gossypol has been researched along with Cancer of Pancreas in 9 studies
Gossypol: A dimeric sesquiterpene found in cottonseed (GOSSYPIUM). The (-) isomer is active as a male contraceptive (CONTRACEPTIVE AGENTS, MALE) whereas toxic symptoms are associated with the (+) isomer.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Improved treatments for pancreatic cancer remain a clinical imperative." | 1.42 | Pancreatic Cancer Combination Therapy Using a BH3 Mimetic and a Synthetic Tetracycline. ( Azab, B; Bhoopathi, P; Das, SK; Dash, R; Emdad, L; Fisher, PB; Pellecchia, M; Quinn, BA; Sarkar, D; Sarkar, S; Wei, J, 2015) |
| "Apogossypolone (ApoG2) is an analogue of (-)-gossypol, exhibiting binding activity with Ki values of 35 nmol/L for Bcl-2 and 25 nmol/L for Mcl-1." | 1.36 | Preclinical studies of apogossypolone, a novel pan inhibitor of bcl-2 and mcl-1, synergistically potentiates cytotoxic effect of gemcitabine in pancreatic cancer cells. ( Aboukameel, A; Banerjee, S; Chen, J; Choi, M; Mohammad, M; Mohammad, RM; Sarkar, FH; Wang, Z; Yang, D, 2010) |
| "(-)-Gossypol was dissolved in DMSO at 20 mmol/L as stock solution, and genistein was dissolved in 0." | 1.33 | Nonpeptidic small-molecule inhibitor of Bcl-2 and Bcl-XL, (-)-Gossypol, enhances biological effect of genistein against BxPC-3 human pancreatic cancer cell line. ( Banerjee, S; Chen, J; Mohammad, RM; Sarkar, FH; Wang, S; Wu, X, 2005) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (11.11) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (22.22) | 29.6817 |
| 2010's | 4 (44.44) | 24.3611 |
| 2020's | 2 (22.22) | 2.80 |
| Authors | Studies |
|---|---|
| Lee, S | 1 |
| Hong, E | 1 |
| Jo, E | 1 |
| Kim, ZH | 1 |
| Yim, KJ | 1 |
| Woo, SH | 1 |
| Choi, YS | 1 |
| Jang, HJ | 1 |
| Lee, JS | 1 |
| Lee, H | 1 |
| Woo, SM | 1 |
| Jang, H | 1 |
| Jeon, Y | 1 |
| Kim, HY | 1 |
| Song, J | 1 |
| Lee, WJ | 1 |
| Hong, EK | 1 |
| Park, SJ | 1 |
| Han, SS | 1 |
| Kim, SY | 1 |
| Cao, H | 1 |
| Sethumadhavan, K | 1 |
| Bland, JM | 1 |
| Yuan, Y | 1 |
| Tang, AJ | 1 |
| Castoreno, AB | 1 |
| Kuo, SY | 1 |
| Wang, Q | 1 |
| Kuballa, P | 1 |
| Xavier, R | 1 |
| Shamji, AF | 1 |
| Schreiber, SL | 1 |
| Wagner, BK | 1 |
| Quinn, BA | 1 |
| Dash, R | 1 |
| Sarkar, S | 1 |
| Azab, B | 1 |
| Bhoopathi, P | 1 |
| Das, SK | 1 |
| Emdad, L | 1 |
| Wei, J | 1 |
| Pellecchia, M | 1 |
| Sarkar, D | 1 |
| Fisher, PB | 1 |
| Banerjee, S | 2 |
| Choi, M | 1 |
| Aboukameel, A | 1 |
| Wang, Z | 1 |
| Mohammad, M | 1 |
| Chen, J | 2 |
| Yang, D | 1 |
| Sarkar, FH | 2 |
| Mohammad, RM | 2 |
| Wang, S | 1 |
| Wu, X | 1 |
| Song, JJ | 1 |
| An, JY | 1 |
| Kwon, YT | 1 |
| Lee, YJ | 1 |
| Benz, C | 1 |
| Keniry, M | 1 |
| Goldberg, H | 1 |
9 other studies available for gossypol and Cancer of Pancreas
| Article | Year |
|---|---|
Gossypol Induces Apoptosis of Human Pancreatic Cancer Cells via CHOP/Endoplasmic Reticulum Stress Signaling Pathway.
Topics: Apoptosis; Endoplasmic Reticulum Stress; Gossypol; Humans; Pancreatic Neoplasms; Signal Transduction | 2022 |
Overall survival of pancreatic ductal adenocarcinoma is doubled by
Topics: Aldehyde Dehydrogenase; Aldehydes; Animals; Carcinoma, Pancreatic Ductal; Cell Line, Tumor; Cell Mov | 2021 |
Overall survival of pancreatic ductal adenocarcinoma is doubled by
Topics: Aldehyde Dehydrogenase; Aldehydes; Animals; Carcinoma, Pancreatic Ductal; Cell Line, Tumor; Cell Mov | 2021 |
Overall survival of pancreatic ductal adenocarcinoma is doubled by
Topics: Aldehyde Dehydrogenase; Aldehydes; Animals; Carcinoma, Pancreatic Ductal; Cell Line, Tumor; Cell Mov | 2021 |
Overall survival of pancreatic ductal adenocarcinoma is doubled by
Topics: Aldehyde Dehydrogenase; Aldehydes; Animals; Carcinoma, Pancreatic Ductal; Cell Line, Tumor; Cell Mov | 2021 |
Isolation of Cottonseed Extracts That Affect Human Cancer Cell Growth.
Topics: Antineoplastic Agents; Breast Neoplasms; Cell Survival; Cottonseed Oil; Gossypol; Humans; Mitochondr | 2018 |
Gossypol and an HMT G9a inhibitor act in synergy to induce cell death in pancreatic cancer cells.
Topics: Antineoplastic Agents; Autophagy; Benzamides; Benzimidazoles; Cell Line, Tumor; Drug Resistance, Neo | 2013 |
Pancreatic Cancer Combination Therapy Using a BH3 Mimetic and a Synthetic Tetracycline.
Topics: Animals; Apoptosis; Cell Line, Tumor; Drug Synergism; Gene Expression Regulation, Neoplastic; Gossyp | 2015 |
Preclinical studies of apogossypolone, a novel pan inhibitor of bcl-2 and mcl-1, synergistically potentiates cytotoxic effect of gemcitabine in pancreatic cancer cells.
Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Apoptosis | 2010 |
Nonpeptidic small-molecule inhibitor of Bcl-2 and Bcl-XL, (-)-Gossypol, enhances biological effect of genistein against BxPC-3 human pancreatic cancer cell line.
Topics: Apoptosis; bcl-X Protein; Cell Line, Tumor; Cytochromes c; Drug Synergism; Genistein; Gossypol; Huma | 2005 |
Evidence for two modes of development of acquired tumor necrosis factor-related apoptosis-inducing ligand resistance. Involvement of Bcl-xL.
Topics: Apoptosis; bcl-Associated Death Protein; bcl-X Protein; Cell Line, Tumor; Cell Survival; Gene Expres | 2007 |
Selective toxicity of gossypol against epithelial tumors and its detection by magnetic resonance spectroscopy.
Topics: Animals; Bone Marrow; Epithelium; Gossypol; Humans; Isoenzymes; L-Lactate Dehydrogenase; Liver Neopl | 1988 |