gossypol has been researched along with Cancer of Stomach in 8 studies
Gossypol: A dimeric sesquiterpene found in cottonseed (GOSSYPIUM). The (-) isomer is active as a male contraceptive (CONTRACEPTIVE AGENTS, MALE) whereas toxic symptoms are associated with the (+) isomer.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The present study has evaluated the chemopreventive effects of gossypol on N-methyl-N'-nitro-N-nitrosoguanidine (MNNG)-induced gastric carcinogenesis and on human gastric adenocarcinoma (AGS) cell line." | 7.77 | In vitro and in vivo studies on antitumor effects of gossypol on human stomach adenocarcinoma (AGS) cell line and MNNG induced experimental gastric cancer. ( Gayathri, R; Gunassekaran, GR; Priya, DK; Sakthisekaran, D, 2011) |
| "The present study has evaluated the chemopreventive effects of gossypol on N-methyl-N'-nitro-N-nitrosoguanidine (MNNG)-induced gastric carcinogenesis and on human gastric adenocarcinoma (AGS) cell line." | 3.77 | In vitro and in vivo studies on antitumor effects of gossypol on human stomach adenocarcinoma (AGS) cell line and MNNG induced experimental gastric cancer. ( Gayathri, R; Gunassekaran, GR; Priya, DK; Sakthisekaran, D, 2011) |
| "Gastro-oesophageal cancers (GEC) are resistant to therapy and lead to poor prognosis." | 3.01 | Targeting cancer stem cells with a pan-BCL-2 inhibitor in preclinical and clinical settings in patients with gastroesophageal carcinoma. ( Ajani, JA; Bhutani, M; Chen, Q; Correa, A; Estrella, JS; Gan, B; Hofstetter, WL; Huo, L; Jin, J; Johnson, RL; Lee, JH; Lei, G; Li, CY; Li, Y; Liu, B; Ma, L; Pizzi, MP; Scott, A; Shanbhag, N; Song, S; Wang, Y; Wei, S; Weston, B; Xiao, L, 2021) |
| "Here, we examined energy metabolism in gastric cancer cells and found increased fatty acid oxidation and increased expression of ALDH3A1." | 1.51 | Gastric cancer depends on aldehyde dehydrogenase 3A1 for fatty acid oxidation. ( Cheong, JH; Kang, JH; Kim, SH; Kim, SY; Lee, JS; Lee, S; Lee, SH, 2019) |
| "Gastric cancer is one of the most common types of malignancies and proteins from the Bcl-2 family are highly expressed in human gastric cancer." | 1.39 | ApoG2 as the most potent gossypol derivatives inhibits cell growth and induces apoptosis on gastric cancer cells. ( Liang, JM; Nie, YZ; Tian, J; Xia, LM; Xin, J; Zhan, YH; Zhu, HW, 2013) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (12.50) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 5 (62.50) | 24.3611 |
| 2020's | 2 (25.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lee, JS | 1 |
| Kim, SH | 1 |
| Lee, S | 1 |
| Kang, JH | 1 |
| Lee, SH | 1 |
| Cheong, JH | 1 |
| Kim, SY | 1 |
| Liu, Y | 1 |
| Ma, Y | 1 |
| Li, Z | 1 |
| Yang, Y | 1 |
| Yu, B | 1 |
| Zhang, Z | 1 |
| Wang, G | 1 |
| Song, S | 1 |
| Chen, Q | 1 |
| Li, Y | 2 |
| Lei, G | 1 |
| Scott, A | 1 |
| Huo, L | 1 |
| Li, CY | 1 |
| Estrella, JS | 1 |
| Correa, A | 1 |
| Pizzi, MP | 1 |
| Ma, L | 1 |
| Jin, J | 1 |
| Liu, B | 1 |
| Wang, Y | 1 |
| Xiao, L | 1 |
| Hofstetter, WL | 1 |
| Lee, JH | 1 |
| Weston, B | 1 |
| Bhutani, M | 1 |
| Shanbhag, N | 1 |
| Johnson, RL | 1 |
| Gan, B | 1 |
| Wei, S | 1 |
| Ajani, JA | 1 |
| Xin, J | 2 |
| Zhan, Y | 1 |
| Liu, M | 1 |
| Hu, H | 1 |
| Xia, L | 1 |
| Nie, Y | 1 |
| Wu, K | 1 |
| Liang, J | 1 |
| Tian, J | 2 |
| Wei, X | 1 |
| Duan, W | 1 |
| Zhang, S | 1 |
| Xin, X | 1 |
| Sun, L | 1 |
| Gao, M | 1 |
| Li, Q | 1 |
| Wang, D | 1 |
| Gunassekaran, GR | 1 |
| Priya, DK | 1 |
| Gayathri, R | 1 |
| Sakthisekaran, D | 1 |
| Zhan, YH | 1 |
| Xia, LM | 1 |
| Zhu, HW | 1 |
| Nie, YZ | 1 |
| Liang, JM | 1 |
| VERMEL, EM | 1 |
1 trial available for gossypol and Cancer of Stomach
| Article | Year |
|---|---|
Targeting cancer stem cells with a pan-BCL-2 inhibitor in preclinical and clinical settings in patients with gastroesophageal carcinoma.
Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Cell Line, Tumor; Disease Models, Animal; Doc | 2021 |
7 other studies available for gossypol and Cancer of Stomach
| Article | Year |
|---|---|
Gastric cancer depends on aldehyde dehydrogenase 3A1 for fatty acid oxidation.
Topics: Adenosine Triphosphate; Aldehyde Dehydrogenase; Animals; Cell Line, Tumor; Cell Proliferation; Fatty | 2019 |
Investigation of Inhibition Effect of Gossypol-Acetic Acid on Gastric Cancer Cells Based on a Network Pharmacology Approach and Experimental Validation.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Cell Cycle Checkpoints; Cell Proliferation; Drug Scree | 2020 |
ApoG2 induces ER stress-dependent apoptosis in gastric cancer cells in vitro and its real-time evaluation by bioluminescence imaging in vivo.
Topics: Animals; Apoptosis; Calcium; Cell Line, Tumor; Cell Survival; Endoplasmic Reticulum Stress; Female; | 2013 |
AT101 exerts a synergetic efficacy in gastric cancer patients with 5-FU based treatment through promoting apoptosis and autophagy.
Topics: AC133 Antigen; Adult; Aged; Aged, 80 and over; Animals; Antineoplastic Agents; Apoptosis; Autophagy; | 2016 |
In vitro and in vivo studies on antitumor effects of gossypol on human stomach adenocarcinoma (AGS) cell line and MNNG induced experimental gastric cancer.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Cell Survival; | 2011 |
ApoG2 as the most potent gossypol derivatives inhibits cell growth and induces apoptosis on gastric cancer cells.
Topics: Antineoplastic Agents; Apoptosis; bcl-2-Associated X Protein; Blotting, Western; Caspase 3; Cell Lin | 2013 |
THE SEARCH FOR ANTITUMOUR SUBSTANCES OF PLANT ORIGIN.
Topics: Animals; Antineoplastic Agents; Carcinoma, Ehrlich Tumor; Coumarins; Gossypol; Melanoma; Mice; Neopl | 1964 |