gossypol has been researched along with Cancer of Colon in 12 studies
Gossypol: A dimeric sesquiterpene found in cottonseed (GOSSYPIUM). The (-) isomer is active as a male contraceptive (CONTRACEPTIVE AGENTS, MALE) whereas toxic symptoms are associated with the (+) isomer.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In this study, human colon cancer cells (COLO 225) were treated with gossypol." | 1.62 | Gossypol decreased cell viability and down-regulated the expression of a number of genes in human colon cancer cells. ( Cao, F; Cao, H; Sethumadhavan, K; Wang, TTY, 2021) |
| "Gossypol was sufficient to reduce the invasion, migration and adhesion in DLD-1 and COLO 205 cells." | 1.51 | Antimetastatic effects of gossypol on colon cancer cells by targeting the u-PA and FAK pathways. ( Chen, PN; Chu, SC; Hsieh, YS; Hsu, LS; Huang, SF; Tu, YC, 2019) |
| "Our data suggest that PEGylation improved the bioavailability of Gn as well as achieved tumor-targeted delivery and controlled release of Gn, which enhanced its overall biocompatibility and drug efficacy in vivo." | 1.48 | Natural product derivative Gossypolone inhibits Musashi family of RNA-binding proteins. ( Appelman, C; Aubé, J; De Guzman, RN; Gao, P; Gowthaman, R; Karanicolas, J; Lan, L; Larsen, S; Liu, FY; Liu, H; Marquez, RT; Neufeld, KL; Rogers, S; Smith, AR; Wu, X; Xu, L; Yu, J, 2018) |
| "Gossypol is a polyphenolic extract of cottonseeds." | 1.42 | Gossypol sensitizes the antitumor activity of 5-FU through down-regulation of thymidylate synthase in human colon carcinoma cells. ( Cao, Y; Feng, W; Hou, K; Liu, Y; Qu, J; Qu, X; Xu, L; Yang, D, 2015) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (8.33) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (16.67) | 29.6817 |
| 2010's | 7 (58.33) | 24.3611 |
| 2020's | 2 (16.67) | 2.80 |
| Authors | Studies |
|---|---|
| Yan, F | 1 |
| Cao, XX | 1 |
| Jiang, HX | 1 |
| Zhao, XL | 1 |
| Wang, JY | 1 |
| Lin, YH | 1 |
| Liu, QL | 1 |
| Zhang, C | 1 |
| Jiang, B | 1 |
| Guo, F | 1 |
| Cao, H | 2 |
| Sethumadhavan, K | 2 |
| Huang, SF | 1 |
| Chu, SC | 1 |
| Hsu, LS | 1 |
| Tu, YC | 1 |
| Chen, PN | 1 |
| Hsieh, YS | 1 |
| Cao, F | 1 |
| Wang, TTY | 1 |
| Lan, L | 2 |
| Liu, H | 3 |
| Smith, AR | 2 |
| Appelman, C | 2 |
| Yu, J | 2 |
| Larsen, S | 2 |
| Marquez, RT | 2 |
| Wu, X | 3 |
| Liu, FY | 1 |
| Gao, P | 2 |
| Gowthaman, R | 2 |
| Karanicolas, J | 2 |
| De Guzman, RN | 2 |
| Rogers, S | 2 |
| Aubé, J | 2 |
| Neufeld, KL | 2 |
| Xu, L | 3 |
| Roy, A | 1 |
| Anbanandam, A | 1 |
| Ji, M | 1 |
| Cohen, RS | 1 |
| Wang, J | 2 |
| Peng, Y | 1 |
| Liu, Y | 3 |
| Yang, J | 1 |
| Huang, M | 1 |
| Tan, W | 1 |
| Yang, D | 2 |
| Qu, J | 1 |
| Qu, X | 1 |
| Cao, Y | 1 |
| Hou, K | 1 |
| Feng, W | 1 |
| Sung, B | 1 |
| Ravindran, J | 1 |
| Prasad, S | 1 |
| Pandey, MK | 1 |
| Aggarwal, BB | 1 |
| Zhang, M | 1 |
| Guo, R | 1 |
| Ling, Y | 1 |
| Li, B | 1 |
| Roller, PP | 1 |
| Wang, S | 1 |
| Tuszynski, GP | 1 |
| Cossu, G | 1 |
| Wang, X | 1 |
| Wong, SC | 1 |
| Chow, LS | 1 |
| Nicholls, JM | 1 |
| Wong, YC | 1 |
| Kwong, DL | 1 |
| Sham, JS | 1 |
| Tsa, SW | 1 |
12 other studies available for gossypol and Cancer of Colon
| Article | Year |
|---|---|
A novel water-soluble gossypol derivative increases chemotherapeutic sensitivity and promotes growth inhibition in colon cancer.
Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Proliferation; Cell Survival; Colo | 2010 |
Identification of
Topics: Animals; Bacteria; Colonic Neoplasms; Cottonseed Oil; Gossypol; Humans; Lipopolysaccharides; Mammals | 2022 |
Antimetastatic effects of gossypol on colon cancer cells by targeting the u-PA and FAK pathways.
Topics: Animals; Cadherins; Cell Line, Tumor; Cell Movement; Cell Survival; Colonic Neoplasms; Epithelial-Me | 2019 |
Gossypol decreased cell viability and down-regulated the expression of a number of genes in human colon cancer cells.
Topics: Biomarkers; Biomarkers, Tumor; Cell Line, Tumor; Cell Survival; Colonic Neoplasms; Cottonseed Oil; D | 2021 |
Natural product derivative Gossypolone inhibits Musashi family of RNA-binding proteins.
Topics: Animals; Apoptosis; Biological Products; Cell Line, Tumor; Colonic Neoplasms; Gene Expression Regula | 2018 |
Natural product (-)-gossypol inhibits colon cancer cell growth by targeting RNA-binding protein Musashi-1.
Topics: Animals; Cell Line; Cell Line, Tumor; Cell Proliferation; Colonic Neoplasms; Female; Gossypol; Human | 2015 |
AT-101 inhibits hedgehog pathway activity and cancer growth.
Topics: Animals; Antineoplastic Agents, Phytogenic; Cell Line, Tumor; Cell Proliferation; Cerebellar Neoplas | 2015 |
Gossypol sensitizes the antitumor activity of 5-FU through down-regulation of thymidylate synthase in human colon carcinoma cells.
Topics: Antineoplastic Combined Chemotherapy Protocols; Cell Proliferation; Colonic Neoplasms; Down-Regulati | 2015 |
Gossypol induces death receptor-5 through activation of the ROS-ERK-CHOP pathway and sensitizes colon cancer cells to TRAIL.
Topics: Apoptosis; Apoptosis Regulatory Proteins; Blotting, Western; Cell Line, Tumor; Cell Survival; Coloni | 2010 |
Molecular mechanism of gossypol-induced cell growth inhibition and cell death of HT-29 human colon carcinoma cells.
Topics: Apoptosis; Apoptosis Regulatory Proteins; bcl-X Protein; Caspases; Cell Cycle; Cell Death; Colonic N | 2003 |
Differential cytotoxic effect of gossypol on human melanoma, colon carcinoma, and other tissue culture cell lines.
Topics: Breast Neoplasms; Cell Division; Cell Line; Colonic Neoplasms; Fibroblasts; Gossypol; Humans; Leukem | 1984 |
Cytotoxic effect of gossypol on colon carcinoma cells.
Topics: Cell Cycle; Cell Death; Cell Survival; Clone Cells; Colonic Neoplasms; Contraceptive Agents, Male; D | 2000 |