gossypol has been researched along with Cancer of Ovary in 9 studies
Gossypol: A dimeric sesquiterpene found in cottonseed (GOSSYPIUM). The (-) isomer is active as a male contraceptive (CONTRACEPTIVE AGENTS, MALE) whereas toxic symptoms are associated with the (+) isomer.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Effects of the gossypol on endometriosis in 12 cases of control were observed." | 7.67 | [Clinical effects and experimental study on gossypol in endometriosis]. ( Wang, M; Xu, LF; Zhao, CL, 1989) |
| "Effects of the gossypol on endometriosis in 12 cases of control were observed." | 3.67 | [Clinical effects and experimental study on gossypol in endometriosis]. ( Wang, M; Xu, LF; Zhao, CL, 1989) |
| "Upon gossypol treatment, changes in phosphorylation of twenty-nine proteins including YAP1 and AKAP12 were characterized." | 1.40 | Phosphoproteomic analysis of gossypol-induced apoptosis in ovarian cancer cell line, HOC1a. ( Chen, Y; Deng, H; Ge, R; Jin, L; Lian, Q; Mu, X, 2014) |
| "Gossypol treatment resulted in cell death through oxidative stress." | 1.39 | Gossypol induces apoptosis in ovarian cancer cells through oxidative stress. ( Chen, Y; Deng, H; Ge, R; Jin, L; Li, X; Lian, Q; Wang, J, 2013) |
| "Current treatment strategies for ovarian cancer focus on novel drug combinations of cytotoxic agents and molecular targeted agents or novel drug delivery strategies that often involve intraperitoneal (IP) injection." | 1.39 | Poly(ethylene glycol)-block-poly(ε-caprolactone) micelles for combination drug delivery: evaluation of paclitaxel, cyclopamine and gossypol in intraperitoneal xenograft models of ovarian cancer. ( Cho, H; Kwon, GS; Lai, TC, 2013) |
| "Chemoresistance of ovarian cancer has been previously attributed to the expression and activation of Bcl-2 family proteins." | 1.38 | Proapoptotic protein Smac mediates apoptosis in cisplatin-resistant ovarian cancer cells when treated with the anti-tumor agent AT101. ( Hu, W; Liu, X; Nie, C; Tang, J; Wang, F; Wei, Y; Yuan, Z, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (11.11) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (11.11) | 29.6817 |
| 2010's | 6 (66.67) | 24.3611 |
| 2020's | 1 (11.11) | 2.80 |
| Authors | Studies |
|---|---|
| Li, C | 1 |
| Song, Y | 1 |
| Li, P | 1 |
| Wang, J | 1 |
| Jin, L | 2 |
| Li, X | 1 |
| Deng, H | 3 |
| Chen, Y | 2 |
| Lian, Q | 2 |
| Ge, R | 2 |
| Cho, H | 2 |
| Cho, CS | 1 |
| Indig, GL | 1 |
| Lavasanifar, A | 1 |
| Vakili, MR | 1 |
| Kwon, GS | 2 |
| Mu, X | 1 |
| Atmaca, H | 2 |
| Gorumlu, G | 1 |
| Karaca, B | 2 |
| Degirmenci, M | 1 |
| Tunali, D | 1 |
| Cirak, Y | 1 |
| Purcu, DU | 1 |
| Uzunoglu, S | 2 |
| Karabulut, B | 2 |
| Sanli, UA | 2 |
| Uslu, R | 2 |
| Hu, W | 1 |
| Wang, F | 1 |
| Tang, J | 1 |
| Liu, X | 1 |
| Yuan, Z | 1 |
| Nie, C | 1 |
| Wei, Y | 1 |
| Lai, TC | 1 |
| Bozkurt, E | 1 |
| Kisim, A | 1 |
| Sezgin, C | 1 |
| Xu, LF | 1 |
| Wang, M | 1 |
| Zhao, CL | 1 |
9 other studies available for gossypol and Cancer of Ovary
| Article | Year |
|---|---|
MCL1 regulates cell death, tumor growth and chemosensitivity to sabutoclax in ovarian adenocarcinoma.
Topics: Adenocarcinoma; Animals; Cell Death; Cell Line, Tumor; Cell Proliferation; Drug Resistance, Neoplasm | 2020 |
Gossypol induces apoptosis in ovarian cancer cells through oxidative stress.
Topics: Apoptosis; Aspartic Acid; Carrier Proteins; Cell Line, Tumor; Chaperonin 60; Contraceptive Agents, M | 2013 |
Polymeric micelles for apoptosis-targeted optical imaging of cancer and intraoperative surgical guidance.
Topics: Animals; Antineoplastic Agents; Apoptosis; Female; Fluorescent Dyes; Gossypol; Humans; In Situ Nick- | 2014 |
Phosphoproteomic analysis of gossypol-induced apoptosis in ovarian cancer cell line, HOC1a.
Topics: Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Female; Gossypol; Humans; Neoplasm Proteins; Ova | 2014 |
Combined gossypol and zoledronic acid treatment results in synergistic induction of cell death and regulates angiogenic molecules in ovarian cancer cells.
Topics: Angiogenesis Inducing Agents; Caspase 3; Caspase 7; Cell Death; Cell Line, Tumor; Cell Proliferation | 2009 |
Proapoptotic protein Smac mediates apoptosis in cisplatin-resistant ovarian cancer cells when treated with the anti-tumor agent AT101.
Topics: Antineoplastic Agents; Apoptosis; Apoptosis Regulatory Proteins; bcl-2-Associated X Protein; Caspase | 2012 |
Poly(ethylene glycol)-block-poly(ε-caprolactone) micelles for combination drug delivery: evaluation of paclitaxel, cyclopamine and gossypol in intraperitoneal xenograft models of ovarian cancer.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Line, Tumor; Cell Survival; Drug Carri | 2013 |
Combination of AT-101/cisplatin overcomes chemoresistance by inducing apoptosis and modulating epigenetics in human ovarian cancer cells.
Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Caspase 3; Caspase 7; Cell Line, Tumor; C | 2013 |
[Clinical effects and experimental study on gossypol in endometriosis].
Topics: Adult; Antineoplastic Agents, Phytogenic; Drugs, Chinese Herbal; Endometriosis; Female; Gossypol; Hu | 1989 |