gossypol has been researched along with Cancer of Lung in 20 studies
Gossypol: A dimeric sesquiterpene found in cottonseed (GOSSYPIUM). The (-) isomer is active as a male contraceptive (CONTRACEPTIVE AGENTS, MALE) whereas toxic symptoms are associated with the (+) isomer.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Unlike trials with continuous daily dosing of AT-101, no cases of small bowel obstruction were reported." | 2.76 | Double-blind, placebo-controlled, randomized phase 2 study of the proapoptotic agent AT-101 plus docetaxel, in second-line non-small cell lung cancer. ( Holmlund, JT; Karaseva, NA; Leopold, L; Luft, AV; Orlov, SV; Popovych, O; Ready, N; Wood, BA, 2011) |
| "Gossypol was sufficient to reduce the invasion, migration and adhesion in DLD-1 and COLO 205 cells." | 1.51 | Antimetastatic effects of gossypol on colon cancer cells by targeting the u-PA and FAK pathways. ( Chen, PN; Chu, SC; Hsieh, YS; Hsu, LS; Huang, SF; Tu, YC, 2019) |
| "Malignant melanoma has shown increased incidence and high mortality rate in the last three decades." | 1.48 | Combination therapy with BH3 mimetic and hyperthermia tends to be more effective on anti-melanoma treatment. ( Guo, F; Lan, B; Li, X; Peng, B; Shi, Z; Wang, X; Zhang, G, 2018) |
| "Radiotherapy has a central role in the treatment of lung cancer." | 1.36 | AT-101, a pan-Bcl-2 inhibitor, leads to radiosensitization of non-small cell lung cancer. ( Chen, H; Kim, KW; Li, B; Lu, B; Moretti, L, 2010) |
| " The objective of this study was to evaluate the effect of various SPI, both alone and in combination with cisplatin, on three different non-small cell lung cancer (NSCLC) cell lines." | 1.35 | Efficacy of signal pathway inhibitors alone and in combination with Cisplatin varies between human non-small cell lung cancer lines. ( El-Hefnawy, T; Kilic, A; Landreneau, RJ; Luketich, JD; Schuchert, MJ, 2009) |
| "Acquisition of metastatic ability by prostatic cancer cells is the most lethal aspect of prostatic cancer progression." | 1.35 | (-)-Gossypol reduces invasiveness in metastatic prostate cancer cells. ( Dowd, MK; Huang, YW; Lin, YC; Wan, PJ; Wang, LS, 2009) |
| "Gossypol has wide antineoplastic effects in vitro, but its effects on human lung cancer have not been explored." | 1.32 | Upregulation of Fas/Fas ligand-mediated apoptosis by gossypol in an immortalized human alveolar lung cancer cell line. ( Chang, JS; Chiang, LC; Hsu, YL; Kuo, PL; Lin, CC, 2004) |
| "Gossypol-treated rats exhibited weight reductions in developed MAT-LyLu prostate tumor mass and prostate of 24% (p < 0." | 1.29 | Antiproliferative and antimetastatic effects of gossypol on Dunning prostate cell-bearing Copenhagen rats. ( Brueggemeier, RW; Chang, CJ; Ghosh, PK; Hu, YF; Lin, YC, 1993) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (5.00) | 18.7374 |
| 1990's | 1 (5.00) | 18.2507 |
| 2000's | 5 (25.00) | 29.6817 |
| 2010's | 13 (65.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Huang, SF | 1 |
| Chu, SC | 1 |
| Hsu, LS | 1 |
| Tu, YC | 1 |
| Chen, PN | 1 |
| Hsieh, YS | 1 |
| Shi, Z | 1 |
| Lan, B | 1 |
| Peng, B | 1 |
| Wang, X | 1 |
| Zhang, G | 1 |
| Li, X | 1 |
| Guo, F | 1 |
| Mei, H | 1 |
| Lin, Z | 1 |
| Wang, Y | 1 |
| Wu, G | 1 |
| Song, Y | 1 |
| Ren, T | 2 |
| Shan, J | 2 |
| Qing, Y | 2 |
| Qian, C | 2 |
| Li, Q | 3 |
| Lu, G | 2 |
| Li, M | 2 |
| Li, C | 2 |
| Peng, Y | 2 |
| Luo, H | 2 |
| Zhang, S | 3 |
| Zhang, W | 1 |
| Wang, D | 3 |
| Zhou, SF | 2 |
| Wang, G | 1 |
| Yang, Y | 1 |
| Cheng, Y | 1 |
| Wei, X | 1 |
| Li, Y | 1 |
| Duan, W | 1 |
| Huang, C | 1 |
| Zheng, X | 1 |
| Sun, L | 1 |
| Luo, J | 1 |
| Xin, X | 1 |
| Gao, M | 1 |
| Kang, JH | 1 |
| Lee, SH | 1 |
| Lee, JS | 1 |
| Nam, B | 1 |
| Seong, TW | 1 |
| Son, J | 1 |
| Jang, H | 1 |
| Hong, KM | 1 |
| Lee, C | 1 |
| Kim, SY | 1 |
| Zhao, R | 1 |
| Zhou, S | 1 |
| Xia, B | 1 |
| Zhang, CY | 1 |
| Hai, P | 1 |
| Zhe, H | 1 |
| Wang, YY | 1 |
| Kilic, A | 1 |
| Schuchert, MJ | 1 |
| Luketich, JD | 1 |
| Landreneau, RJ | 1 |
| El-Hefnawy, T | 1 |
| Wei, J | 1 |
| Kitada, S | 1 |
| Rega, MF | 1 |
| Emdadi, A | 1 |
| Yuan, H | 1 |
| Cellitti, J | 1 |
| Stebbins, JL | 1 |
| Zhai, D | 1 |
| Sun, J | 1 |
| Yang, L | 1 |
| Dahl, R | 1 |
| Zhang, Z | 1 |
| Wu, B | 1 |
| Wang, S | 1 |
| Reed, TA | 1 |
| Wang, HG | 1 |
| Lawrence, N | 1 |
| Sebti, S | 1 |
| Reed, JC | 1 |
| Pellecchia, M | 1 |
| Huang, YW | 1 |
| Wang, LS | 1 |
| Dowd, MK | 1 |
| Wan, PJ | 1 |
| Lin, YC | 2 |
| Moretti, L | 1 |
| Li, B | 1 |
| Kim, KW | 1 |
| Chen, H | 1 |
| Lu, B | 1 |
| Heist, RS | 1 |
| Fain, J | 1 |
| Chinnasami, B | 1 |
| Khan, W | 1 |
| Molina, JR | 1 |
| Sequist, LV | 1 |
| Temel, JS | 1 |
| Fidias, P | 1 |
| Brainerd, V | 1 |
| Leopold, L | 2 |
| Lynch, TJ | 1 |
| Zwitter, M | 1 |
| Ready, N | 1 |
| Karaseva, NA | 1 |
| Orlov, SV | 1 |
| Luft, AV | 1 |
| Popovych, O | 1 |
| Holmlund, JT | 1 |
| Wood, BA | 1 |
| Baggstrom, MQ | 1 |
| Qi, Y | 1 |
| Koczywas, M | 1 |
| Argiris, A | 1 |
| Johnson, EA | 1 |
| Millward, MJ | 1 |
| Murphy, SC | 1 |
| Erlichman, C | 1 |
| Rudin, CM | 1 |
| Govindan, R | 1 |
| Chang, JS | 1 |
| Hsu, YL | 1 |
| Kuo, PL | 1 |
| Chiang, LC | 1 |
| Lin, CC | 1 |
| Yeow, WS | 1 |
| Baras, A | 1 |
| Chua, A | 1 |
| Nguyen, DM | 2 |
| Sehgal, SS | 1 |
| Schrump, DS | 1 |
| Chang, CJ | 1 |
| Ghosh, PK | 1 |
| Hu, YF | 1 |
| Brueggemeier, RW | 1 |
| Pirogov, AI | 1 |
| Maksimov, IA | 1 |
| Os'makov, NA | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Randomized, Double Blind, Placebo-controlled Multiple-center Phase III Trial of Gossypol Combined With Docetaxel and Cisplatin Scheme in Advanced Non Small-cell Lung Cancers With APE1 High Expression[NCT01977209] | Phase 3 | 204 participants (Anticipated) | Interventional | 2013-09-30 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 trials available for gossypol and Cancer of Lung
| Article | Year |
|---|---|
Phase I/II study of AT-101 with topotecan in relapsed and refractory small cell lung cancer.
Topics: Adenocarcinoma; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Cohort Studies; Drug Re | 2010 |
Double-blind, placebo-controlled, randomized phase 2 study of the proapoptotic agent AT-101 plus docetaxel, in second-line non-small cell lung cancer.
Topics: Adenocarcinoma; Adenocarcinoma, Bronchiolo-Alveolar; Aged; Antineoplastic Combined Chemotherapy Prot | 2011 |
A phase II study of AT-101 (Gossypol) in chemotherapy-sensitive recurrent extensive-stage small cell lung cancer.
Topics: Aged; Contraceptive Agents, Male; Drug Resistance, Neoplasm; Female; Follow-Up Studies; Gossypol; Hu | 2011 |
17 other studies available for gossypol and Cancer of Lung
| Article | Year |
|---|---|
Antimetastatic effects of gossypol on colon cancer cells by targeting the u-PA and FAK pathways.
Topics: Animals; Cadherins; Cell Line, Tumor; Cell Movement; Cell Survival; Colonic Neoplasms; Epithelial-Me | 2019 |
Combination therapy with BH3 mimetic and hyperthermia tends to be more effective on anti-melanoma treatment.
Topics: Animals; Apoptosis; BH3 Interacting Domain Death Agonist Protein; Biomimetics; Cell Line, Tumor; Cel | 2018 |
Autophagy inhibition enhances pan-Bcl-2 inhibitor AT-101-induced apoptosis in non-small cell lung cancer.
Topics: Apoptosis; Autophagy; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Drug Resistance, Neoplasm; G | 2014 |
Sequential treatment with AT-101 enhances cisplatin chemosensitivity in human non-small cell lung cancer cells through inhibition of apurinic/apyrimidinic endonuclease 1-activated IL-6/STAT3 signaling pathway.
Topics: Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Non-Small-Cell Lung; Cell Proliferation; | 2014 |
Small-molecule BH3 mimetic and pan-Bcl-2 inhibitor AT-101 enhances the antitumor efficacy of cisplatin through inhibition of APE1 repair and redox activity in non-small-cell lung cancer.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Carcinoma, Non-Small-Cell Lung; | 2015 |
Prediction of survival prognosis of non-small cell lung cancer by APE1 through regulation of Epithelial-Mesenchymal Transition.
Topics: A549 Cells; Animals; Antineoplastic Agents, Phytogenic; Carcinoma, Non-Small-Cell Lung; Cell Line, T | 2016 |
Aldehyde dehydrogenase inhibition combined with phenformin treatment reversed NSCLC through ATP depletion.
Topics: Action Potentials; Adenosine Triphosphate; Aldehyde Dehydrogenase; Animals; Aspartic Acid; Carcinoma | 2016 |
AT-101 enhances gefitinib sensitivity in non-small cell lung cancer with EGFR T790M mutations.
Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; bcl-X Protein; Carcinoma, Non-Small-Cell Lung | 2016 |
Efficacy of signal pathway inhibitors alone and in combination with Cisplatin varies between human non-small cell lung cancer lines.
Topics: Carcinoma, Non-Small-Cell Lung; Celecoxib; Cell Line, Tumor; Chromones; Cisplatin; Cyclooxygenase In | 2009 |
Apogossypol derivatives as antagonists of antiapoptotic Bcl-2 family proteins.
Topics: Animals; Apoptosis Regulatory Proteins; bcl-2 Homologous Antagonist-Killer Protein; bcl-2-Associated | 2009 |
(-)-Gossypol reduces invasiveness in metastatic prostate cancer cells.
Topics: Animals; Apoptosis; bcl-X Protein; Blotting, Western; Cell Movement; Cell Proliferation; Contracepti | 2009 |
AT-101, a pan-Bcl-2 inhibitor, leads to radiosensitization of non-small cell lung cancer.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Carcinoma, Non-Small-Cell Lung; Cell Proliferation; Ga | 2010 |
Combining cytotoxic and targeted therapies for lung cancer.
Topics: Antineoplastic Combined Chemotherapy Protocols; Clinical Trials as Topic; Gossypol; Humans; Lung Neo | 2010 |
Upregulation of Fas/Fas ligand-mediated apoptosis by gossypol in an immortalized human alveolar lung cancer cell line.
Topics: Apoptosis; Carcinoma, Non-Small-Cell Lung; Caspase 8; Caspases; Cell Cycle Proteins; Cell Line, Tumo | 2004 |
Gossypol, a phytochemical with BH3-mimetic property, sensitizes cultured thoracic cancer cells to Apo2 ligand/tumor necrosis factor-related apoptosis-inducing ligand.
Topics: Apoptosis; Carcinoma, Non-Small-Cell Lung; Cell Death; Esophageal Neoplasms; Gossypol; Humans; Lung | 2006 |
Antiproliferative and antimetastatic effects of gossypol on Dunning prostate cell-bearing Copenhagen rats.
Topics: Androgens; Animals; Antineoplastic Agents; Cell Division; Genitalia, Male; Gossypol; Lung Neoplasms; | 1993 |
[Postoperative bronchopleural complications in the combined treatment of lung cancer].
Topics: Adult; Antineoplastic Agents; Bronchial Fistula; Cyclophosphamide; Dose-Response Relationship, Radia | 1974 |