACEPTIVE AGENTS, MALE) whereas toxic symptoms are associated with the (+) isomer.
Cell Transformation, Neoplastic: Cell changes manifested by escape from control mechanisms, increased growth potential, alterations in the cell surface, karyotypic abnormalities, morphological and biochemical deviations from the norm, and other attributes conferring the ability to invade, metastasize, and kill.
| Excerpt | Relevance | Reference |
|---|---|---|
| "It is suggested that obese individuals may be at greater risk of developing zeranol-induced breast cancer." | 7.75 | Mitogenic activity of zeranol in human breast cancer cells is enhanced by leptin and suppressed by gossypol. ( Jen, R; Kuo, CT; Lin, SH; Lin, YC; Xu, P; Ye, W, 2009) |
| "It is suggested that obese individuals may be at greater risk of developing zeranol-induced breast cancer." | 3.75 | Mitogenic activity of zeranol in human breast cancer cells is enhanced by leptin and suppressed by gossypol. ( Jen, R; Kuo, CT; Lin, SH; Lin, YC; Xu, P; Ye, W, 2009) |
| "Cutaneous malignant melanoma is among the deadliest human cancers, broadly resistant to most clinical therapies." | 1.43 | Integrated Genomics Identifies miR-32/MCL-1 Pathway as a Critical Driver of Melanomagenesis: Implications for miR-Replacement and Combination Therapy. ( Merlino, G; Mishra, PJ, 2016) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (33.33) | 29.6817 |
| 2010's | 2 (66.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Mishra, PJ | 2 |
| Merlino, G | 1 |
| Xu, P | 1 |
| Ye, W | 1 |
| Jen, R | 1 |
| Lin, SH | 1 |
| Kuo, CT | 1 |
| Lin, YC | 1 |
| Jackson, RS | 1 |
| Placzek, W | 1 |
| Fernandez, A | 1 |
| Ziaee, S | 1 |
| Chu, CY | 1 |
| Wei, J | 1 |
| Stebbins, J | 1 |
| Kitada, S | 1 |
| Fritz, G | 1 |
| Reed, JC | 1 |
| Chung, LW | 1 |
| Pellecchia, M | 1 |
| Bhowmick, NA | 1 |
3 other studies available for gossypol and Cell Transformation, Neoplastic
| Article | Year |
|---|---|
Integrated Genomics Identifies miR-32/MCL-1 Pathway as a Critical Driver of Melanomagenesis: Implications for miR-Replacement and Combination Therapy.
Topics: Animals; Carcinogenesis; Cell Line, Tumor; Cell Transformation, Neoplastic; Drug Synergism; Drug The | 2016 |
Mitogenic activity of zeranol in human breast cancer cells is enhanced by leptin and suppressed by gossypol.
Topics: Anticarcinogenic Agents; Breast Neoplasms; Cell Growth Processes; Cell Line, Tumor; Cell Transformat | 2009 |
Sabutoclax, a Mcl-1 antagonist, inhibits tumorigenesis in transgenic mouse and human xenograft models of prostate cancer.
Topics: Animals; Antineoplastic Agents; Apoptosis; Bone Neoplasms; Cell Transformation, Neoplastic; Disease | 2012 |